| Singles | |
|---|---|
| 2013 Open Castilla y León | |
| Champion |  Pablo Carreño Busta |
| Runner-up |  Albano Olivetti |
| Score | 6–4, 7–6(7–2) |
Evgeny Donskoy was the defending champion, but chose to participate at the 2013 Odlum Brown Vancouver Open instead.
Pablo Carreño Busta won the title, defeating Albano Olivetti in the final, 6–4, 7–6(7–2).
Pablo Carreño Busta (champion)
Marius Copil (second round)
Andrey Golubev (second round)
Flavio Cipolla (first round)
Marco Chiudinelli (semifinals)
Uladzimir Ignatik (first round) Florent Serra (quarterfinals) Pierre-Hugues Herbert (second round)| Semifinals | Final | ||||||||||||
| 1 | Pablo Carreño Busta | 7 | 6 | ||||||||||
| 5 | Marco Chiudinelli | 5 | 4 | ||||||||||
| 1 | Pablo Carreño Busta | 6 | 77 | ||||||||||
| PR | Albano Olivetti | 4 | 62 | ||||||||||
| WC | Roberto Ortega-Olmedo | 3 | 6 | 610 | |||||||||
| PR | Albano Olivetti | 6 | 3 | 712 | |||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | P Carreño Busta | 77 | 6 | ||||||||||||||||||||||||
 A Jakupovic | 61 | 3 | 1 | P Carreño Busta | 6 | 77 | |||||||||||||||||||||
| A Brugués-Davi | 6 | 4 | 63 |  A Ward | 1 | 63 | |||||||||||||||||||||
| A Ward | 4 | 6 | 77 | 1 | P Carreño Busta | 6 | 6 | ||||||||||||||||||||
| A Artuñedo Martínavarr | 1r | 7 | F Serra | 3 | 1 | ||||||||||||||||||||||
| J Checa Calvo | 2 | J Checa Calvo | 2 | 0 | |||||||||||||||||||||||
| R Carballés Baena | 6 | 3 | 4 | 7 | F Serra | 6 | 6 | ||||||||||||||||||||
| 7 | F Serra | 4 | 6 | 6 | 1 | P Carreño Busta | 7 | 6 | |||||||||||||||||||
| 4 | F Cipolla | 65 | 4 | 5 | M Chiudinelli | 5 | 4 | ||||||||||||||||||||
| Q | Erik Crepaldi | 77 | 6 | Q | E Crepaldi | 3 | 2 | ||||||||||||||||||||
| T Angelinos | 6 | 6 | T Angelinos | 6 | 6 | ||||||||||||||||||||||
| WC | Iván Arenas-Gualda | 2 | 4 | T Angelinos | 1 | 6 | 5 | ||||||||||||||||||||
| WC | Christian Florentin Voinea | 64 | 1r | 5 | M Chiudinelli | 6 | 3 | 7 | |||||||||||||||||||
 A Lobkov | 77 | 4 | A Lobkov | 1 | 0 | ||||||||||||||||||||||
| F Martin | 5 | 3 | 5 | M Chiudinelli | 6 | 6 | |||||||||||||||||||||
| 5 | M Chiudinelli | 7 | 6 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 6 | U Ignatik | 62 | 65 | ||||||||||||||||||||||||
| M Teixeira | 77 | 77 | M Teixeira | 77 | 1 | 1 | |||||||||||||||||||||
| WC | R Ortega-Olmedo | 6 | 6 | WC | R Ortega-Olmedo | 61 | 6 | 6 | |||||||||||||||||||
| M Elgin | 4 | 1 | WC | R Ortega-Olmedo | 77 | 6 | |||||||||||||||||||||
| G Granollers | 7 | 4 | 6 | G Granollers | 65 | 3 | |||||||||||||||||||||
 M Middelkoop | 5 | 6 | 3 | G Granollers | 64 | 6 | 77 | ||||||||||||||||||||
| E López-Pérez | 3 | 5 | 3 | A Golubev | 7 | 3 | 65 | ||||||||||||||||||||
| 3 | A Golubev | 6 | 7 | WC | R Ortega-Olmedo | 3 | 6 | 610 | |||||||||||||||||||
| 8 | P-H Herbert | 6 | 6 | PR | A Olivetti | 6 | 3 | 712 | |||||||||||||||||||
 T Alves | 3 | 2 | 8 | P-H Herbert | 67 | 4 | |||||||||||||||||||||
| Alt | I Navarro | 3 | 64 | PR | A Olivetti | 79 | 6 | ||||||||||||||||||||
| PR | A Olivetti | 6 | 77 | PR | A Olivetti | 7 | 6 | ||||||||||||||||||||
