| 2016 Knoxville Challenger | |
|---|---|
| Date | 6–13 November |
| Edition | 13th |
| Surface | Hard |
| Location | Knoxville, United States |
| Champions | |
| Singles | |
 Michael Mmoh | |
| Doubles | |
 Peter Polansky / Adil Shamasdin | |
The 2016 Knoxville Challenger was a professional tennis tournament played on indoor hard courts. It was the thirteenth edition of the tournament which was part of the 2016 ATP Challenger Tour. It took place in Knoxville, United States between 6 and 13 November 2016.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 GBR | Daniel Evans | 61 | 1 |
| USA | Frances Tiafoe | 102 | 2 |
| USA | Jared Donaldson | 109 | 3 |
| USA | Bjorn Fratangelo | 110 | 4 |
 AUS | Denis Kudla | 130 | 5 |
| USA | Tim Smyczek | 133 | 6 |
 SUI | Henri Laaksonen | 134 | 7 |
| USA | Stefan Kozlov | 144 | 8 |
The following players received wildcards into the singles main draw:
The following player entered as an alternate:
The following players received entry from the qualifying draw:
Yuki Bhambri Liam Broady Daniel Cox Jared HiltzikThe following player received entry as a lucky loser:
Michael Mmoh def. Peter Polansky, 7–5, 2–6, 6–1. Peter Polansky / Adil Shamasdin def. 
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