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A pandemic is an epidemic of an infectious disease that has spread across a large region, for instance multiple continents or worldwide, affecting a substantial number of individuals. Widespread endemic diseases with a stable number of infected individuals such as recurrences of seasonal influenza are generally excluded as they occur simultaneously in large regions of the globe rather than being spread worldwide.
An epidemic is the rapid spread of disease to a large number of hosts in a given population within a short period of time. For example, in meningococcal infections, an attack rate in excess of 15 cases per 100,000 people for two consecutive weeks is considered an epidemic.
The 1918–1920 flu pandemic, also known as the Great Influenza epidemic or by the common misnomer Spanish flu, was an exceptionally deadly global influenza pandemic caused by the H1N1 influenza A virus. The earliest documented case was March 1918 in the state of Kansas in the United States, with further cases recorded in France, Germany and the United Kingdom in April. Two years later, nearly a third of the global population, or an estimated 500 million people, had been infected in four successive waves. Estimates of deaths range from 17 million to 50 million, and possibly as high as 100 million, making it one of the deadliest pandemics in history.
The Hong Kong flu, also known as the 1968 flu pandemic, was a flu pandemic whose outbreak in 1968 and 1969 killed between one and four million people globally. It is among the deadliest pandemics in history, and was caused by an H3N2 strain of the influenza A virus. The virus was descended from H2N2 through antigenic shift, a genetic process in which genes from multiple subtypes are reassorted to form a new virus.
Flu season is an annually recurring time period characterized by the prevalence of an outbreak of influenza (flu). The season occurs during the cold half of the year in each hemisphere. It takes approximately two days to show symptoms. Influenza activity can sometimes be predicted and even tracked geographically. While the beginning of major flu activity in each season varies by location, in any specific location these minor epidemics usually take about three weeks to reach its pinnacle, and another three weeks to significantly diminish.
An influenza pandemic is an epidemic of an influenza virus that spreads across a large region and infects a large proportion of the population. There have been six major influenza epidemics in the last 140 years, with the 1918 flu pandemic being the most severe; this is estimated to have been responsible for the deaths of 50–100 million people. The 2009 swine flu pandemic resulted in under 300,000 deaths and is considered relatively mild. These pandemics occur irregularly.
Influenza, commonly known as "the flu" or just "flu", is an infectious disease caused by influenza viruses. Symptoms range from mild to severe and often include fever, runny nose, sore throat, muscle pain, headache, coughing, and fatigue. These symptoms begin from one to four days after exposure to the virus and last for about 2–8 days. Diarrhea and vomiting can occur, particularly in children. Influenza may progress to pneumonia, which can be caused by the virus or by a subsequent bacterial infection. Other complications of infection include acute respiratory distress syndrome, meningitis, encephalitis, and worsening of pre-existing health problems such as asthma and cardiovascular disease.
The 2009 swine flu pandemic, caused by the H1N1/swine flu/influenza virus and declared by the World Health Organization (WHO) from June 2009 to August 2010, is the third recent flu pandemic involving the H1N1 virus. The first known human case was in La Gloria, Mexico, a rural town in Veracruz. The virus appeared to be a new strain of H1N1 that resulted from a previous triple reassortment of bird, swine, and human flu viruses which further combined with a Eurasian pig flu virus, leading to the term "swine flu".
The 2009 flu pandemic was a global outbreak of a new strain of influenza A virus subtype H1N1, first identified in April 2009, termed Pandemic H1N1/09 virus by the World Health Organization (WHO) and colloquially called swine flu. The outbreak was first observed in Mexico, and quickly spread globally. On the 11th of June 2009, the WHO declared the outbreak to be a pandemic. The overwhelming majority of patients experience mild symptoms, but some persons are at higher risk of suffering more serious effects; such as those with asthma, diabetes, obesity, heart disease, or those who are pregnant or have a weakened immune system. In the rare severe cases, around 3–5 days after symptoms manifest, the sufferer's condition declines quickly, often to the point respiratory failure. Although Ukraine was not (very) affected at first there was on outbreak of the virus in Western Ukraine in early November 2009 that led to the closing of public buildings and cancellation of meetings for three weeks.
During the 1972–1973 flu season in the Northern Hemisphere, a new variant of influenza, dubbed the 'London flu' by the press in the United States, was responsible for epidemics in many countries. 'London flu' was caused by a variant of influenza A/H3N2 that was first isolated in India in mid-1971 but only identified as a distinct strain in England in January, 1972.
The 1889–1890 pandemic, often referred to as the "Asiatic flu" or "Russian flu", was a worldwide respiratory viral pandemic. It was the last great pandemic of the 19th century, and is among the deadliest pandemics in history. The pandemic killed about 1 million people out of a world population of about 1.5 billion. The most reported effects of the pandemic took place from October 1889 to December 1890, with recurrences in March to June 1891, November 1891 to June 1892, the northern winter of 1893–1894, and early 1895.
