Sapio Sciences

Last updated
Sapio Sciences LLC
Founded2004;20 years ago (2004)
Headquarters
Baltimore, MD
,
United States
ProductsLaboratory Management software
Website www.sapiosciences.com

Sapio Sciences is a technology company that develops software to support drug research and discovery processes. Founded by Kevin Cramer, Sapio Sciences has developed software products for laboratory operations, particularly in biotechnology and chemistry. [1]

Contents

History

Sapio Sciences was founded in 2004 to develop software tools to address the growing genotyping need for tools to assist in analyzing genetics data, particularly in relation to Genome Wide Association Studies. Sapio's Exemplar Analytics software grew to incorporate over 50 different algorithms. Sapio was subsequently approached by customers to develop a Laboratory Information Management System (LIMS). This led to the development of Exemplar LIMS in June 2007 by Kevin Cramer with several extensions since then. [2] [3] The company targets highly regulated environments such as part 11, GLP and CLIA laboratories. [4] Kevin Cramer has a background in Information Systems from York College, PA. He has co-authored multiple papers in Nature Genetics, applying statistical and machine learning methodologies to genetic data interpretation. [5]

In 2013, Sapio Sciences launched Web Client 1.0. Sapio was then the first to integrate a full-featured, web-based Electronic Lab Notebook with its LIMS (Laboratory Information Management System) built together on a single software platform in 2017. [6]

In 2020 the company launched a new Sapio Platform that extended its core platform with additional modules for data analysis and knowledge extraction. [7] [3] The Sapio Platform was iterated on to add templated modules for different life sciences applications, including biotechnology research, next-generation sequencing (NGS), bioanalysis, etc. [8] [9] [10] [11] [12]

In the summer of 2023, NatureMetrics selected Sapio LIMS to enable environmental DNA sequencing. [13] In 2023, Oxford Biomedica selected Sapio ELN for its cell and gene therapy research and development business. [14] In 2023, Immunebridge announced it had selected the Sapio Electronic Lab Notebook to modernize its enterprise data management for its work on NK cell-based immunotherapies. [15] In November 2023, Sapio Sciences became the first company to introduce an AI-Chat Scientific Assistant integrated directly into an Electronic Laboratory Notebook (ELN), called ELaiN (Electronic Lab Artificially Intelligent Notebook). [16] [17]

Operations

Sapio Sciences is focused on expediting drug discovery processes through its unified lab platform that has built-in science applications and data management tools, including web client, data designer, and a workflow engine, among other tools. Kevin Cramer is the founder and CEO. [18]

Products

Exemplar was introduced in 2007 as a LIMS and electronic laboratory notebook product. [19] The software was subsequently expanded to perform additional tasks. [20]

Workflow and data tracking features were introduced in 2008 to allow the software to be used for Scientific Data Management (SDMS). [21] Statistics have also be implemented to perform detailed analysis of scientific data within the same environment. [22]

Biomarker discovery

Sapio extended its software with features for biomarker discovery including features for managing clinical study data, treatment groups data, subject data, sample data and assay data from diverse assays such as Immunohistochemistry, Western Blot, PCR, etc. Basic data mining and statistical analysis tools are included for tasks such as data normalization, logistic regression, ANOVA and genetic algorithms.

Molecular diagnostics

Sapio introduced the Exemplar [23] Dx LIMS product for molecular diagnostic companies that is optimised to handle diagnostic test request and results. In addition to sample management and protocol tracking, it emphasises kit and instrument integration with Dx platforms such as Qiagen and Beckman Coulter. [24] Physicians can be presented a web interface for test ordering, or test requests can be imported using the HL7 format. Assay data is then managed in Exemplar and the Dx companies custom algorithms can be implemented to analyze the data and produce the diagnostic report automatically. This report, once electronically signed off, is then delivered via the web, secure fax, HL7 or secure email to the requesting physician. [25]

Related Research Articles

<span class="mw-page-title-main">Agilent Technologies</span> American technology company

Agilent Technologies, Inc. is a global company headquartered in Santa Clara, California, that provides instruments, software, services, and consumables for laboratories. Agilent was established in 1999 as a spin-off from Hewlett-Packard. The resulting IPO of Agilent stock was the largest in the history of Silicon Valley at the time. From 1999 to 2014, the company produced optics, semiconductors, EDA software and test and measurement equipment for electronics; that division was spun off to form Keysight. Since then, the company has continued to expand into pharmaceutical, diagnostics & clinical, and academia & government (research) markets.

