The last four stages of the 2008 Copa Santander Libertadores are the knockout stages: the Round of 16, the Quarterfinals, the Semifinals, and the Finals.
The remaining stages of the tournament constitute a single-elimination tournament. In each stage, the teams will play an opponent in a two-legged tie on a home-away basis. Each team will earn three points for a win, one point for a draw, and zero points for a loss. The team with the most points at the end of each tie will advance.
The following criteria will be used for breaking ties on points :
The 16 qualified teams in the knockout round will be seeded according to their results in the group stage. The top teams from each group are seeded 1–8, with the team with the most points as seed 1 and the team with the least as seed 8. The second-best teams from each group are seeded 9–16, with the team with the most points as seed 9 and the team with the least as seed 16. Teams with a higher seed will play the second leg of each tie at home.
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| Round of 16 | Quarterfinals | Semifinals | Finals | ||||||||||||||||||||||||
| 1 | | 2 | 1 | 3 | |||||||||||||||||||||||
| 16 | | 1 | 0 | 1 | |||||||||||||||||||||||
| 1 | | 0 | 3 | 3 | |||||||||||||||||||||||
| 8 | | 1 | 1 | 2 | |||||||||||||||||||||||
| 8 | | 0 | 2 | 2 | |||||||||||||||||||||||
| 9 | | 0 | 0 | 0 | |||||||||||||||||||||||
| 1 | | 2 | 3 | 5 | |||||||||||||||||||||||
| 12 | | 2 | 1 | 3 | |||||||||||||||||||||||
| 5 | | 1 | 1 | 2 | |||||||||||||||||||||||
| 12 | | 2 | 2 | 4 | |||||||||||||||||||||||
| 12 | | 2 | 3 | 5 | |||||||||||||||||||||||
| 4 | | 2 | 0 | 2 | |||||||||||||||||||||||
| 4 | | 1 | 2 | 3 | |||||||||||||||||||||||
| 13 | | 0 | 2 | 2 | |||||||||||||||||||||||
| 1 | | 2 | 3 | 5 [1] | |||||||||||||||||||||||
| 11 | | 4 | 1 | 5 [3] | |||||||||||||||||||||||
| 6 | | 0 | 2 | 2 | |||||||||||||||||||||||
| 11 | | 2 | 1 | 3 | |||||||||||||||||||||||
| 11 | | 1 | 1 | 2 [5] | |||||||||||||||||||||||
| 14 | | 1 | 1 | 2 [3] | |||||||||||||||||||||||
| 3 | | 1 | 2 | 3 | |||||||||||||||||||||||
| 14 | | 2 | 2 | 4 | |||||||||||||||||||||||
| 11 | | 1 | 0 | 1 | |||||||||||||||||||||||
| 15 | | 1 | 0 | 1 | |||||||||||||||||||||||
| 7 | | 0 | 0 | 0 | |||||||||||||||||||||||
| 10 | | 2 | 2 | 4 | |||||||||||||||||||||||
| 10 | | 0 | 1 | 1 | |||||||||||||||||||||||
| 15 | | 2 | 0 | 2 | |||||||||||||||||||||||
| 2 | | 4 | 0 | 4 | |||||||||||||||||||||||
| 15 | | 2 | 3 | 5 | |||||||||||||||||||||||
The Round of 16 was played between April 29 and 30, and May 1, 6, and 8. [1] Team #1 played the second leg at home.
| Team #1 | Points earned | Team #2 | 1st leg | 2nd leg |
|---|---|---|---|---|
| Fluminense | 6–0 | | 2–1 | 1–0 |
| Flamengo | 3–3 (gd) | | 4–2 | 0–3 |
| River Plate | 1–4 | | 1–2 | 2–2 |
| Atlas | 4–1 | | 1–0 | 2–2 |
| Cruzeiro | 0–6 | | 1–2 | 1–2 |
| Estudiantes | 3–3 (gd) | | 0–2 | 2–1 |
| Cúcuta Deportivo | 0–6 | | 0–2 | 0–2 |
| São Paulo | 4–1 | | 0–0 | 2–0 |
| LDU Quito | 2 – 0 | |
|---|---|---|
| Guerrón Manso | Report [ permanent dead link ] |
| Boca Juniors | 2 – 1 | |
|---|---|---|
| Riquelme Dátolo | Report [ permanent dead link ] | Fabrício |
| América | 2 – 4 | |
|---|---|---|
| Cervantes Esqueda | Report [ permanent dead link ] | Marcinho Tardelli Moura |
| San Lorenzo | 2 – 1 | |
|---|---|---|
| Silvera González | Report [ permanent dead link ] | Falcao |
| Atlético Nacional | 1 – 2 | |
|---|---|---|
| Arrué | Report [ permanent dead link ] | Neves Conca |
| Nacional | 0 – 0 | |
|---|---|---|
| Report [ permanent dead link ] |
| Santos | 2 – 0 | |
|---|---|---|
| Lima Molina | Report [ permanent dead link ] |
| Fluminense | 1 – 0 | |
|---|---|---|
| Roger | Report [ permanent dead link ] |
Fluminense advanced 6–0 on points.