| Q | D Rice | 64 | 0 |  M Fucsovics | 5 | 4 | |||||||||||||||||||||
| M Fucsovics | 77 | 6 | M Fucsovics | 6 | 6 | ||||||||||||||||||||||
| WC | Ricardo Villacorta-Alonso | 2 | 3 | 2 | M Copil | 4 | 4 | ||||||||||||||||||||
| 2 | M Copil | 6 | 6 | ||||||||||||||||||||||||
Pablo Andújar was the two-time defending champion but lost in the first round to fellow countryman Pablo Carreño Busta.
Tommy Robredo won the title, defeating Kevin Anderson in the final, 7–6(8–6), 4–6, 6–3.
Paolo Lorenzi was the defending champion, but was defeated in the semifinals by Pablo Carreño Busta.
David Ferrer was the defending champion, but lost to Mikhail Youzhny in the final, 3–6, 5–7.
Martin Kližan and Philipp Oswald were the defending champions, but Kližan chose not to participate this year. Oswald played alongside Guillermo Durán, but lost in the first round to Rogério Dutra Silva and João Souza.
Juan Sebastián Cabal and Robert Farah won the title, defeating Pablo Carreño Busta and David Marrero in the final, 7–6(7–5), 6–1.
Richard Gasquet was the defending champion, but chose not to participate this year.
Kevin Anderson was the defending champion, but lost in the second round to Jiří Veselý.
This was the first edition of the tournament. Raven Klaasen and Rajeev Ram won the title, defeating Pablo Carreño Busta and Mariusz Fyrstenberg in the final, 7−6(7-2), 7−5.
Marin Čilić was the two-time defending champion, but chose not to participate this year.
Pablo Cuevas was the defending champion, but lost in the first round to Arthur De Greef.
Juan Sebastián Cabal and Robert Farah were the defending champions, but lost in the final to Pablo Carreño Busta and Pablo Cuevas, 4–6, 7–5, [8–10].
Nicolás Almagro was the defending champion, but lost in the quarterfinals to Pablo Carreño Busta.
Pablo Carreño Busta was the defending champion, but lost to Daniil Medvedev in the second round.
Łukasz Kubot and Marcelo Melo were the two time defending champions, but lost in the quarterfinals to Rohan Bopanna and Pablo Cuevas.
Pablo Carreño Busta was the defending champion, but lost in the semifinals to Frances Tiafoe.
Fabio Fognini was the defending champion, but he chose to compete in Umag instead.
Bernard Tomic was the defending champion, but retired in the first round of the qualifying tournament against Denis Istomin.
Ivan Dodig and Filip Polášek were the defending champions but lost in the first round to Pablo Carreño Busta and Alex de Minaur.
Pablo Carreño Busta and Alex de Minaur were the defending champions, but Carreño Busta chose not to defend his title and de Minaur played alongside Cameron Norrie instead. They lost in the quarterfinals to Marcel Granollers and Horacio Zeballos.
Jo-Wilfried Tsonga was the reigning champion from when the tournament was last held in 2019, but chose not to participate this year.
Lorenzo Musetti defeated Carlos Alcaraz in the final, 6–4, 6–7(6–8), 6–4 to win the men's singles tennis title at the 2022 Hamburg European Open. It was his maiden ATP Tour title, and he saved two match points en route, in his first round match against Dušan Lajović.