Nucleoporin 160

NUP160
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5A9Q
Identifiers
Aliases	NUP160 , nucleoporin 160, Nup160, 160kDa, 2810011M03Rik, AA414952, AU020188, Gtl-13, Gtl1-13, Gtl13, mKIAA0197, NPHS19
External IDs	OMIM: 607614 MGI: 1926227 HomoloGene: 32509 GeneCards: NUP160
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p11.2 Start 47,778,087 bp [1] End 47,848,555 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 E1 Start 90,507,559 bp [2] End 90,566,672 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte ganglionic eminence germinal epithelium endometrium Achilles tendon right uterine tube left lobe of thyroid gland gastric mucosa body of pancreas Top expressed in spermatid secondary oocyte maxillary prominence abdominal wall primitive streak dermis cumulus cell medial ganglionic eminence somite Paneth cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding structural constituent of nuclear pore Cellular component cytosol nuclear envelope nuclear pore nuclear pore outer ring nucleus kinetochore host cell Biological process mRNA transport protein transport viral process mRNA export from nucleus regulation of glycolytic process tRNA export from nucleus protein sumoylation viral transcription regulation of gene silencing by miRNA nephron development intracellular transport of virus regulation of cellular response to heat Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23279 59015 Ensembl ENSG00000030066 ENSMUSG00000051329 UniProt Q12769 Q9Z0W3 RefSeq (mRNA) NM_015231 NM_001318399 NM_021512 RefSeq (protein) NP_001305328 NP_056046 NP_067487 Location (UCSC) Chr 11: 47.78 – 47.85 Mb Chr 2: 90.51 – 90.57 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Nucleoporin 160 (Nup160) is a protein that in humans is encoded by the NUP160 gene. ^{[5] [6]}

NUP160 is 1 of up to 60 proteins that make up the 120-MD nuclear pore complex, which mediates nucleoplasmic transport.[supplied by OMIM] ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000030066 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000051329 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Vasu S, Shah S, Orjalo A, Park M, Fischer WH, Forbes DJ (Oct 2001). "Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export". J Cell Biol. 155 (3): 339–54. doi:10.1083/jcb.200108007. PMC   2150853 . PMID   11684705.
6. "Entrez Gene: NUP160 nucleoporin 160kDa".

Further reading

• Nagase T, Seki N, Ishikawa K, et al. (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi: 10.1093/dnares/3.1.17 . PMID   8724849.
• Belgareh N, Rabut G, Baï SW, et al. (2001). "An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells". J. Cell Biol. 154 (6): 1147–60. doi:10.1083/jcb.200101081. PMC   2150808 . PMID   11564755.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Loïodice I, Alves A, Rabut G, et al. (2005). "The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis". Mol. Biol. Cell. 15 (7): 3333–44. doi:10.1091/mbc.E03-12-0878. PMC   452587 . PMID   15146057.
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC   442147 . PMID   15231747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi: 10.1073/pnas.0507066103 . PMC   1459365 . PMID   16565220.
• Orjalo AV, Arnaoutov A, Shen Z, et al. (2006). "The Nup107-160 nucleoporin complex is required for correct bipolar spindle assembly". Mol. Biol. Cell. 17 (9): 3806–18. doi:10.1091/mbc.E05-11-1061. PMC   1593160 . PMID   16807356.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Glavy JS, Krutchinsky AN, Cristea IM, et al. (2007). "Cell-cycle-dependent phosphorylation of the nuclear pore Nup107-160 subcomplex". Proc. Natl. Acad. Sci. U.S.A. 104 (10): 3811–6. Bibcode:2007PNAS..104.3811G. doi: 10.1073/pnas.0700058104 . PMC   1820666 . PMID   17360435.
• Zuccolo M, Alves A, Galy V, et al. (2007). "The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions". EMBO J. 26 (7): 1853–64. doi:10.1038/sj.emboj.7601642. PMC   1847668 . PMID   17363900.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Nuclear pore complex protein Nup160