NAPG

NAPG
Identifiers
Aliases	NAPG , GAMMASNAP, NSF attachment protein gamma
External IDs	OMIM: 603216 MGI: 104561 HomoloGene: 2838 GeneCards: NAPG
Gene location (Human)
Chr.	Chromosome 18 (human)
End	10,552,764 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	63,132,521 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; pons; ; Brodmann area 23; ; islet of Langerhans; ; middle temporal gyrus; ; dorsolateral prefrontal cortex; ; Brodmann area 9; ; prefrontal cortex; ; Achilles tendon; ; superior vestibular nucleus;
	Top expressed in
	subiculum; ; pontine nuclei; ; piriform cortex; ; medial dorsal nucleus; ; primary motor cortex; ; inferior colliculus; ; Region I of hippocampus proper; ; habenula; ; medial geniculate nucleus; ; medial vestibular nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	syntaxin binding ; protein binding ; soluble NSF attachment protein activity ;
Cellular component	myelin sheath ; lysosomal membrane ; SNARE complex ; extracellular exosome ; membrane ; mitochondrion ; vacuolar membrane ; synapse ;
Biological process	protein transport ; protein stabilization ; membrane fusion ; intracellular protein transport ; intra-Golgi vesicle-mediated transport ; vesicle-mediated transport ; transport ; protein-containing complex assembly ;
	Sources:Amigo / QuickGO
Orthologs
	8774
	108123
	ENSG00000134265
	ENSMUSG00000024581
	Q99747
	Q9CWZ7
	NM_003826
	NM_028017
	NP_003817
	NP_082293
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Gamma-soluble NSF attachment protein is a SNAP protein that in humans is encoded by the NAPG gene.^[5]^[6]

Function

NSF and SNAPs (NSF attachment proteins) are general elements of the cellular membrane transport apparatus. The sequence of the predicted 312-amino acid human protein encoded by NAPG is 95% identical to that of bovine gamma-SNAP. NAPG mediates platelet exocytosis and controls the membrane fusion events of this process.^[6]

Related Research Articles

N-ethylmaleimide-sensitive factor, also known as NSF or N-ethylmaleimide sensitive fusion proteins, is an enzyme which in humans is encoded by the NSF gene.

Synaptosomal-Associated Protein, 25kDa (SNAP-25) is a Target Soluble NSF (N-ethylmaleimide-sensitive factor) Attachment Protein Receptor (t-SNARE) protein encoded by the SNAP25 gene found on chromosome 20p12.2 in humans. SNAP-25 is a component of the trans-SNARE complex, which accounts for membrane fusion specificity and directly executes fusion by forming a tight complex that brings the synaptic vesicle and plasma membranes together.

Syntaxin-1A is a protein that in humans is encoded by the STX1A gene.

Syntaxin-4 is a protein that in humans is encoded by the STX4 gene.

Vesicle-associated membrane protein 2 (VAMP2) is a protein that in humans is encoded by the VAMP2 gene.

Golgi-associated PDZ and coiled-coil motif-containing protein is a protein that in humans is encoded by the GOPC gene.

Synaptobrevin-like protein 1 (SYBL1), also known as vesicle-associated membrane protein 7 (VAMP7), is a protein that in humans is encoded by the VAMP7, or SYBL1, gene.

Syntaxin-6 is a protein that in humans is encoded by the STX6 gene.

N-ethylmaleimide-sensitive factor Attachment Protein Alpha, also known as SNAP-α, is a SNAP protein that is involved in the intra-cellular trafficking and fusing of vesicles to target membranes in cells.

Vesicle-associated membrane protein 3 is a protein that in humans is encoded by the VAMP3 gene.

NSFL1 cofactor p47 is a protein that in humans is encoded by the NSFL1C gene.

Vesicle-associated membrane protein 8 is a protein that in humans is encoded by the VAMP8 gene.

Syntaxin-binding protein 2 is a protein that in humans is encoded by the STXBP2 gene.

Guanine nucleotide-binding protein G(T) subunit gamma-T1 is a protein that in humans is encoded by the GNGT1 gene.

DnaJ homolog subfamily C member 5, also known as cysteine string protein or CSP is a protein, that in humans encoded by the DNAJC5 gene. It was first described in 1990.

BET1-like protein is a protein that in humans is encoded by the BET1L gene.