<span class="mw-page-title-main">Symyx Technologies</span>

Symyx Technologies, Inc. was a company that specialized in informatics and automation products. Symyx provided software solutions for scientific research, including Enterprise Laboratory Notebooks and products for combinatorial chemistry. The software part of the business became part of Accelrys, Inc. in 2010 and then in 2014 this company merged with Dassault Systèmes. Symyx also offered laboratory robotics systems for performing automated chemical research, which in 2010 was spun out as Freeslate, Inc.

<span class="mw-page-title-main">Educational software</span> Software intended for an educational purpose

Educational software is a term used for any computer software that is made for an educational purpose. It encompasses different ranges from language learning software to classroom management software to reference software. The purpose of all this software is to make some part of education more effective and efficient.

<span class="mw-page-title-main">Laboratory information management system</span> Software infrastructure for improving research and storing data

A laboratory information management system (LIMS), sometimes referred to as a laboratory information system (LIS) or laboratory management system (LMS), is a software-based solution with features that support a modern laboratory's operations. Key features include—but are not limited to—workflow and data tracking support, flexible architecture, and data exchange interfaces, which fully "support its use in regulated environments". The features and uses of a LIMS have evolved over the years from simple sample tracking to an enterprise resource planning tool that manages multiple aspects of laboratory informatics.

An electronic lab notebook is a computer program designed to replace paper laboratory notebooks. Lab notebooks in general are used by scientists, engineers, and technicians to document research, experiments, and procedures performed in a laboratory. A lab notebook is often maintained to be a legal document and may be used in a court of law as evidence. Similar to an inventor's notebook, the lab notebook is also often referred to in patent prosecution and intellectual property litigation.

The Clinical Data Interchange Standards Consortium (CDISC) is a standards developing organization (SDO) dealing with medical research data linked with healthcare, to "enable information system interoperability to improve medical research and related areas of healthcare". The standards support medical research from protocol through analysis and reporting of results and have been shown to decrease resources needed by 60% overall and 70–90% in the start-up stages when they are implemented at the beginning of the research process.

Laboratory informatics is the specialized application of information technology aimed at optimizing and extending laboratory operations. It encompasses data acquisition, instrument interfacing, laboratory networking, data processing, specialized data management systems, a laboratory information management system, scientific data management, and knowledge management. It has become more prevalent with the rise of other "informatics" disciplines such as bioinformatics, cheminformatics and health informatics. Several graduate programs are focused on some form of laboratory informatics, often with a clinical emphasis. A closely related - some consider subsuming - field is laboratory automation.

MDL Information Systems, Inc. was a provider of R&D informatics products for the life sciences and chemicals industries. The company was launched as a computer-aided drug design firm in January 1978 in Hayward, California. The company was acquired by Symyx Technologies, Inc. in 2007. Subsequently Accelrys merged with Symyx. The Accelrys name was retained for the combined company. In 2014 Accelrys was acquired by Dassault Systemes. The Accelrys business unit was renamed BIOVIA.

<span class="mw-page-title-main">Laboratory automation</span> Process improvement strategy for routine procedures

Laboratory automation is a multi-disciplinary strategy to research, develop, optimize and capitalize on technologies in the laboratory that enable new and improved processes. Laboratory automation professionals are academic, commercial and government researchers, scientists and engineers who conduct research and develop new technologies to increase productivity, elevate experimental data quality, reduce lab process cycle times, or enable experimentation that otherwise would be impossible.

BIOVIA is a software company headquartered in the United States, with representation in Europe and Asia. It provides software for chemical, materials and bioscience research for the pharmaceutical, biotechnology, consumer packaged goods, aerospace, energy and chemical industries.

