Vlado Perkovic

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Vlado Perkovic
Alma mater University of Melbourne
Occupation(s)-Dean of the Faculty of Medicine and Scientia Professor at the University of New South Wales [1]
-Renal Physician
-Staff Specialist in Nephrology at the Royal North Shore Hospital
-George Clinical Board Member [2]
-George Clinical Scientific Leader [3]
Employer(s)-Royal Melbourne Hospital (2002-2005)
-Royal North Shore Hospital (2005-present)
-George Institute for Global Health (2007-present)
-George Clinical (2009–present)
-University of Sydney (2012-2017) [4]
-University of New South Wales (2017-present)

Vlado Perkovic (born March 8) is an Australian renal physician and researcher who is the Provost at the University of New South Wales, Sydney, having previously been Dean of Medicine & Health at that University between 2019 and 2023. [5]

Contents

He is also an Honorary Fellow at the George Institute for Global Health Australia [6] [ circular reference ], and a kidney disease researcher leading a number of international clinical trials.

Career

Perkovic moved to Sydney and into professional academia after completing his PhD in 2005. The thesis undertaken at the University of Melbourne was entitled “The Cardiovascular Aspects of Kidney Disease”. [7] Perkovic relocated to Sydney to take on a position as Associate Principal Director at The George Institute for Global Health (2007-2008), and was appointed Conjoint Senior Lecturer at the University of Sydney. Perkovic worked in a number of senior research and executive positions at The George Institute, before being appointed Executive Director of The George Institute, Australia in 2012. In 2017 Perkovic was appointed to lead the non-communicable diseases theme as part of the University of New South Wales Medicine's thematic research strategy. [1] In 2019, he was appointed as the Dean of Medicine at University of New South Wales. [1]

From 2009-2014 Perkovic was the executive director of George Clinical, [2] one of The George Institute's commercial enterprises. He was appointed to the board of George Clinical in 2010 and held this position until 2023.

Perkovic regularly appears in the media worldwide [8] [9] [10] as an authority in the fields of kidney disease, hypertension, cardiovascular disease, and clinical trials. His research is widely cited [11] and has been responsible for changing medical guidelines.

Perkovic is a fellow of the Royal Australasian College of Physicians (1999), the American Society of Nephrology, (2008) and the Australian Academy of Health and Medical Sciences (2016). Some of his previous positions include being President of the Association of Australian Medical Research Institutes (AAMRI, the peak body for Medical Research Institutes), Chairman of the International Society of Nephrology Advancing Clinical Trials initiative (ISN-ACT 2016-), a member of the Executive Committee and Board of Australian Clinical Trials Alliance, (2016-8), a member of the Executive Operations Secretariat, Australasian Kidney Trials Network (2016-) and Chair of the AKTN Scientific Committee 2013-6. He was previously a member of the Health Translation Advisory Committee (HTAC) of the National Health and Medical Research Council (2015-8)

Research focus and publications

Perkovic has published more than 400 peer-reviewed papers, [12] and his career has been based on clinical research investigating the prevention and treatment of kidney disease, and its complications. As well as epidemiological research identifying important risk factors, Perkovic has led a broad suite of clinical trials and meta-analyses aiming to identify effective interventions that slow the progression of kidney disease and reduce the risk of developing the many complications of kidney disease. Some of Perkovic's key outputs here have been work on diabetic nephropathy published in a range of journals, [12] and studies of blood pressure lowering, lipid lowering and a range of other interventions for the prevention of kidney failure and cardiovascular outcomes in people with kidney disease. Perkovic's ongoing work includes further systematic reviews, large scale global trials of steroids for the prevention of kidney failure in IgA nephropathy (Co-Principal Investigator), and Steering Committee roles in a number of global, pharma-funded trials studying treatments for the prevention of kidney failure in diabetic nephropathy. This includes a role as Chair of the CREDENCE trial Steering Committee, the first trial to convincingly demonstrate the benefits of the SGLT2 inhibitor canagliflozin on the risk of kidney failure and cardiovascular outcomes in people with diabetes and kidney disease. [13]

Perkovic's research has led to major publications in the New England Journal of Medicine, [14] Lancet, [15] [16] BMJ, [17] Annals of Internal Medicine, [18] PLoS Medicine [19] and a range of specialty journals. He was appointed to the Editorial Board of the New England Journal of Medicine in 2017, the first Australian to receive this honour.

