ORC4

Last updated
ORC4
Identifiers
Aliases ORC4 , ORC4L, ORC4P, origin recognition complex subunit 4
External IDs OMIM: 603056 MGI: 1347043 HomoloGene: 8059 GeneCards: ORC4
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001177313
NM_011958
NM_001355296

RefSeq (protein)

NP_001170784
NP_036088
NP_001342225

Location (UCSC) Chr 2: 147.93 – 148.02 Mb Chr 2: 48.79 – 48.84 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Origin recognition complex subunit 4 is a protein that in humans is encoded by the ORC4 (ORC4L) gene. [5] [6] [7]

Contents

Function

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. It has been shown to form a core complex with ORC2L, -3L, and -5L. Three alternatively spliced transcript variants encoding the same protein have been reported. [7]

Interactions

ORC4 has been shown to interact with:

Related Research Articles

<span class="mw-page-title-main">MCM6</span>

DNA replication licensing factor MCM6 is a protein that in humans is encoded by the MCM6 gene. MCM6 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication.

<span class="mw-page-title-main">Eukaryotic DNA replication</span> DNA replication in eukaryotic organisms

Eukaryotic DNA replication is a conserved mechanism that restricts DNA replication to once per cell cycle. Eukaryotic DNA replication of chromosomal DNA is central for the duplication of a cell and is necessary for the maintenance of the eukaryotic genome.

<span class="mw-page-title-main">PPP2CA</span> Enzyme

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform is an enzyme that is encoded by the PPP2CA gene.

<span class="mw-page-title-main">MCM7</span> Protein-coding gene in the species Homo sapiens

DNA replication licensing factor MCM7 is a protein that in humans is encoded by the MCM7 gene.

<span class="mw-page-title-main">MCM2</span> Protein-coding gene in the species Homo sapiens

DNA replication licensing factor MCM2 is a protein that in humans is encoded by the MCM2 gene.

<span class="mw-page-title-main">MCM3</span> Protein-coding gene in the species Homo sapiens

DNA replication licensing factor MCM3 is a protein that in humans is encoded by the MCM3 gene.

<span class="mw-page-title-main">CDC6</span> Protein-coding gene in the species Homo sapiens

Cell division control protein 6 homolog is a protein that in humans is encoded by the CDC6 gene.

<span class="mw-page-title-main">MCM4</span> Protein-coding gene in the species Homo sapiens

DNA replication licensing factor MCM4 is a protein that in humans is encoded by the MCM4 gene.

<span class="mw-page-title-main">ORC2</span> Protein-coding gene in the species Homo sapiens

Origin recognition complex subunit 2 is a protein that is encoded by the ORC2 (ORC2L) gene in humans.

<span class="mw-page-title-main">RFC4</span> Protein-coding gene in the species Homo sapiens

Replication factor C subunit 4 is a protein that in humans is encoded by the RFC4 gene.

<span class="mw-page-title-main">RFC2</span> Protein-coding gene in the species Homo sapiens

Replication factor C subunit 2 is a protein that in humans is encoded by the RFC2 gene.

<span class="mw-page-title-main">Cell division cycle 7-related protein kinase</span> Protein-coding gene in the species Homo sapiens

Cell division cycle 7-related protein kinase is an enzyme that in humans is encoded by the CDC7 gene. The Cdc7 kinase is involved in regulation of the cell cycle at the point of chromosomal DNA replication. The gene CDC7 appears to be conserved throughout eukaryotic evolution; this means that most eukaryotic cells have the Cdc7 kinase protein.

<span class="mw-page-title-main">RFC5</span> Protein-coding gene in the species Homo sapiens

Replication factor C subunit 5 is a protein that in humans is encoded by the RFC5 gene.

<span class="mw-page-title-main">DBF4</span> Protein-coding gene in the species Homo sapiens

Protein DBF4 homolog A is a protein that is encoded by the DBF4 gene in humans.

