| 2015 Amex-Istanbul Challenger | |
|---|---|
| Date | 14–20 September |
| Edition | 28th |
| Surface | Hard |
| Location | Istanbul, Turkey |
| Champions | |
| Singles | |
 Karen Khachanov | |
| Doubles | |
Andrey Kuznetsov /  Aleksandr Nedovyesov | |
The 2015 Amex-Istanbul Challenger was a professional tennis tournament played on hard courts. It was the 28th edition of the tournament which was part of the 2015 ATP Challenger Tour. It took place in Istanbul, Turkey between 14 and 20 September 2015.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 UKR | Sergiy Stakhovsky | 60 | 1 |
 TUR | Marsel İlhan | 84 | 2 |
 MDA | Radu Albot | 86 | 3 |
| RUS | Andrey Kuznetsov | 90 | 4 |
| KAZ | Aleksandr Nedovyesov | 100 | 5 |
 ESP | Adrián Menéndez Maceiras | 134 | 6 |
 SWE | Elias Ymer | 144 | 7 |
 BIH | Mirza Bašić | 150 | 8 |
The following players received wildcards into the singles main draw:
Barış Ergüden Sergiy Stakhovsky Barkın Yalçınkale Anıl Yüksel The following players received entry from the qualifying draw:
The following players received entry as a lucky loser:
Karen Khachanov def. Sergiy Stakhovsky 4–6, 6–4, 6–3 Andrey Kuznetsov / Aleksandr Nedovyesov def. 
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