Dimitri Kullmann | |
---|---|
Born | Dimitri Michael Kullmann 1958 (age 65–66) [1] London, England [1] |
Education | Lycée Français Charles de Gaulle [1] |
Alma mater | University of Oxford (BM BCh, DPhil) |
Awards | Baly Medal (2017) [2] |
Scientific career | |
Fields | |
Institutions | |
Thesis | Central actions of muscle receptors (1984) |
Doctoral advisor | Julian Jack [4] |
Website | www |
Dimitri Michael Kullmann (born 1958) [1] FRS FMedSci MAE is a professor of neurology at the UCL Institute of Neurology, [2] University College London (UCL), and leads the synaptopathies initiative funded by the Wellcome Trust. [5] Kullmann is a member of the Queen Square Institute of Neurology Department of Clinical and Experimental Epilepsy [6] and a consultant neurologist at the National Hospital for Neurology and Neurosurgery. [3] [7]
Kullmann was educated at the Lycée Français Charles de Gaulle [1] and studied physiology at Balliol College, Oxford [1] where he was awarded a Bachelor of Arts (BA) degree and a Doctor of Philosophy degree. [4] He studied and trained at the University of Oxford and St Thomas's Hospital Medical School at the University of London. [2] His postgraduate research was supervised by Julian Jack. [4]
Kullmann's research [3] [7] investigates how synapses function in health and disease. [8] His laboratory helped to show how neurotransmitters activate different receptor subtypes in and around synapses, and resolved some controversies about the mechanisms of long-term changes in synaptic strength. [8] Genetic and autoimmune disorders of synaptic proteins (‘synaptopathies’) provide insights into the mechanisms of a broad range of neurological diseases including epilepsy and migraine. [8] Together with his colleagues, Kullmann has used these insights to devise gene therapy strategies that could be used to treat intractable epilepsy. [8] [3]
The Kullmann lab [3] [7] has contributed to the discovery and elucidation of silent synapses, [9] glutamate spillover, tonic inhibition, [10] long-term potentiation in interneurons, [11] neurological channelopathies [12] and Synaptopathies, gene therapy for epilepsy, [13] and mechanisms of neural oscillations. [14] Kullmann served as the editor-in-chief of the scientific journal Brain between 2014 and 2020 [15] and is on the editorial board of the journal Neuron . [16] Before working at UCL, he did postdoctoral research with Roger Nicoll at the University of California, San Francisco. [2]
Kullmann was awarded the University Gold Medal in Medicine by the University of London, in 1986. [2] and the Baly Medal by the Royal College of Physicians in 2017. [2] He was elected a Guarantor of Brain in 2000, [17] elected a Fellow of the Academy of Medical Sciences (FMedSci) in 2001, [18] a Corresponding Fellow of the American Neurological Association in 2013, [19] a member of the Academia Europaea (MAE) in 2017 [20] and a Fellow of the Royal Society (FRS) in 2018. [8]
Angela Vincent is Emeritus professor at the University of Oxford and a Fellow of Somerville College, Oxford.
In neuroscience, long-term potentiation (LTP) is a persistent strengthening of synapses based on recent patterns of activity. These are patterns of synaptic activity that produce a long-lasting increase in signal transmission between two neurons. The opposite of LTP is long-term depression, which produces a long-lasting decrease in synaptic strength.
Sir John Anthony Hardy is a human geneticist and molecular biologist at the Reta Lila Weston Institute of Neurological Studies at University College London with research interests in neurological diseases.
James Julian Bennett Jack is a New Zealand physiologist.
The UCL Queen Square Institute of Neurology is an institute within the Faculty of Brain Sciences of University College London (UCL) and is located in London, United Kingdom. Together with the National Hospital for Neurology and Neurosurgery, an adjacent facility with which it cooperates closely, the institute forms a major centre for teaching, training and research in neurology and allied clinical and basic neurosciences.
Christine Elizabeth Holt FRS, FMedSci is a British developmental neuroscientist.
Jonathan Felix Ashmore is a British physicist and Bernard Katz Professor of Biophysics at University College London.
Timothy Vivian Pelham Bliss FRS is a British neuroscientist. He is an adjunct professor at the University of Toronto, and a group leader emeritus at the Francis Crick Institute, London.
Stuart Graham Cull-Candy is a British neuroscientist. He holds the Gaddum Chair of Pharmacology and a personal Chair in Neuroscience at University College London. He is also a member of the Faculty of 1000 and held a Royal Society - Wolfson Research position.
A synaptopathy is a disease of the brain, spinal cord or peripheral nervous system relating to the dysfunction of synapses. This can arise as a result of a mutation in a gene encoding a synaptic protein such as an ion channel, neurotransmitter receptor, or a protein involved in neurotransmitter release. It can also arise as a result of an autoantibody targeting a synaptic protein. Synaptopathies caused by ion channel mutations are also known as synaptic channelopathies. An example is episodic ataxia. Myasthenia gravis is an example of an autoimmune synaptopathy. Some toxins also affect synaptic function. Tetanus toxin and botulinum toxin affect neurotransmitter release. Tetanus toxin can enter the body via a wound, and botulinum toxin can be ingested or administered therapeutically to alleviate dystonia or as cosmetic treatment.
John O'Keefe, is an American-British neuroscientist, psychologist and a professor at the Sainsbury Wellcome Centre for Neural Circuits and Behaviour and the Research Department of Cell and Developmental Biology at University College London. He discovered place cells in the hippocampus, and that they show a specific kind of temporal coding in the form of theta phase precession. He shared the Nobel Prize in Physiology or Medicine in 2014, together with May-Britt Moser and Edvard Moser; he has received several other awards. He has worked at University College London for his entire career, but also held a part-time chair at the Norwegian University of Science and Technology at the behest of his Norwegian collaborators, the Mosers.
Michael A. Häusser FRS FMedSci is professor of Neuroscience, based in the Wolfson Institute for Biomedical Research at University College London (UCL).
Annette Catherine Dolphin is a Professor of Pharmacology in the Department of Neuroscience, Physiology and Pharmacology at University College London (UCL).
Michael G Hanna is Director of the UCL Institute of Neurology, University College London and professor in clinical neurology and consultant neurologist at the National Hospital for Neurology and Neurosurgery, Queen Square, London, and also Director of the Medical Research Council (MRC) Centre for Neuromuscular Disease.
Maria Fitzgerald is a professor in the Department of Neuroscience at University College London.
David Lodge is a research fellow in the Department of Physiology and Pharmacology at the University of Bristol.
Robin Angus Silver is Professor of Neuroscience and a Wellcome Trust Principal Research Fellow at University College London. His laboratory studies neurotransmission and artificial neural networks by combining in vitro and in vivo experimental approaches with quantitative analysis and computational models developed in silico.
Neil Burgess is a British neuroscientist. He has been a professor of cognitive neuroscience at University College London since 2004 and a Wellcome Trust Principal Research Fellow since 2011. He has made important contributions to understanding memory and spatial cognition by developing computational models relating behaviour to activity in biological neural networks.
Tom Otis is an American researcher, academic and author. He is the Chief Scientific Officer at the Sainsbury Wellcome Centre for Neural Circuits and Behaviour and holds a Professorship in Neuroscience at University College London.
Stephanie Schorge is a Professor of Neuroscience in the Department of Neuroscience, Physiology and Pharmacology at University College London. She is known for her research into mutations that cause neurological diseases.
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