| 2015 Knoxville Challenger | |
|---|---|
| Date | 8–15 November |
| Edition | 12th |
| Surface | Hard |
| Location | Knoxville, United States |
| Champions | |
| Singles | |
 Daniel Evans | |
| Doubles | |
 Johan Brunström /  Frederik Nielsen | |
The 2015 Knoxville Challenger was a professional tennis tournament played on indoor hard courts. It was the twelfth edition of the tournament which was part of the 2015 ATP Challenger Tour. It took place in Knoxville, United States between 8 and 15 November 2015.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 TUN | Malek Jaziri | 95 | 1 |
 USA | Austin Krajicek | 100 | 2 |
| USA | Tim Smyczek | 102 | 3 |
| USA | Ryan Harrison | 110 | 4 |
 AUS | James Duckworth | 116 | 5 |
| AUS | John-Patrick Smith | 122 | 6 |
 COL | Alejandro Falla | 125 | 7 |
 SLO | Blaž Rola | 128 | 8 |
The following players received wildcards into the singles main draw:
Stefan Kozlov Mackenzie McDonald Hunter Reese Luis ValeroThe following players received entry into the singles main draw as special exempts:
The following players received entry from the qualifying draw:
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