<span class="mw-page-title-main">Thermo Fisher Scientific</span> Provisioner of scientific consumables, equipment, and services

Thermo Fisher Scientific Inc. is an American supplier of analytical instruments, life sciences solutions, specialty diagnostics, laboratory, pharmaceutical and biotechnology services. Based in Waltham, Massachusetts, Thermo Fisher was formed through the merger of Thermo Electron and Fisher Scientific in 2006. Thermo Fisher Scientific has acquired other reagent, consumable, instrumentation, and service providers, including Life Technologies Corporation (2013), Alfa Aesar (2015), Affymetrix (2016), FEI Company (2016), BD Advanced Bioprocessing (2018), and PPD (2021).

STARLIMS Corporation (Starlims) is a portfolio company of Francisco Partners that provides web-based laboratory information management systems.

<span class="mw-page-title-main">Collaborative Drug Discovery</span>

Collaborative Drug Discovery (CDD) is a software company founded in 2004 as a spin-out of Eli Lilly by Barry Bunin, PhD. CDD utilizes a web-based database solution for managing drug discovery data, primarily through the CDD Vault product which is focused around small molecules and associated bio-assay data. In 2021, CDD launched its first commercial data offering, PharmaKB, formerly BioHarmony, as The Pharma KnowledgeBase, which is centered around pharma company, drug, and disease information for research, business intelligence, and investors.

<span class="mw-page-title-main">LabLynx</span>

LabLynx, Inc. is a privately owned, funded, and managed American corporation that develops, supports, and markets laboratory information management system (LIMS) solutions. Its primary offerings over the years have included webLIMS and ELab. The company’s primary clients include laboratories in the agriculture, clinical, environmental, forensics, health care, and manufacturing industries, including government agencies. The company is known for introducing one of the first browser-based LIMS products in 1997 and being in the laboratory informatics industry for decades.

Dotmatics is an R&D scientific software company used by scientists in the R&D process that help them be more efficient in their efforts to innovate. Founded in 2005, the company's primary office is in Boston with 14 offices around the globe. In March 2021, Insightful Science acquired Dotmatics. In April 2022, the two companies consolidated under the Dotmatics brand with Insightful Science CEO Thomas Swalla leading the new Dotmatics. Dotmatics' software is used by 2 million scientists and researchers and 10,000 customers.

LabWare, Inc. is an American developer of laboratory informatics software, such as laboratory information management systems, electronic laboratory notebooks and laboratory data analytics. It is a Delaware corporation, with offices in Wilmington, Delaware.

LabArchives is a line of cloud-based electronic lab notebooks (ELNs) sold by LabArchives, LLC, which was founded in 2009 by Earl B. Beutler and Kirk Schneider.

Sophia Genetics is a data-driven medicine software company with headquarters in Lausanne, Switzerland and Boston, Massachusetts. It provides genomic and radiomic analysis for hospitals, laboratories, and biopharma institutions. The company was ranked among the 50 smartest companies by the MIT Technology Review in 2017. The company went public on the Nasdaq in 2021, floating at $1.1B.

LigoLab Information System is an American software company that provides software and laboratory operating systems for clinical laboratories. LigoLab develops and distributes the software tool TestDirectly, which is used for COVID-19 testing. It is based in Glendale, California.