<span class="mw-page-title-main">ORC6</span> Protein-coding gene in the species Homo sapiens

Origin recognition complex subunit 6 is a protein that in humans is encoded by the ORC6 (ORC6L) gene.

<span class="mw-page-title-main">ORC5</span> Protein-coding gene in the species Homo sapiens

Origin recognition complex subunit 5 is a protein that in humans is encoded by the ORC5 (ORC5L) gene.

<span class="mw-page-title-main">ORC3</span> Protein-coding gene in the species Homo sapiens

Origin recognition complex subunit 3 is a protein that in humans is encoded by the ORC3 (ORC3L) gene.

<span class="mw-page-title-main">MED30</span> Protein-coding gene in the species Homo sapiens

Mediator of RNA polymerase II transcription subunit 30 is an enzyme that in humans is encoded by the MED30 gene. It represents subunit Med30 of the Mediator complex and is metazoan-specific, having no homologues in yeasts.

<span class="mw-page-title-main">ORC1</span> Protein-coding gene in the species Homo sapiens

Origin recognition complex subunit 1 is a protein that in humans is encoded by the ORC1 gene. It is closely related to CDC6, and both are the same protein in archaea.

<span class="mw-page-title-main">Replication protein A3</span> Protein-coding gene in the species Homo sapiens

Replication protein A 14 kDa subunit is a protein that in humans is encoded by the RPA3 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000115947 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026761 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 Quintana DG, Hou ZH, Thome KC, Hendricks M, Saha P, Dutta A (Nov 1997). "Identification of HsORC4, a member of the human origin of replication recognition complex". The Journal of Biological Chemistry. 272 (45): 28247–51. doi: 10.1074/jbc.272.45.28247 . PMID   9353276.
  6. Eki T, Dean FB, Kohda A, Okumura K, Abe M, Murakami Y, Ishiai M, Satomoto K, Hurwitz J, O'Donnell M, Hanaoka F (October 1998). "Assignment of the homologue of the yeast origin recognition complex subunit ORC4 (ORC4L) to human chromosome band 2q22→q23 by in situ hybridization and somatic cell hybrid analysis". Cytogenetics and Cell Genetics. 81 (1): 89–90. doi:10.1159/000014997. PMID   9691185. S2CID   46878915.
  7. 1 2 "Entrez Gene: ORC4L origin recognition complex, subunit 4-like (yeast)".
  8. 1 2 3 4 5 6 7 8 Kneissl M, Pütter V, Szalay AA, Grummt F (Mar 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". Journal of Molecular Biology. 327 (1): 111–28. doi:10.1016/s0022-2836(03)00079-2. PMID   12614612.
  9. 1 2 3 Dhar SK, Delmolino L, Dutta A (Aug 2001). "Architecture of the human origin recognition complex". The Journal of Biological Chemistry. 276 (31): 29067–71. doi: 10.1074/jbc.M103078200 . PMID   11395502.
  10. 1 2 Vashee S, Simancek P, Challberg MD, Kelly TJ (Jul 2001). "Assembly of the human origin recognition complex". The Journal of Biological Chemistry. 276 (28): 26666–73. doi: 10.1074/jbc.M102493200 . PMID   11323433.
  11. Pinto S, Quintana DG, Smith P, Mihalek RM, Hou ZH, Boynton S, Jones CJ, Hendricks M, Velinzon K, Wohlschlegel JA, Austin RJ, Lane WS, Tully T, Dutta A (May 1999). "latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant". Neuron. 23 (1): 45–54. doi: 10.1016/s0896-6273(00)80752-7 . PMID   10402192. S2CID   781511.
  12. Quintana DG, Thome KC, Hou ZH, Ligon AH, Morton CC, Dutta A (Oct 1998). "ORC5L, a new member of the human origin recognition complex, is deleted in uterine leiomyomas and malignant myeloid diseases". The Journal of Biological Chemistry. 273 (42): 27137–45. doi: 10.1074/jbc.273.42.27137 . PMID   9765232.

Further reading