Personal life

Perkovic was born in Brinje, Croatia and moved to Australia with his family before the age of one. He lived in Melbourne and trained in medicine at the University of Melbourne and the Royal Melbourne Hospital, receiving his MBBS and Doctor of Philosophy qualifications from The University of Melbourne in 1992 and 2005 respectively. He is married with three sons. Prior to pursuing a career in academia, he worked as a nephrologist and general physician at the Royal Melbourne Hospital, (2002-2005), and was Head of Haemodialysis for the North West Dialysis Service, Royal Melbourne Hospital. From 2005 when he moved to Sydney, until 2023, Perkovic held a part-time appointment as a specialist in nephrology and hypertension at the Royal North Shore Hospital, Sydney.

Related Research Articles

<span class="mw-page-title-main">Kidney disease</span> Damage to or disease of a kidney

Kidney disease, or renal disease, technically referred to as nephropathy, is damage to or disease of a kidney. Nephritis is an inflammatory kidney disease and has several types according to the location of the inflammation. Inflammation can be diagnosed by blood tests. Nephrosis is non-inflammatory kidney disease. Nephritis and nephrosis can give rise to nephritic syndrome and nephrotic syndrome respectively. Kidney disease usually causes a loss of kidney function to some degree and can result in kidney failure, the complete loss of kidney function. Kidney failure is known as the end-stage of kidney disease, where dialysis or a kidney transplant is the only treatment option.

<span class="mw-page-title-main">Enalapril</span> ACE inhibitor medication

Enalapril, sold under the brand name Vasotec among others, is an ACE inhibitor medication used to treat high blood pressure, diabetic kidney disease, and heart failure. For heart failure, it is generally used with a diuretic, such as furosemide. It is given by mouth or by injection into a vein. Onset of effects are typically within an hour when taken by mouth and last for up to a day.

<span class="mw-page-title-main">Chronic kidney disease</span> Medical condition

Chronic kidney disease (CKD) is a type of kidney disease in which a gradual loss of kidney function occurs over a period of months to years. Initially generally no symptoms are seen, but later symptoms may include leg swelling, feeling tired, vomiting, loss of appetite, and confusion. Complications can relate to hormonal dysfunction of the kidneys and include high blood pressure, bone disease, and anemia. Additionally CKD patients have markedly increased cardiovascular complications with increased risks of death and hospitalization.

<span class="mw-page-title-main">Diabetic nephropathy</span> Chronic loss of kidney function

Diabetic nephropathy, also known as diabetic kidney disease, is the chronic loss of kidney function occurring in those with diabetes mellitus. Diabetic nephropathy is the leading causes of chronic kidney disease (CKD) and end-stage renal disease (ESRD) globally. The triad of protein leaking into the urine, rising blood pressure with hypertension and then falling renal function is common to many forms of CKD. Protein loss in the urine due to damage of the glomeruli may become massive, and cause a low serum albumin with resulting generalized body swelling (edema) so called nephrotic syndrome. Likewise, the estimated glomerular filtration rate (eGFR) may progressively fall from a normal of over 90 ml/min/1.73m2 to less than 15, at which point the patient is said to have end-stage renal disease. It usually is slowly progressive over years.

<span class="mw-page-title-main">Hypertensive kidney disease</span> Medical condition

Hypertensive kidney disease is a medical condition referring to damage to the kidney due to chronic high blood pressure. It manifests as hypertensive nephrosclerosis. It should be distinguished from renovascular hypertension, which is a form of secondary hypertension, and thus has opposite direction of causation.