References

  1. ↑ Godswill, Ntsomboh Ntsefong (2015). Innovative and Efficient Laboratory Management. Xlibris US. pp. 62–65. ISBN   9781503564367.
  2. ↑ Strebig, Neil (2019-01-16). "York, Pa., surges with success built on much more than bars and restaurants". York Daily Record. Retrieved 2024-04-19.
  3. 1 2 Thurow, Kerstin; Junginger, Steffen (2022). Devices and Systems for Laboratory Automation. Wiley (published August 3, 2022). pp. 462–466. ISBN   9783527348329.{{cite book}}: CS1 maint: date and year (link)
  4. ↑ "ExonHit Bets on Sapio LIMS". Bio-IT World. Retrieved 2012-10-26.
  5. ↑ Hanlon, Rebecca (2021-09-21). "Entrepreneur with two tech companies downtown asks, 'Why not York?'". The Founder Beat. Retrieved 2024-04-19.
  6. ↑ "Exemplar LIMS Web Client 1.0 | Scientific Computing World". www.scientific-computing.com. Retrieved 2024-04-19.
  7. ↑ D. Hanton, Scott; F. Conway, John; Rivero, Ralph; Baumes, Laurent (2020-12-10). "High Throughput Experimentation Drives Better Outcomes". Lab Manager. Retrieved 2024-04-19.
  8. ↑ "Norwich COVID-19 testing initiative pilot: evaluating the feasibility of asymptomatic testing on a university campus". academic.oup.com. 2020-10-30. Retrieved 2024-04-19.
  9. ↑ Wallace, Andrew J. (2016-08-12). "New challenges for BRCA testing: a view from the diagnostic laboratory". European Journal of Human Genetics. 24 (1): S10–S18. doi:10.1038/ejhg.2016.94. ISSN   1476-5438. PMC   5141576 .
  10. ↑ Bergeron-Sawitzke, Julie; Gold, Bert; Olsh, Adam; Schlotterbeck, Sarah; Lemon, Kendal; Visvanathan, Kala; Allikmets, Rando; Dean, Michael (2009-03-04). "Multilocus analysis of age-related macular degeneration". European Journal of Human Genetics. 17 (9): 1190–1199. doi:10.1038/ejhg.2009.23. ISSN   1476-5438. PMC   2729805 . PMID   19259132.
  11. ↑ Brusie, Chaunie (2019-04-20). "Sapio Sciences Launches Expanded Laboratory Informatics Platform". Clinical Lab Products. Retrieved 2024-04-19.
  12. ↑ "Sapio Sciences announces full GxP validation of its unified laboratory informatics platform and suite of solutions". ITDigest. 2024-01-12. Retrieved 2024-04-19.
  13. ↑ "NatureMetrics selects Sapio Science's platform for DNA monitoring". NS Healthcare. 2023-07-06. Retrieved 2024-04-19.
  14. ↑ "Oxford Biomedica Implements Sapio Sciences' Electronic Laboratory Notebook". Contract Pharma. Retrieved 2024-04-19.
  15. ↑ "ImmuneBridge Chooses Sapio Sciences Electronic Lab Notebook to Modernize and Scale Enterprise Data Management". BioSpace. Retrieved 2024-04-19.
  16. ↑ "Sapio Sciences – A comprehensive AI assistant for scientists". califesciences.org. Retrieved 2024-04-19.
  17. ↑ "The Digital Lab. "What it is and How we get there"". bio-itworldexpo.com. 2020-10-01. Retrieved 2024-04-19.
  18. ↑ Haber, Gary (2015-09-14). "Sapio Sciences, a software company, moves into former York Dispatch building". York Daily Record. Retrieved 2024-04-19.
  19. ↑ "Compare Nautilus LIMS vs. Sapio LIMS in 2024". slashdot.org. Retrieved 2024-04-19.
  20. ↑ Lukoseviciute, M.; Holzhauser, S.; Pappa, E.; Mandal, T.; Dalianis, T.; Kostopoulou, O. N. (2023). "Efficacy of combined targeted therapy with PI3K and CDK4/6 or PARP and WEE1 inhibitors in neuroblastoma cell lines". Oncology Reports. 50 (3): 166. doi:10.3892/or.2023.8603. PMC   10394730 . PMID   37477144.
  21. ↑ "Sapio Sciences Exemplar LIMS 4.0". Scientificcomputing.com. 2010-06-16. Archived from the original on 2012-03-11. Retrieved 2012-10-26.
  22. ↑ "Genseq wählt Sapio LIMS für erstklassige Next-Generation-Sequenzierungsdienste". www.pharma-zeitung.de. Retrieved 2024-04-19.
  23. ↑ Hu, Hai; Mural, Richard J.; Liebman, Michael N. (2008). Biomedical Informatics in Translational Research. Artech House. ISBN   978-1-59693-039-1.
  24. ↑ "Sapio Granted Full GxP Validation of Lab Informatics Platform". Contract Pharma. Retrieved 2024-04-19.
  25. ↑ "Sapio Sciences gibt die vollständige GxP-Validierung seiner einheitlichen Laborinformatik-Plattform und seiner Lösungspalette bekannt". www.pharma-zeitung.de. Retrieved 2024-04-19.
This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.