Calcium-dependent secretion activator 1 is a protein that in humans is encoded by the CADPS gene.

BET1 homolog is a protein that in humans is encoded by the BET1 gene.

Beta-soluble NSF attachment protein is a SNAP protein involved in vesicular trafficking and exocytosis which is encoded by the NAPB gene humans is.

<span class="mw-page-title-main">Soluble NSF attachment protein</span> Protein family

Soluble N-ethylmaleimide-Sensitive Factor Attachment Proteins are a family of cytosolic adaptor proteins involved in vesicular fusion at membranes during intracellular transport and exocytosis. SNAPs interact with proteins of the SNARE complex and NSF to play a key role in recycling the components of the fusion complex. SNAPs are involved in the priming of the vesicle fusion complex during assembly, as well as in the disassembly following a vesicle fusion event. Following membrane fusion, the tethering SNARE proteins complex disassembles in response to steric changes originating from the ATPase NSF. The energy provided by NSF is transferred throughout the SNARE complex and SNAP, allowing the proteins to untangle, and recycled for future fusion events. Mammals have three SNAP genes: α-SNAP, β-SNAP, and γ-SNAP. α- and γ-SNAP are expressed throughout the body, while β-SNAP is specific to the brain. The yeast homolog of the human SNAP is Sec17, the structural diagram of which is included on this page.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000134265 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024581 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Lemons PP, Chen D, Bernstein AM, Bennett MK, Whiteheart SW (Sep 1997). "Regulated secretion in platelets: identification of elements of the platelet exocytosis machinery". Blood. 90 (4): 1490–500. doi: 10.1182/blood.V90.4.1490 . PMID 9269766.
1 2 "Entrez Gene: NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma".

Wilson DW, Whiteheart SW, Wiedmann M, et al. (1992). "A multisubunit particle implicated in membrane fusion". J. Cell Biol. 117 (3): 531–8. doi:10.1083/jcb.117.3.531. PMC 2289450 . PMID 1315316.
Whiteheart SW, Brunner M, Wilson DW, et al. (1992). "Soluble N-ethylmaleimide-sensitive fusion attachment proteins (SNAPs) bind to a multi-SNAP receptor complex in Golgi membranes". J. Biol. Chem. 267 (17): 12239–43. doi: 10.1016/S0021-9258(19)49830-X . PMID 1601890.
Whiteheart SW, Griff IC, Brunner M, et al. (1993). "SNAP family of NSF attachment proteins includes a brain-specific isoform". Nature. 362 (6418): 353–5. Bibcode:1993Natur.362..353W. doi:10.1038/362353a0. PMID 8455721. S2CID 4341471.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146 . PMID 9110174.
Mastick CC, Falick AL (1997). "Association of N-ethylmaleimide sensitive fusion (NSF) protein and soluble NSF attachment proteins-alpha and -gamma with glucose transporter-4-containing vesicles in primary rat adipocytes". Endocrinology. 138 (6): 2391–7. doi: 10.1210/endo.138.6.5166 . PMID 9165027.
Subramaniam VN, Loh E, Horstmann H, et al. (2000). "Preferential association of syntaxin 8 with the early endosome" (PDF). J. Cell Sci. 113 (6): 997–1008. doi:10.1242/jcs.113.6.997. PMID 10683148.
Chen D, Xu W, He P, et al. (2001). "Gaf-1, a gamma -SNAP-binding protein associated with the mitochondria". J. Biol. Chem. 276 (16): 13127–35. doi: 10.1074/jbc.M009424200 . PMID 11278501.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Tani K, Shibata M, Kawase K, et al. (2003). "Mapping of functional domains of gamma-SNAP". J. Biol. Chem. 278 (15): 13531–8. doi: 10.1074/jbc.M213205200 . PMID 12554740.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000134265 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024581 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9269766-5] Lemons PP, Chen D, Bernstein AM, Bennett MK, Whiteheart SW (Sep 1997). "Regulated secretion in platelets: identification of elements of the platelet exocytosis machinery". Blood. 90 (4): 1490–500. doi: 10.1182/blood.V90.4.1490 . PMID 9269766.

[entrez-6] 1 2 "Entrez Gene: NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma".

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NAPG

Contents

Function

Related Research Articles

References

Further reading