Microalbuminuria is a term to describe a moderate increase in the level of urine albumin. It occurs when the kidney leaks small amounts of albumin into the urine, in other words, when an abnormally high permeability for albumin in the glomerulus of the kidney occurs. Normally, the kidneys filter albumin, so if albumin is found in the urine, then it is a marker of kidney disease. The term microalbuminuria is now discouraged by Kidney Disease Improving Global Outcomes and has been replaced by moderately increased albuminuria.

The George Institute for Global Health, is an independent medical research institute headquartered in Australia with offices in China, India and the United Kingdom. The George Institute conducts research on non-communicable disease, including heart and kidney disease, stroke, diabetes, and injury. The institute is known for conducting large-scale clinical studies. Between 1999 and 2017, the George has consumed over A$750 million in research grant and fundraising.

<span class="mw-page-title-main">Perindopril</span> High blood pressure medication

Perindopril is a medication used to treat high blood pressure, heart failure, or stable coronary artery disease.

<span class="mw-page-title-main">Baker Heart and Diabetes Institute</span>

The Baker Heart and Diabetes Institute, commonly known as the Baker Institute, is an Australian independent medical research institute headquartered in Melbourne, Victoria. Established in 1926, the institute is one of Australia's oldest medical research organisations with a historical focus on cardiovascular disease. In 2008, it became the country's first medical research institute to target diabetes, heart disease, obesity and their complications at the basic, clinical and population health levels.

<span class="mw-page-title-main">Canagliflozin</span> Chemical compound

Canagliflozin, sold under the brand name Invokana among others, is a medication used to treat type 2 diabetes. It is used together with exercise and diet. It is not recommended in type 1 diabetes. It is taken by mouth.

Kamyar Kalantar-Zadeh is an Iranian-American physician doing research in nephrology, kidney dialysis, nutrition, and epidemiology. He is best known as a specialist in kidney disease nutrition and chronic kidney disease and for his hypothesis about the longevity of individuals with chronic disease states, also known as reverse epidemiology including obesity paradox. According to this hypothesis, obesity or hypercholesterolemia may counterintuitively be protective and associated with greater survival in certain groups of people, such as elderly individuals, dialysis patients, or those with chronic disease states and wasting syndrome (cachexia), whereas normal to low body mass index or normal values of serum cholesterol may be detrimental and associated with worse mortality. Kalantar-Zadeh is also known for his expertise in kidney dialysis therapy, including incremental dialysis, as well as renal nutrition. He is the brother of Kourosh Kalantar-zadeh, who is an Australian scientist involved in research in the fields of materials sciences, nanotechnology, and transducers.

Stephen William MacMahon AO DSc FAA FMediSci FAHMS FACC is a British-Australian academic medical researcher, healthcare entrepreneur and founder of The George Institute for Global Health. He holds professorial academic appointments in medicine at UNSW Sydney and Imperial College London.

Mesoamerican nephropathy (MeN) is an endemic, non-diabetic, non-hypertensive chronic kidney disease (CKD) characterized by reduced glomerular filtration rate (GFR) with mild or no proteinuria and no features of known primary glomerular diseases. MeN is prevalent in agricultural communities along the Pacific Ocean coastal lowlands Mesoamerica, including southern Mexico, Guatemala, El Salvador, Nicaragua, Honduras and Costa Rica. Although most cases have been described among agricultural workers, MeN has also been described in other occupations, including miners, brick manufacturers, and fishermen. A common denominator among these occupations is that they are outdoor workers who reside in rural areas in hot and humid climates.

Sharon A. Anderson is an American physician, educator, and researcher practicing in Portland, Oregon. She has contributed extensively to the study of the progression of chronic kidney disease. Her research has focused on diabetic nephropathy, polycystic kidney disease and the pathophysiology of the aging kidney. She was the first woman to serve as President of the American Society of Nephrology (ASN). She was the Chief of the Department of Medicine at the Veteran's Affairs Medical Center in Portland and is currently the Chair of the Department of Medicine at Oregon Health and Science University (OHSU). She has been appointed to the National Institutes of Health Council of Councils. Her publications as author or co-author number greater than 150.

