Small nuclear ribonucleoprotein polypeptide E

Last updated
SNRPE
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases SNRPE , B-raf, HYPT11, SME, Sm-E, Small nuclear ribonucleoprotein polypeptide E, snRNP-E
External IDs OMIM: 128260 MGI: 3650419 HomoloGene: 136765 GeneCards: SNRPE
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001304464
NM_003094
NM_001328637
NM_001328638

n/a

RefSeq (protein)

NP_001291393
NP_001315566
NP_001315567
NP_003085

n/a

Location (UCSC) Chr 1: 203.86 – 203.87 Mb n/a
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Small nuclear ribonucleoprotein E is a protein that in humans is encoded by the SNRPE gene. [4] [5] [6]

Contents

Interactions

Small nuclear ribonucleoprotein polypeptide E has been shown to interact with DDX20 [7] and Small nuclear ribonucleoprotein polypeptide F. [8]

Related Research Articles

snRNPs, or small nuclear ribonucleoproteins, are RNA-protein complexes that combine with unmodified pre-mRNA and various other proteins to form a spliceosome, a large RNA-protein molecular complex upon which splicing of pre-mRNA occurs. The action of snRNPs is essential to the removal of introns from pre-mRNA, a critical aspect of post-transcriptional modification of RNA, occurring only in the nucleus of eukaryotic cells. Additionally, U7 snRNP is not involved in splicing at all, as U7 snRNP is responsible for processing the 3′ stem-loop of histone pre-mRNA.

Gideon Dreyfuss is an American biochemist who is the Isaac Norris Professor of Biochemistry and Biophysics at the University of Pennsylvania School of Medicine and an investigator of the Howard Hughes Medical Institute. He was elected to the National Academy of Sciences in 2012.

LSm

In molecular biology, LSm proteins are a family of RNA-binding proteins found in virtually every cellular organism. LSm is a contraction of 'like Sm', because the first identified members of the LSm protein family were the Sm proteins. LSm proteins are defined by a characteristic three-dimensional structure and their assembly into rings of six or seven individual LSm protein molecules, and play a large number of various roles in mRNA processing and regulation.

Survival of motor neuron Protein in animal cells

Survival of motor neuron or survival motor neuron (SMN) is a protein that in humans is encoded by the SMN1 and SMN2 genes.

Fibrillarin

rRNA 2'-O-methyltransferase fibrillarin is an enzyme that in humans is encoded by the FBL gene.

Small nuclear ribonucleoprotein D1

Small nuclear ribonucleoprotein Sm D1 is a protein that in humans is encoded by the SNRPD1 gene.

SNRPB

Small nuclear ribonucleoprotein-associated proteins B and B' is a protein that in humans is encoded by the SNRPB gene.

Small nuclear ribonucleoprotein D2

Small nuclear ribonucleoprotein Sm D2 is a protein that in humans is encoded by the SNRPD2 gene. It belongs to the small nuclear ribonucleoprotein core protein family, and is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.

SNRPD3

Small nuclear ribonucleoprotein Sm D3 is a protein that in humans is encoded by the SNRPD3 gene.

Gem-associated protein 2

Gem-associated protein 2 (GEMIN2), also called survival of motor neuron protein-interacting protein 1 (SIP1), is a protein that in humans is encoded by the GEMIN2 gene.

DDX20 Protein-coding gene in the species Homo sapiens

Probable ATP-dependent RNA helicase DDX20, also known as DEAD-box helicase 20 and gem-associated protein 3 (GEMIN3), is an enzyme that in humans is encoded by the DDX20 gene.

Small nuclear ribonucleoprotein polypeptide F

Small nuclear ribonucleoprotein F is a protein that in humans is encoded by the SNRPF gene.

SNRPB2

U2 small nuclear ribonucleoprotein B is a protein that in humans is encoded by the SNRPB2 gene.

SNRPG

Small nuclear ribonucleoprotein G is a protein that in humans is encoded by the SNRPG gene.

Small nuclear ribonucleoprotein polypeptide C

U1 small nuclear ribonucleoprotein C is a protein that in humans is encoded by the SNRPC gene.

Gem-associated protein 7

Gem-associated protein 7 is a protein that in humans is encoded by the GEMIN7 gene. The gem-associated proteins are those found in the gems of Cajal bodies.

Gem-associated protein 6

Gem-associated protein 6 is a protein that in humans is encoded by the GEMIN6 gene. The gem-associated proteins are those found in the gems of Cajal bodies.

LSM2

U6 snRNA-associated Sm-like protein LSm2 is a protein that in humans is encoded by the LSM2 gene.

Gem-associated protein 4

Gem-associated protein 4 is a protein that in humans is encoded by the GEMIN4 gene.

Gem-associated protein 5

Gem-associated protein 5 is a protein that in humans is encoded by the GEMIN5 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000182004 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Fautsch MP, Wieben ED (December 1991). "Transcriptional regulation of the small nuclear ribonucleoprotein E protein gene. Identification of cis-acting sequences with homology to genes encoding ribosomal proteins". The Journal of Biological Chemistry. 266 (34): 23288–95. doi: 10.1016/S0021-9258(18)54495-1 . PMID   1835977.
  5. Neiswanger K, Stanford DR, Sparkes RS, Nishimura D, Mohandas T, Klisak I, Heinzmann C, Wieben ED (August 1990). "Assignment of the gene for the small nuclear ribonucleoprotein E (SNRPE) to human chromosome 1q25-q43". Genomics. 7 (4): 503–8. doi:10.1016/0888-7543(90)90192-W. PMID   2143747.
  6. "Entrez Gene: SNRPE small nuclear ribonucleoprotein polypeptide E".
  7. Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (December 1999). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". The Journal of Cell Biology. 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. PMC   2168095 . PMID   10601333.
  8. Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (November 1997). "Multiple protein: protein interactions between the snRNP common core proteins". Experimental Cell Research. 237 (1): 63–9. doi:10.1006/excr.1997.3750. PMID   9417867.

Further reading