SYT13

SYT13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WFM
Identifiers
Aliases	SYT13 , synaptotagmin 13
External IDs	OMIM: 607716 MGI: 1933945 HomoloGene: 10823 GeneCards: SYT13
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p11.2 Start 45,240,302 bp [1] End 45,286,341 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 E1 Start 92,745,443 bp [2] End 92,786,403 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus Brodmann area 23 endothelial cell islet of Langerhans pons superior frontal gyrus postcentral gyrus entorhinal cortex prefrontal cortex dorsolateral prefrontal cortex Top expressed in islet of Langerhans medial dorsal nucleus habenula visual cortex dorsomedial hypothalamic nucleus medial geniculate nucleus ventral tegmental area piriform cortex superior frontal gyrus primary motor cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium-dependent phospholipid binding clathrin binding calcium ion binding syntaxin binding SNARE binding phosphatidylserine binding Cellular component integral component of membrane integral component of plasma membrane transport vesicle intracellular membrane-bounded organelle membrane plasma membrane presynapse synapse exocytic vesicle Biological process vesicle-mediated transport vesicle fusion regulation of calcium ion-dependent exocytosis calcium ion-regulated exocytosis of neurotransmitter regulation of dopamine secretion synaptic vesicle exocytosis calcium-ion regulated exocytosis cellular response to calcium ion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57586 80976 Ensembl ENSG00000019505 ENSMUSG00000027220 UniProt Q7L8C5 Q9EQT6 RefSeq (mRNA) NM_020826 NM_001247987 NM_030725 RefSeq (protein) NP_001234916 NP_065877 NP_109650 Location (UCSC) Chr 11: 45.24 – 45.29 Mb Chr 2: 92.75 – 92.79 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Synaptotagmin-13 is a protein that in humans is encoded by the SYT13 gene. ^{[5] [6]}

Function

SYT13 belongs to the large synaptotagmin protein family. All synaptotagmins show type I membrane topology, with an extracellular N terminus, a single transmembrane region, and a cytoplasmic C terminus containing tandem C2 domains. Major functions of synaptotagmins include vesicular traffic, exocytosis, and secretion.[supplied by OMIM] ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000019505 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027220 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Fukuda M, Mikoshiba K (March 2001). "Characterization of KIAA1427 protein as an atypical synaptotagmin (Syt XIII)". The Biochemical Journal. 354 (Pt 2): 249–57. doi:10.1042/0264-6021:3540249. PMC   1221650 . PMID   11171101.
6. "Entrez Gene: SYT13 synaptotagmin XIII".

Further reading

• Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (February 2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (1): 65–73. doi: 10.1093/dnares/7.1.65 . PMID   10718198.
• Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (September 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Craxton M (September 2001). "Genomic analysis of synaptotagmin genes". Genomics. 77 (1–2): 43–9. doi:10.1006/geno.2001.6619. PMID   11543631.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.

External links

• Overview of all the structural information available in the PDB for UniProt : Q7L8C5 (Human Synaptotagmin-13 (SYT13)) at the PDBe-KB .