Professor David Wayne Johnson is an Australian nephrologist known for kidney treatments and transplants in Australia. In 2009 he was a Queensland State Finalist for Australian of the Year, for his work in the early recognition and care of people with chronic kidney disease and specifically for his work in detection of chronic kidney disease.

<span class="mw-page-title-main">Martin Barratt</span> British paediatrician and professor

Thomas Martin Barratt was a British paediatrician and professor of paediatric nephrology. Barratt was most notable for developing a specialist service for children with kidney diseases in Britain, bringing peritoneal dialysis, haemodialysis, and later renal transplantation to ever younger children. Barratt was an early advocate for multidisciplinary care and developed a model that was later taken up by many other specialist centres across the world. His research led to a new treatments for many types of childhood kidney diseases., and for research into childhood Nephrotic syndrome and Hemolytic-uremic syndrome.

Professor Wendy Elizabeth Hoy AO is a Fellow of the Australian Academy of Science (FAA), the Director of the Centre for Chronic Disease at the University of Queensland, Australia, and was appointed an Officer of the Order of Australia (AO) in 2010 and elected as a member of the Australian Academy of Science in 2015. Hoy's research has involved developing new types of kidney imaging and improving health and lives for indigenous populations, in Australia, Sri Lanka and the USA.

<span class="mw-page-title-main">Andrew S. Levey</span> American nephrologist (born 1950)

Andrew S. Levey is an American nephrologist who transformed chronic kidney disease (CKD) clinical practice, research, and public health by developing equations to estimate glomerular filtration rate (GFR), and leading the global standardization of CKD definition and staging.

<span class="mw-page-title-main">Josef Coresh</span> American epidemiologist

Josef Coresh is an American epidemiologist. He is the inaugural George W. Comstock Professor in the Department of Epidemiology at Johns Hopkins University. Coresh serves as the director of both the Cardiovascular Epidemiology Training Program and the George W. Comstock Center for Public Health Research and Prevention at the Johns Hopkins School of Medicine.

<span class="mw-page-title-main">Roxana Mehran</span> Cardiologist

Roxana Mehran is an Iranian-American cardiologist and Mount Sinai Endowed Professor of Medicine at the Icahn School of Medicine at Mount Sinai. She is known for her work in interventional cardiology.

