Matthew Ebden and Samuel Groth were the defending champions; however, they were defeated 2–6, 6–3, [6–10] by Paolo Lorenzi and Grega Žemlja in the quarterfinals.
Philip Bester and Peter Polansky won the title, defeating Marinko Matosevic and Rubin Jose Statham 6–4, 3–6, [14–12] in the final.
Érik Chvojka and Peter Polansky were the defending champions, but Polansky decided not to participate this year. Chvojka partnered with Lukáš Lacko, but lost in the first round to Philip Bester and Brayden Schnur.
The 2016 Challenger Banque Nationale de Drummondville was a professional tennis tournament played on indoor hard courts. It was the 10th edition of the tournament and part of the 2016 ATP Challenger Tour, offering a total of $50,000 in prize money. It took place in Drummondville, Canada between March 14 and March 20, 2016.
James Cerretani and Antal van der Duim were the defending champions and successfully defended their title, defeating Austin Krajicek and Mitchell Krueger 6–2, 5–7, [10–8] in the final.
Chase Buchanan and Blaž Rola were the defending champions but chose not to defend their title.
Johan Brunström and Frederik Nielsen were the defending champions but chose not to defend their title.
Matteo Donati and Andrey Golubev were the defending champions but only Golubev chose to defend his title, partnering Uladzimir Ignatik. Golubev lost in the first round to Marinko Matosevic and Bradley Mousley.
Philip Bester and Peter Polansky were the defending champions but chose not to defend their title.
James Cerretani and Max Schnur were the defending champions, but decided not to participate this year.
Brian Baker and Ryan Harrison were the defending champions but chose not to defend their title.
Guido Andreozzi and Andrés Molteni were the defending champions but only Andreozzi chose to defend his title, partnering Sergio Galdós. Andreozzi lost in the first round to Alessandro Giannessi and Gianluca Mager.
Martin Kližan and David Marrero were the defending champions, but Kližan chose not to participate this year and Marrero chose to compete in Båstad instead.
Taylor Fritz was the defending champion and successfully defended his title after defeating Brayden Schnur 7–6(9–7), 6–4 in the final.
Jérémy Chardy was the defending champion but chose not to defend his title.
Thanasi Kokkinakis and Matt Reid were the defending champions but only Reid chose to defend his title, partnering Jonny O'Mara. Reid lost in the first round to Egor Gerasimov and Li Zhe.
Tommy Paul was the defending champion but chose not to defend his title.
James Cerretani and Maxime Cressy were the defending champions but chose to compete with different partners. Cerretani partnered Dustin Brown but lost in the semifinals to Lloyd Glasspool and Alex Lawson. Cressy partnered Albano Olivetti but lost in the first round to Marc-Andrea Hüsler and Kamil Majchrzak.
There were no defending champions as the last edition of the tournament was canceled due to the COVID-19 pandemic.
Christian Harrison and Dennis Novikov were the defending champions but lost in the semifinals to William Blumberg and Max Schnur.
Stefan Kozlov and Peter Polansky were the defending champions but withdrew from the tournament due to a Kozlov injury.
James Cerretani 
Daniel Evans 
