Small nuclear ribonucleoprotein polypeptide C

SNRPC
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2VRD, 3CW1, 4PJO
Identifiers
Aliases	SNRPC , U1C, Yhc1, Small nuclear ribonucleoprotein polypeptide C
External IDs	OMIM: 603522 HomoloGene: 136764 GeneCards: SNRPC
Gene location (Human)
Chr.	Chromosome 6 (human)
End	34,773,857 bp
RNA expression pattern
	Top expressed in
	left ventricle; ; ganglionic eminence; ; gastrocnemius muscle; ; right uterine tube; ; body of stomach; ; left uterine tube; ; body of pancreas; ; lymph node; ; left coronary artery; ; right adrenal gland;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity ; zinc ion binding ; metal ion binding ; protein binding ; single-stranded RNA binding ; nucleic acid binding ; U1 snRNA binding ; pre-mRNA 5'-splice site binding ; U1 snRNP binding ; RNA binding ; mRNA binding ;
Cellular component	Cajal body ; prespliceosome ; U1 snRNP ; nucleus ; commitment complex ; nucleoplasm ; U2-type prespliceosome ;
Biological process	spliceosomal snRNP assembly ; mRNA 5'-splice site recognition ; mRNA splicing, via spliceosome ;
	Sources:Amigo / QuickGO
Orthologs
	6631
	n/a
	ENSG00000124562
	n/a
	P09234
	n/a
	NM_003093
	n/a
	NP_003084
	n/a
	Wikidata
View/Edit Human

Last updated December 12, 2023

U1 small nuclear ribonucleoprotein C is a protein that in humans is encoded by the SNRPC gene.^[3]^[4]^[5]

Interactions

Small nuclear ribonucleoprotein polypeptide C has been shown to interact with Ewing sarcoma breakpoint region 1.^[6]

Related Research Articles

Gideon Dreyfuss is an American biochemist, the Isaac Norris Professor of Biochemistry and Biophysics at the University of Pennsylvania School of Medicine, and an investigator of the Howard Hughes Medical Institute. He was elected to the National Academy of Sciences in 2012.

<span class="mw-page-title-main">U1 spliceosomal RNA</span>

U1 spliceosomal RNA is the small nuclear RNA (snRNA) component of U1 snRNP, an RNA-protein complex that combines with other snRNPs, unmodified pre-mRNA, and various other proteins to assemble a spliceosome, a large RNA-protein molecular complex upon which splicing of pre-mRNA occurs. Splicing, or the removal of introns, is a major aspect of post-transcriptional modification, and takes place only in the nucleus of eukaryotes.

<span class="mw-page-title-main">U4 spliceosomal RNA</span> Non-coding RNA component of the spliceosome

The U4 small nuclear Ribo-Nucleic Acid is a non-coding RNA component of the major or U2-dependent spliceosome – a eukaryotic molecular machine involved in the splicing of pre-messenger RNA (pre-mRNA). It forms a duplex with U6, and with each splicing round, it is displaced from the U6 snRNA in an ATP-dependent manner, allowing U6 to re-fold and create the active site for splicing catalysis. A recycling process involving protein Brr2 releases U4 from U6, while protein Prp24 re-anneals U4 and U6. The crystal structure of a 5′ stem-loop of U4 in complex with a binding protein has been solved.

<span class="mw-page-title-main">U7 small nuclear RNA</span>

The U7 small nuclear RNA is an RNA molecule and a component of the small nuclear ribonucleoprotein complex. The U7 snRNA is required for histone pre-mRNA processing.

Survival of motor neuron or survival motor neuron (SMN) is a protein that in humans is encoded by the SMN1 and SMN2 genes.

rRNA 2'-O-methyltransferase fibrillarin is an enzyme that in humans is encoded by the FBL gene.

snRNP70 also known as U1 small nuclear ribonucleoprotein 70 kDa is a protein that in humans is encoded by the SNRNP70 gene. snRNP70 is a small nuclear ribonucleoprotein that associates with U1 spliceosomal RNA, forming the U1snRNP a core component of the spliceosome. The U1-70K protein and other components of the spliceosome complex form detergent-insoluble aggregates in both sporadic and familial human cases of Alzheimer's disease. U1-70K co-localizes with Tau in neurofibrillary tangles in Alzheimer's disease.

Small nuclear ribonucleoprotein Sm D1 is a protein that in humans is encoded by the SNRPD1 gene.

Small nuclear ribonucleoprotein-associated proteins B and B' is a protein that in humans is encoded by the SNRPB gene.

Small nuclear ribonucleoprotein-associated protein N is a protein that in humans is encoded by the SNRPN gene.

Small nuclear ribonucleoprotein Sm D2 is a protein that in humans is encoded by the SNRPD2 gene. It belongs to the small nuclear ribonucleoprotein core protein family, and is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.

Small nuclear ribonucleoprotein E is a protein that in humans is encoded by the SNRPE gene.

Small nuclear ribonucleoprotein Sm D3 is a protein that in humans is encoded by the SNRPD3 gene.

U1 small nuclear ribonucleoprotein A is a protein that in humans is encoded by the SNRPA gene.

Small nuclear ribonucleoprotein F is a protein that in humans is encoded by the SNRPF gene.

U2 small nuclear ribonucleoprotein A' is a protein that in humans is encoded by the SNRPA1 gene.

U2 small nuclear ribonucleoprotein B is a protein that in humans is encoded by the SNRPB2 gene.