References

  1. 1 2 3 "UNSW Sydney". unsw.edu.au. Retrieved 4 April 2023.
  2. 1 2 "Board of Directors - George Clinical - Leading Asia Pacific CRO". Georgeclinical.com. Retrieved 8 October 2017.
  3. ↑ "Scientific Leaders - George Clinical - Leading Asia Pacific CRO". Georgeclinical.com. Retrieved 8 October 2017.
  4. ↑ Sydney, The University of. "Find a researcher - Sydney Medical School - The University of Sydney". sydney.edu.au. Retrieved 8 October 2017.
  5. ↑ "About us | Medicine & Health - UNSW Sydney".
  6. ↑ George Institute for Global Health
  7. ↑ Perkovic, Vlado; Ninomiya, Toshiharu; Arima, Hisatomi; Gallagher, Martin; Jardine, Meg; Cass, Alan; Neal, Bruce; MacMahon, Stephen; Chalmers, John (1 October 2007). "Chronic Kidney Disease, Cardiovascular Events, and the Effects of Perindopril-Based Blood Pressure Lowering: Data from the PROGRESS Study". Journal of the American Society of Nephrology. 18 (10): 2766–2772. doi: 10.1681/ASN.2007020256 . PMID   17804673 . Retrieved 8 October 2017– via jasn.asnjournals.org.
  8. ↑ "The search the world's first truly affordable dialysis machine". Abc.net.au. 16 March 2015. Retrieved 8 October 2017.
  9. ↑ Healy, Melissa (9 November 2015). "Getting your blood pressure even lower: Here are the risks and rewards". Los Angeles Times . Retrieved 8 October 2017.
  10. ↑ "Teacher turns lifesaver for pupil". Dailytelegraph.com.au. 21 March 2014. Retrieved 8 October 2017.
  11. ↑ "Vlado Perkovic - Google Scholar Citations". scholar.google.com. Retrieved 8 October 2017.
  12. 1 2 Search Results for author Perkovic V on PubMed .
  13. ↑ Perkovic, Vlado; Jardine, Meg J.; Neal, Bruce; Bompoint, Severine; Heerspink, Hiddo J.L.; Charytan, David M.; Edwards, Robert; Agarwal, Rajiv; Bakris, George; Bull, Scott; Cannon, Christopher P.; Capuano, George; Chu, Pei-Ling; De Zeeuw, Dick; Greene, Tom; Levin, Adeera; Pollock, Carol; Wheeler, David C.; Yavin, Yshai; Zhang, Hong; Zinman, Bernard; Meininger, Gary; Brenner, Barry M.; Mahaffey, Kenneth W.; CREDENCE Trial Investigators (2019). "Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy". New England Journal of Medicine. 380 (24): 2295–2306. doi:10.1056/NEJMoa1811744. hdl: 1805/22369 . PMID   30990260. S2CID   117730201.
  14. ↑ Perkovic, Vlado; Rodgers, Anthony (2015). "Redefining Blood-Pressure Targets — SPRINT Starts the Marathon". New England Journal of Medicine. 373 (22): 2175–8. doi:10.1056/NEJMe1513301. PMID   26551394.
  15. ↑ Liyanage, Thaminda; Ninomiya, Toshiharu; Jha, Vivekanand; Neal, Bruce; Patrice, Halle Marie; Okpechi, Ikechi; Zhao, Ming-hui; LV, Jicheng; Garg, Amit X; Knight, John; Rodgers, Anthony; Gallagher, Martin; Kotwal, Sradha; Cass, Alan; Perkovic, Vlado (2015). "Worldwide access to treatment for end-stage kidney disease: A systematic review". The Lancet. 385 (9981): 1975–82. doi:10.1016/S0140-6736(14)61601-9. PMID   25777665. S2CID   25200966.
  16. ↑ Kalantar-Zadeh K, Jafar TH, Nitsch D, Neuen BL, Perkovic V (28 August 2021). "Chronic Kidney Disease" (PDF). Lancet. 398 (10302): 786–802. doi:10.1016/S0140-6736(21)00519-5. PMID   34175022. S2CID   235631509.
  17. ↑ Perkovic, V; Cass, A (2010). "Glomerular filtration rate and the risk of stroke". BMJ. 341: c4390. doi:10.1136/bmj.c4390. PMID   20884697. S2CID   39211355.
  18. ↑ Palmer, Suetonia C; Di Micco, Lucia; Razavian, Mona; Craig, Jonathan C; Perkovic, Vlado; Pellegrini, Fabio; Copetti, Massimiliano; Graziano, Giusi; Tognoni, Gianni; Jardine, Meg; Webster, Angela; Nicolucci, Antonio; Zoungas, Sophia; Strippoli, Giovanni F.M (2012). "Effects of Antiplatelet Therapy on Mortality and Cardiovascular and Bleeding Outcomes in Persons with Chronic Kidney Disease". Annals of Internal Medicine. 156 (6): 445–59. doi:10.7326/0003-4819-156-6-201203200-00007. PMID   22431677.
  19. ↑ Perkovic, Vlado; Verdon, Christine; Ninomiya, Toshiharu; Barzi, Federica; Cass, Alan; Patel, Anushka; Jardine, Meg; Gallagher, Martin; Turnbull, Fiona; Chalmers, John; Craig, Jonathan; Huxley, Rachel (2008). "The Relationship between Proteinuria and Coronary Risk: A Systematic Review and Meta-Analysis". PLOS Medicine. 5 (10): e207. doi: 10.1371/journal.pmed.0050207 . PMC   2570419 . PMID   18942886.
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