| Estudiantes | 2 – 1 | |
|---|---|---|
| Alayes Maggiolo | Report [ permanent dead link ] | Bolaños |
LDU Quito 3–3 Estudiantes on points. LDU Quito advanced on better goal difference (+1).
| Atlas | 2 – 2 | |
|---|---|---|
| Marioni Mendivil | Report [ permanent dead link ] | Sand Acosta |
Atlas advanced 4–1 on points.
| Cruzeiro | 1 – 2 | |
|---|---|---|
| Wágner | Report [ permanent dead link ] | Palacio Palermo |
Boca Juniors advanced 6–0 on points.
| Flamengo | 0 – 3 | |
|---|---|---|
| Report [ permanent dead link ] | Cabañas Esqueda |
América 3–3 Flamengo on points. América advanced on better goal difference (+1).
| São Paulo | 2 – 0 | |
|---|---|---|
| Adriano Dagoberto | Report [ permanent dead link ] |
São Paulo advanced 4–1 on points.
| River Plate | 2 – 2 | |
|---|---|---|
| Abelairas Abreu | Report [ permanent dead link ] | Bergessio |
San Lorenzo advanced 4–1 on points.
| Cúcuta Deportivo | 0 – 2 | |
|---|---|---|
| Report [ permanent dead link ] | Kléber Pereira Lima |
Santos advanced 6–0 on points.
The Quarterfinals were played on May 14, 15, and May 21 and 22. [1] Team #1 played the second leg at home.
| Team #1 | Points earned | Team #2 | 1st leg | 2nd leg |
|---|---|---|---|---|
| Fluminense | (gd) 3–3 | | 0–1 | 3–1 |
| Santos | 3–3 (gd) | | 0–2 | 1–0 |
| LDU Quito | 2–2 (5–3 p) | | 1–1 | 1–1 |
| Atlas | 1–4 | | 2–2 | 0–3 |
| Boca Juniors | 2 – 2 | |
|---|---|---|
| Ayala Cáceres | Report [ permanent dead link ] | Flores Torres |
| São Paulo | 1 – 0 | |
|---|---|---|
| Adriano | Report [ permanent dead link ] |
| San Lorenzo | 1 – 1 | |
|---|---|---|
| González | Report [ permanent dead link ] | Bieler |
| Atlas | 0 – 3 | |
|---|---|---|
| Report | Palermo |
Boca Juniors advanced 4–1 on points.
| Fluminense | 3 – 1 | |
|---|---|---|
| Washington Dodô | Report [ permanent dead link ] | Adriano |
Fluminense and São Paulo tied 3–3 on points. Fluminense advanced on goal difference (+1).
| LDU Quito | 1 – 1 | |
|---|---|---|
| Manso | Report [ permanent dead link ] | Bergessio |
| Penalties | ||
| Urrutia Campos Vaca Guerrón Bieler | 5 – 3 | |
LDU Quito and San Lorenzo tied 2–2 on points, and tied 0 on goal difference. LDU Quito advanced 5–3 on penalties.
| Santos | 1 – 0 | |
|---|---|---|
| Pereira | Report [ permanent dead link ] |
América and Santos tied 3–3 on points. América advanced on goal difference (+1).
The Semifinals were played between May 27, 28, and June 3, 4. [1] Team #1 played the second leg at home.
| Team #1 | Points earned | Team #2 | 1st leg | 2nd leg |
|---|---|---|---|---|
| Fluminense | 4–1 | | 2–2 | 3–1 |
| LDU Quito | (a) 2–2 | | 1–1 | 0–0 |
| Boca Juniors | 2 – 2 | |
|---|---|---|
| Riquelme | Report [ permanent dead link ] | Silva Neves |
| LDU Quito | 0 – 0 | |
|---|---|---|
| Report [ permanent dead link ] |
LDU Quito 2–2 América on points. LDU Quito advanced on away goals.
| Fluminense | 3 – 1 | |
|---|---|---|
| Washington Ibarra Dodô | Report [ permanent dead link ] | Palermo |
Fluminense advanced 4–1 on points.
| Team #1 | Points earned | Team #2 | 1st leg | 2nd leg |
|---|---|---|---|---|
| LDU Quito | 3–3 a.e.t. (3–1 p) | | 4–2 | 1–3 |
| LDU Quito | 4 – 2 | |
|---|---|---|
| Bieler Guerrón Campos Urrutia | Report [ permanent dead link ] | Conca Neves |