GRINL1A

POLR2M
Identifiers
Aliases	POLR2M , GCOM1, GRINL1A, Gdown, Gdown1, polymerase (RNA) II subunit M, RNA polymerase II subunit M
External IDs	OMIM: 606485 MGI: 107282 HomoloGene: 9181 GeneCards: POLR2M
Gene location (Human) Chr. Chromosome 15 (human) [1] Band 15q21.3 Start 57,706,695 bp [1] End 57,782,762 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9 D|9 39.85 cM Start 71,385,719 bp [2] End 71,393,217 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium Achilles tendon secondary oocyte vena cava optic nerve biceps brachii endometrium seminal vesicula vastus lateralis muscle parietal pleura Top expressed in somite hand maxillary prominence foot abdominal wall primitive streak atrium dorsomedial hypothalamic nucleus entorhinal cortex superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-directed 5'-3' RNA polymerase activity protein binding Cellular component RNA polymerase II, holoenzyme neuronal cell body nuclear envelope nucleus cytoplasm cell junction plasma membrane Z disc cytoskeleton membrane I band cortical actin cytoskeleton extrinsic component of cytoplasmic side of plasma membrane intracellular anatomical structure Biological process maintenance of ER location RNA biosynthetic process intracellular signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 81488 28015 Ensembl ENSG00000255529 ENSMUSG00000032199 UniProt P0CAP2 Q6EEV4 P0CAP1 Q6P6I6 RefSeq (mRNA) NM_001018102 NM_015532 NM_001164793 NM_178602 RefSeq (protein) NP_001018112 NP_056347 NP_001018112.1 NP_056347.1 NP_001018110 NP_689664 NP_001158265 NP_848717 Location (UCSC) Chr 15: 57.71 – 57.78 Mb Chr 9: 71.39 – 71.39 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

GRINL1A complex locus protein 1 is a protein that in humans is encoded by the GRINL1A gene. ^[5]

This gene (GRINL1A) is part of a complex transcript unit that includes the gene for GRINL1A combined protein (Gcom1). Transcription of this gene occurs at a downstream promoter, with at least three different alternatively spliced variants, grouped together as Gdown for GRINL1A downstream transcripts. The Gcom1 gene uses an upstream promoter for transcription and also has multiple alternatively spliced variants. ^[5]

See also

• NMDA receptor

References

1. GRCh38: Ensembl release 89: ENSG00000255529 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032199 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: GRINL1A glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Roginski RS, Mohan Raj BK, Finkernagel SW, Sciorra LJ (2001). "Assignment of an ionotropic glutamate receptor-like gene (GRINL1A) to human chromosome 15q22.1 by in situ hybridization". Cytogenet. Cell Genet. 93 (1–2): 143–4. doi:10.1159/000056971. PMID   11474202. S2CID   45209253.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Roginski RS, Mohan Raj BK, Birditt B, Rowen L (2005). "The human GRINL1A gene defines a complex transcription unit, an unusual form of gene organization in eukaryotes". Genomics. 84 (2): 265–76. doi:10.1016/j.ygeno.2004.04.004. PMID   15233991.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.

External links

• GRINL1A+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)