U4/U6 small nuclear ribonucleoprotein Prp4 is a protein that in humans is encoded by the PRPF4 gene. The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors. PRPF4 is 1 of several proteins that associate with U4 and U6 snRNPs.[supplied by OMIM]

Gem-associated protein 4 is a protein that in humans is encoded by the GEMIN4 gene.

Ribonuclease P protein subunit p38 is an enzyme that in humans is encoded by the RPP38 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000124562 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Sillekens PT, Beijer RP, Habets WJ, van Venrooij WJ (September 1988). "Human U1 snRNP-specific C protein: complete cDNA and protein sequence and identification of a multigene family in mammals". Nucleic Acids Research. 16 (17): 8307–21. doi:10.1093/nar/16.17.8307. PMC 338560 . PMID 2971157.
↑ Gunnewiek JM, van Aarssen Y, Wassenaar R, Legrain P, van Venrooij WJ, Nelissen RL (December 1995). "Homodimerization of the human U1 snRNP-specific protein C". Nucleic Acids Research. 23 (23): 4864–71. doi:10.1093/nar/23.23.4864. PMC 307476 . PMID 8532530.
↑ "Entrez Gene: SNRPC small nuclear ribonucleoprotein polypeptide C".
↑ Knoop LL, Baker SJ (August 2000). "The splicing factor U1C represses EWS/FLI-mediated transactivation". The Journal of Biological Chemistry. 275 (32): 24865–71. doi: 10.1074/jbc.M001661200 . PMID 10827180.

Yamamoto K, Miura H, Moroi Y, Yoshinoya S, Goto M, Nishioka K, Miyamoto T (January 1988). "Isolation and characterization of a complementary DNA expressing human U1 small nuclear ribonucleoprotein C polypeptide". Journal of Immunology. 140 (1): 311–7. doi: 10.4049/jimmunol.140.1.311 . PMID 2961811. S2CID 45846091.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Nelissen RL, Gunnewiek JM, Lambermon MH, Van Venrooij WJ (January 1997). "Cloning and characterization of two processed pseudogenes and the cDNA for the murine U1 snRNP-specific protein C". Gene. 184 (2): 273–8. doi:10.1016/S0378-1119(96)00612-9. hdl: 2066/27882 . PMID 9031639.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Dumortier H, Klein Gunnewiek J, Roussel JP, van Aarssen Y, Briand JP, van Venrooij WJ, Muller S (December 1998). "At least three linear regions but not the zinc-finger domain of U1C protein are exposed at the surface of the protein in solution and on the human spliceosomal U1 snRNP particle". Nucleic Acids Research. 26 (23): 5486–91. doi:10.1093/nar/26.23.5486. PMC 147990 . PMID 9826776.
Charroux B, Pellizzoni L, Perkinson RA, Yong J, Shevchenko A, Mann M, Dreyfuss G (March 2000). "Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli". The Journal of Cell Biology. 148 (6): 1177–86. doi:10.1083/jcb.148.6.1177. PMC 2174312 . PMID 10725331.
Knoop LL, Baker SJ (August 2000). "The splicing factor U1C represses EWS/FLI-mediated transactivation". The Journal of Biological Chemistry. 275 (32): 24865–71. doi: 10.1074/jbc.M001661200 . PMID 10827180.
Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G (March 2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component". The Journal of Biological Chemistry. 277 (9): 7540–5. doi: 10.1074/jbc.M110141200 . PMID 11748230.
Förch P, Puig O, Martínez C, Séraphin B, Valcárcel J (December 2002). "The splicing regulator TIA-1 interacts with U1-C to promote U1 snRNP recruitment to 5' splice sites". The EMBO Journal. 21 (24): 6882–92. doi:10.1093/emboj/cdf668. PMC 139089 . PMID 12486009.
Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (January 2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (January 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000124562 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2971157-3] Sillekens PT, Beijer RP, Habets WJ, van Venrooij WJ (September 1988). "Human U1 snRNP-specific C protein: complete cDNA and protein sequence and identification of a multigene family in mammals". Nucleic Acids Research. 16 (17): 8307–21. doi:10.1093/nar/16.17.8307. PMC 338560 . PMID 2971157.

[pmid8532530-4] Gunnewiek JM, van Aarssen Y, Wassenaar R, Legrain P, van Venrooij WJ, Nelissen RL (December 1995). "Homodimerization of the human U1 snRNP-specific protein C". Nucleic Acids Research. 23 (23): 4864–71. doi:10.1093/nar/23.23.4864. PMC 307476 . PMID 8532530.

[entrez-5] "Entrez Gene: SNRPC small nuclear ribonucleoprotein polypeptide C".

[pmid10827180-6] Knoop LL, Baker SJ (August 2000). "The splicing factor U1C represses EWS/FLI-mediated transactivation". The Journal of Biological Chemistry. 275 (32): 24865–71. doi: 10.1074/jbc.M001661200 . PMID 10827180.

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[6]

v t e RNA-binding protein: Ribonucleoproteins
snRNP	A A1 B B2 C D1 D2 D3 E F G N 70K/U1 spliceosomal RNA SNRNP200
hnRNP	A0 C L R
Other transcription	Telomerase
Translation	Ribosome
Vault ribonucleoprotein particles	Major vault protein
Other	Signal recognition particle

Small nuclear ribonucleoprotein polypeptide C

Contents

Interactions

Related Research Articles

References

Further reading