MAP1A

Last updated
MAP1A
Identifiers
Aliases MAP1A , MAP1L, MTAP1A, microtubule associated protein 1A
External IDs OMIM: 600178; MGI: 1306776; HomoloGene: 1778; GeneCards: MAP1A; OMA:MAP1A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002373

NM_001173506
NM_032393

RefSeq (protein)

NP_002364

NP_001166977
NP_115769

Location (UCSC)n/a Chr 2: 121.12 – 121.14 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Microtubule-associated protein 1A is a protein that in humans is encoded by the MAP1A gene. [4] [5] [6]

Contents

Function

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1A heavy chain and LC2 light chain. Expression of this gene is almost exclusively in the brain. Studies of the rat microtubule-associated protein 1A gene suggested a role in early events of spinal cord development. [6]

Interactions

MAP1A has been shown to interact with DISC1. [7]

Related Research Articles

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References

  1. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027254 Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Lien LL, Feener CA, Fischbach N, Kunkel LM (July 1994). "Cloning of human microtubule-associated protein 1B and the identification of a related gene on chromosome 15". Genomics. 22 (2): 273–80. doi:10.1006/geno.1994.1384. PMID   7806212.
  5. Fukuyama R, Rapoport SI (Sep 1995). "Brain-specific expression of human microtubule-associated protein 1A (MAP1A) gene and its assignment to human chromosome 15". J. Neurosci. Res. 40 (6): 820–5. doi:10.1002/jnr.490400613. PMID   7629894. S2CID   26831309.
  6. 1 2 "Entrez Gene: MAP1A microtubule-associated protein 1A".
  7. Morris JA, Kandpal G, Ma L, Austin CP (Jul 2003). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Hum. Mol. Genet. 12 (13): 1591–608. doi:10.1093/hmg/ddg162. PMID   12812986.

Further reading