| Singles | |
|---|---|
| 2006 Fortis Championships Luxembourg | |
| Champion |  Alona Bondarenko |
| Runner-up |  Francesca Schiavone |
| Final score | 6–3, 6–2 |
| Seeds | 8 |
Kim Clijsters was the defending champion, but did not compete this year.
Unseeded Alona Bondarenko won the title by defeating Francesca Schiavone 6–3, 6–2 in the final.
The top four seeds received a bye into the second round.
Elena Dementieva (quarterfinals) Nadia Petrova (second round)
Patty Schnyder (quarterfinals) Dinara Safina (quarterfinals) Francesca Schiavone (final)
Ana Ivanovic (first round)
Anna-Lena Grönefeld (first round)
Mary Pierce (first round)| Semifinals | Final | ||||||||||||
| Q |  Agnieszka Radwańska | 5 | 6 | 1 | |||||||||
| 5 | Francesca Schiavone | 7 | 2 | 6 | |||||||||
| 5 | Francesca Schiavone | 3 | 2 | ||||||||||
| Alona Bondarenko | 6 | 6 | |||||||||||
 Květa Peschke | 3 | 7 | 5 | ||||||||||
| Alona Bondarenko | 6 | 5 | 7 | ||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| WC/1 | E Dementieva | 7 | 5 | ||||||||||||||||||||||||
| WC |  A Kremer | 1 | 4 |  S Stosur | 5 | 1 | |||||||||||||||||||||
| S Stosur | 6 | 6 | WC/1 | E Dementieva | 5 | 2 | |||||||||||||||||||||
| M Santangelo | 7 | 68 | 3 | Q | A Radwańska | 7 | 6 | ||||||||||||||||||||
| Q | A Radwańska | 5 | 710 | 6 | Q | A Radwańska | 6 | 6 | |||||||||||||||||||
 V Williams | 6 | 6 | V Williams | 3 | 0 | ||||||||||||||||||||||
| 6 | A Ivanovic | 3 | 4 | Q | A Radwańska | 5 | 6 | 1 | |||||||||||||||||||
| 5 | F Schiavone | 7 | 2 | 6 | |||||||||||||||||||||||
| 3 | P Schnyder | 6 | 6 | ||||||||||||||||||||||||
| M Müller | 3 | 0 | WC | C Rubin | 0 | 3 | |||||||||||||||||||||
| WC | C Rubin | 6 | 6 | 3 | P Schnyder | 1 | 1 | ||||||||||||||||||||
| Q | T Malek | 4 | 3 | 5 | F Schiavone | 6 | 6 | ||||||||||||||||||||
| Q | R Vinci | 6 | 6 | Q | R Vinci | 2 | 1 | ||||||||||||||||||||
 M Krajicek | 4 | 3 | 5 | F Schiavone | 6 | 6 | |||||||||||||||||||||
| 5 | F Schiavone | 6 | 6 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 7 | A-L Grönefeld | 0 | 4 | ||||||||||||||||||||||||
| Q | K Knapp | 6 | 6 | Q | K Knapp | 4 | 4 | ||||||||||||||||||||
| K Peschke | 7 | 6 | K Peschke | 6 | 6 | ||||||||||||||||||||||
| J Schruff | 5 | 1 | K Peschke | 6 | 6 | ||||||||||||||||||||||
 D Hantuchová | 77 | 6 | 4 | D Safina | 4 | 3 | |||||||||||||||||||||
| T Golovin | 61 | 3 | D Hantuchová | 5 | 3 | ||||||||||||||||||||||
| 4 | D Safina | 7 | 6 | ||||||||||||||||||||||||
| K Peschke | 3 | 7 | 5 | ||||||||||||||||||||||||
| 8 | M Pierce | 3 | 3 | A Bondarenko | 6 | 5 | 7 | ||||||||||||||||||||
| A Bondarenko | 6 | 6 | A Bondarenko | 4 | 6 | 6 | |||||||||||||||||||||
 K Srebotnik | 6 | 6 | K Srebotnik | 6 | 4 | 3 | |||||||||||||||||||||
| ME Camerin | 4 | 1 | A Bondarenko | 5 | 6 | 6 | |||||||||||||||||||||
| N Dechy | 6 | 3 | 6 | N Dechy | 7 | 4 | 0 | ||||||||||||||||||||
 S Bammer | 1 | 6 | 3 | N Dechy | 6 | 6 | |||||||||||||||||||||
| 2 | N Petrova | 4 | 3 | ||||||||||||||||||||||||
Anna Chakvetadze was the defending champion, but lost in the quarterfinals to Marion Bartoli.
Vera Zvonareva was the defending champion, but was sidelined due to an ankle injury.
Pauline Parmentier was the defending champion, but she was defeated in the second round by Magdaléna Rybáriková.
Maria Kirilenko was the defending champion but lost in the semifinals against Kimiko Date-Krumm.
Kimiko Date-Krumm won in the final 6–3, 6–3 against Anabel Medina Garrigues.
Jelena Janković was the defending champion, but she lost in the quarterfinals to Alisa Kleybanova.
Roberta Vinci was the defending champion, but lost in the final to Francesca Schiavone, 6–1, 6–1.
Francesca Schiavone won her first and only Grand Slam singles title, defeating first-time Grand Slam finalist Samantha Stosur, 6–4, 7–6(7–2), to win the women's singles tennis title at the 2010 French Open, in a repeat of their last year's first round match. Schiavone thus became the first Italian woman to win a Grand Slam tournament, and the first woman in the Open Era to win the French Open while seeded outside the top 10. The final was the first since the 2004 tournament where both players were appearing in their first Grand Slam singles final. Schiavone remains the last woman with a one-handed backhand to win a grand slam tournament on the woman's tour. In virtue of her victory, Schiavone also made the top 10 for the first time, debuting at No. 6.
Svetlana Kuznetsova was the defending champion, but had to withdraw due to a back injury.
Alicia Molik was the defending champion, but was unable to compete due to vestibular neuronitis.
Kiki Bertens was the defending champion, but lost in the quarterfinals to Lourdes Domínguez Lino.
Francesca Schiavone won the title, defeating Domínguez Lino in the final, 6–1, 6–3.
Francesca Schiavone was the defending champion, but lost in the first round to Beatriz García Vidagany.
Elena Vesnina was the defending champion, but lost in the second round to Madison Keys.
Lindsay Davenport was the defending champion, but lost to Maria Sharapova in the semifinals.
Lindsay Davenport was the defending champion, but could not participate due to a back injury.
Patty Schnyder was the defending champion, but lost in quarterfinals to Lucie Šafářová.
Dominika Cibulková was the defending champion, but lost in the second round to Heather Watson.
Anke Huber was the defending champion, but lost in quarterfinals to Gala León García.
Serena Williams won the title by defeating Jennifer Capriati 6–2, 4–6, 6–4 in the final.
Justine Henin-Hardenne was the defending champion and successfully defended her title, by defeating Svetlana Kuznetsova 7–6(7–3), 6–3 in the final.
Anna Smashnova was the defending champion, but chose not to compete in 2003.