This is a timeline of influenza, briefly describing major events such as outbreaks, epidemics, pandemics, discoveries and developments of vaccines. In addition to specific year/period-related events, there is the seasonal flu that kills between 250,000 and 500,000 people every year and has claimed between 340 million and 1 billion human lives throughout history.
Neil Morris Ferguson is a British epidemiologist and professor of mathematical biology, who specialises in the patterns of spread of infectious disease in humans and animals. He is the director of the Jameel Institute, and of the MRC Centre for Global Infectious Disease Analysis, and head of the Department of Infectious Disease Epidemiology in the School of Public Health and Vice-Dean for Academic Development in the Faculty of Medicine, all at Imperial College London.
In 1510, an acute respiratory disease emerged in Asia before spreading through North Africa and Europe during the first chronicled, inter-regional flu pandemic generally recognized by medical historians and epidemiologists. Influenza-like illnesses had been documented in Europe since at least Charlemagne, with 1357's outbreak the first to be called influenza, but the 1510 flu pandemic is the first to be pathologically described following communication advances brought about by the printing press. Flu became more widely referred to as coqueluche and coccolucio in France and Sicily during this pandemic, variations of which became the most popular names for flu in early modern Europe. The pandemic caused significant disruption in government, church, and society with near-universal infection and a mortality rate of around 1%.
In 1557, a pandemic strain of influenza emerged in Asia, then spread to Africa, Europe, and eventually the Americas. This flu was highly infectious and presented with intense, occasionally lethal symptoms. Medical historians like Thomas Short, Lazare Rivière and Charles Creighton gathered descriptions of catarrhal fevers recognized as influenza by modern physicians attacking populations with the greatest intensity between 1557 and 1559. The 1557 flu saw governments, for possibly the first time, inviting physicians to instill bureaucratic organization into epidemic responses. It is also the first pandemic where influenza is pathologically linked to miscarriages, given its first English names, and is reliably recorded as having spread globally. Influenza caused higher burial rates, near-universal infection, and economic turmoil as it returned in repeated waves.
In 1580 a severe influenza pandemic was recorded on several continents. The virus originated in Asia and spread along the Silk Road through the Middle East into Europe and Africa, where newly established maritime trade routes and moving armies facilitated its worldwide spread. Contemporary historian Johann Boekel wrote that it spread over all of Europe in six weeks, in which thousands died and nearly everyone was infected. Those who witnessed the epidemic variously called the disease nicknames like coqueluche,Shaufkrankeit,castrone, or variations of catarrh or fever. Physicians of the time increasingly appreciated that "epidemic catarrhs" were being directly caused by a contagious agent instead of the stars or environment.
The 1957–1958 Asian flu pandemic was a global pandemic of influenza A virus subtype H2N2 that originated in Guizhou in Southern China. The number of excess deaths caused by the pandemic is estimated to be 1–4 million around the world, making it one of the deadliest pandemics in history. A decade later, a reassorted viral strain H3N2 further caused the Hong Kong flu pandemic (1968–1969).
1918 flu pandemic in India was the outbreak of an unusually deadly influenza pandemic in British India between 1918 and 1920 as a part of the worldwide Spanish flu pandemic. Also referred to as the Bombay Influenza or the Bombay Fever in India, the pandemic is believed to have killed up to 17–18 million people in the country, the most among all countries. David Arnold (2019) estimates at least 12 million dead, about 5% of the population. The decade between 1911 and 1921 was the only census period in which India's population fell, mostly due to devastation of the Spanish flu pandemic. The death toll in India's British-ruled districts was 13.88 million.
In 1626 an influenza pandemic spread from Asia to Europe, Africa, North America, and South America during the first such pandemic of the seventeenth century.
Between the fall of 1789 and the spring of 1790, influenza occurred extensively throughout the United States and North America more broadly. First reported in the southern United States in September, it spread throughout the northern states in October and November, appeared about the same time in the West Indies, and reached as far north as Nova Scotia before the end of 1789. In the spring of 1790, a renewed epidemic developed, almost as universal as the first but more often fatal.
References
- ↑ Morens, David M.; Taubenberger, Jeffery K. (September 2011). "Pandemic influenza: certain uncertainties". Reviews in Medical Virology. 21 (5): 262–284. doi:10.1002/rmv.689. ISSN 1052-9276. PMC 3246071 . PMID 21706672.
- 1 2 "Influensa, ryska snuvan, spanska sjukan". www.landberga.se. Retrieved 2021-01-15.
- ↑ Hart, Ernest, ed. (1880). British Medical Journal. London: British Medical Association. p. 159.
- ↑ Moore, Sir John William (1892). Text-book of the Eruptive and Continued Fevers. New York: Fannin. p. 20.
- ↑ Grant, William (1782). Observations on the Late Influenza the Febris Catarrhalis Epidemica of Hippocrates: As it Appeared at London in 1775 & 1782. London: T. Cadel. pp. i–ii.
- ↑ The Dublin Journal of Medical Science. Dublin: Fannin & Company. 1880. p. 98.