Charles M. Rice | |
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Born | Charles Moen Rice August 25, 1952 Sacramento, California, U.S. |
Alma mater | University of California, Davis (BS) California Institute of Technology (MS, PhD) |
Awards | |
Scientific career | |
Institutions | |
Thesis | Studies on the Structural Proteins of Sindbis Virus (1981) |
Doctoral advisor | James Strauss |
Website | www |
Charles Moen Rice (born August 25, 1952) is an American virologist and Nobel Prize laureate whose main area of research is the hepatitis C virus. He is a professor of virology at the Rockefeller University in New York City and an adjunct professor at Cornell University and Washington University School of Medicine. At the time of the award he was a faculty at Rockefeller.
Rice is a Fellow of the American Association for the Advancement of Science, member of the National Academy of Sciences and was president of the American Society for Virology from 2002 to 2003. He received the 2016 Lasker-DeBakey Clinical Medical Research Award, jointly with Ralf F. W. Bartenschlager and Michael J. Sofia. [1] [2] Along with Michael Houghton and Harvey J. Alter, he was awarded the 2020 Nobel Prize in Physiology or Medicine "for the discovery of Hepatitis C virus." [3] [4]
Charles Moen Rice was born on August 25, 1952, in Sacramento, California. [5] [6]
Rice graduated Phi Beta Kappa [7] with a BS in zoology from University of California, Davis, in 1974. In 1981, he received his PhD in biochemistry from the California Institute of Technology, where he studied RNA viruses in the laboratory of James Strauss. [8] He remained at Caltech for four years to do postdoctoral research. [9] [10]
After his postdoctoral work, Rice moved with his research group to the Washington University School of Medicine in 1986, where he remained until 2001. [3]
Rice has been the Maurice R. and Corinne P. Greenberg Professor at Rockefeller University since 2001. He is also an adjunct professor at Washington University School of Medicine and Cornell University. He has served on committees for the Food and Drug Administration, National Institutes of Health, and World Health Organization. [9]
He was the editor of Journal of Experimental Medicine from 2003 to 2007, Journal of Virology from 2003 to 2008, and PLoS Pathogens from 2005 to present. He has been an author of over 400 peer-reviewed publications. [9]
While at Caltech, he was involved in researching the genome of Sindbis virus and the establishment of flaviviruses as their own family of viruses. The strain of yellow fever virus he used for this work was eventually used for the development of the yellow fever vaccine. While exploring Sindbis virus at Washington University in St. Louis, Rice described how he produced infectious flavivirus RNA in the laboratory in a 1989 paper published in The New Biologist. The paper attracted the attention of Stephen Feinstone who was studying hepatitis C virus and suggested that Rice use the technique to develop a vaccine for hepatitis C. In 1997, Rice cultured the first infectious clone of hepatitis C virus for use in studies on chimpanzees in whom the virus was also endemic. In 2005, Rice was also part of a team that showed that a strain of an acute form of the virus identified in a human patient can be forced to replicate in a laboratory setting. Rice's contribution to hepatitis C research has earned him many awards. [6]
David Baltimore is an American biologist, university administrator, and 1975 Nobel laureate in Physiology or Medicine. He is a professor of biology at the California Institute of Technology (Caltech), where he served as president from 1997 to 2006. He founded the Whitehead Institute and directed it from 1982 to 1990. In 2008, he served as president of the American Association for the Advancement of Science in 2008.
The Rockefeller University is a private biomedical research and graduate-only university in New York City, New York. It focuses primarily on the biological and medical sciences and provides doctoral and postdoctoral education. It is classified among "R2: Doctoral Universities – High research activity." Rockefeller is the oldest biomedical research institute in the United States.
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Harvey James Alter is an American medical researcher, virologist, physician and Nobel Prize laureate, who is best known for his work that led to the discovery of the hepatitis C virus. Alter is the former chief of the infectious disease section and the associate director for research of the Department of Transfusion Medicine at the Warren Grant Magnuson Clinical Center in the National Institutes of Health (NIH) in Bethesda, Maryland. In the mid-1970s, Alter and his research team demonstrated that most post-transfusion hepatitis cases were not due to hepatitis A or hepatitis B viruses. Working independently, Alter and Edward Tabor, a scientist at the U.S. Food and Drug Administration, proved through transmission studies in chimpanzees that a new form of hepatitis, initially called "non-A, non-B hepatitis" caused the infections, and that the causative agent was probably a virus. This work eventually led to the discovery of the hepatitis C virus in 1988, for which he shared the Nobel Prize in Physiology or Medicine in 2020 along with Michael Houghton and Charles M. Rice.
Francis Peyton Rous was an American pathologist at the Rockefeller University known for his works in oncoviruses, blood transfusion and physiology of digestion. A medical graduate from the Johns Hopkins University, he was discouraged to become a practicing physician due to severe tuberculosis. After three years of working as an instructor of pathology at the University of Michigan, he became dedicated researcher at the Rockefeller Institute for Medical Research for the rest of his career.
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Sir Michael Houghton is a British scientist and Nobel Prize laureate. Along with Qui-Lim Choo, George Kuo and Daniel W. Bradley, he co-discovered Hepatitis C in 1989. He also co-discovered the Hepatitis D genome in 1986. The discovery of the Hepatitis C virus (HCV) led to the rapid development of diagnostic reagents to detect HCV in blood supplies, which has reduced the risk of acquiring HCV through blood transfusion from one in three to about one in two million. It is estimated that antibody testing has prevented at least 40,000 new infections per year in the US alone and many more worldwide.
Ralf F. W. Bartenschlager is a German virologist who has been researching hepatitis C since 1989. He is a professor in the Department of Infectious Diseases at the Heidelberg University.
Michael J. Sofia is a chemist whose main research focus is hepatitis C virus and hepatitis B virus drug discovery. He was a co-recipient of the Lasker-DeBakey Clinical Medical Research Award for his work on hepatitis C in 2016 and of the Gertrude B. Elion Memorial Award from the International Society for Antiviral Research in 2017.
The 2020 Nobel Prize in Physiology or Medicine was awarded to the American virologists Harvey J. Alter, Michael Houghton and Charles M. Rice "for the discovery of Hepatitis C virus." During the award ceremony on December 10, 2020, Prof. Gunilla Karlsson-Hedestam said:
"The discovery of the Hepatitis C virus by this year’s Laureates laid the foundation for our current understanding about how the virus survives in its niche during the long chronic phase of the infection, and how liver disease develops. And importantly, it led to the development of highly effective anti-viral medicines that now cure the infection in almost all treated persons."