| Singles | |
|---|---|
| 2016 Engie Open Métropole 42 | |
| Champion |  Stefanie Vögele |
| Runner-up |  An-Sophie Mestach |
| Final score | 6–1, 6–2 |
Margarita Gasparyan was the defending champion, but chose not to participate.
Stefanie Vögele won the title, defeating An-Sophie Mestach in the final, 6–1, 6–2.
Andreea Mitu (first round) Stefanie Vögele (champion) Romina Oprandi (first round)
Tereza Smitková (quarterfinals)
Çağla Büyükakçay (second round)
Maryna Zanevska (first round)
Océane Dodin (semifinals; retired)
Petra Martić (quarterfinals)| Semifinals | Final | ||||||||||||
| An-Sophie Mestach | 3 | 7 | 77 | ||||||||||
| JE |  Anna Blinkova | 6 | 5 | 65 | |||||||||
| An-Sophie Mestach | 1 | 2 | |||||||||||
| 2 | Stefanie Vögele | 6 | 6 | ||||||||||
| 7 | Océane Dodin | 2r | |||||||||||
| 2 | Stefanie Vögele | 5 | |||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | A Mitu | 2 | 4 | ||||||||||||||||||||||||
| A-S Mestach | 6 | 6 | A-S Mestach | 6 | 6 | ||||||||||||||||||||||
| P Leykina | 6 | 6 | P Leykina | 2 | 4 | ||||||||||||||||||||||
| Q |  D Jakupović | 2 | 2 | A-S Mestach | 6 | 6 | |||||||||||||||||||||
 S Soler Espinosa | 3 | 4 | A Hesse | 2 | 3 | ||||||||||||||||||||||
| A Hesse | 6 | 6 | A Hesse | 6 | 6 | ||||||||||||||||||||||
| V Razzano | 3 | 6 | 6 | V Razzano | 4 | 4 | |||||||||||||||||||||
| 6 | M Zanevska | 6 | 2 | 4 | A-S Mestach | 3 | 7 | 77 | |||||||||||||||||||
| 3 | R Oprandi | 6 | 2 | 4 | JE | A Blinkova | 6 | 5 | 65 | ||||||||||||||||||
| WC | M Georges | 4 | 6 | 6 | WC | M Georges | 6 | 0 | 2 | ||||||||||||||||||
| JE | A Blinkova | 3 | 6 | 7 | JE | A Blinkova | 2 | 6 | 6 | ||||||||||||||||||
| İ Soylu | 6 | 4 | 5 | JE | A Blinkova | 6 | 6 | ||||||||||||||||||||
| T Martincová | 6 | 4 | 4 | 8 | P Martić | 4 | 4 | ||||||||||||||||||||
| Q | E Alexandrova | 2 | 6 | 6 | Q | E Alexandrova | 3 | 3 | |||||||||||||||||||
| S Foretz | 4 | 1 | 8 | P Martić | 6 | 6 | |||||||||||||||||||||
| 8 | P Martić | 6 | 6 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 7 | O Dodin | 7 | 77 | ||||||||||||||||||||||||
| S Sorribes Tormo | 5 | 64 | 7 | O Dodin | 610 | 6 | 7 | ||||||||||||||||||||
| Q |  A Rus | 6 | 6 | Q | A Rus | 712 | 2 | 5 | |||||||||||||||||||
| WC | S Reix | 0 | 4 | 7 | O Dodin | 2 | 6 | 6 | |||||||||||||||||||
| WC | C Roméo | 6 | 6 | 4 | T Smitková | 6 | 2 | 1 | |||||||||||||||||||
| WC | C Touly | 2 | 4 | WC | C Roméo | 63 | 0 | ||||||||||||||||||||
| Q |  A Brianti | 6 | 3 | 69 | 4 | T Smitková | 77 | 6 | |||||||||||||||||||
| 4 | T Smitková | 4 | 6 | 711 | 7 | O Dodin | 2r | ||||||||||||||||||||
| 5 | Ç Büyükakçay | 6 | 6 | 2 | S Vögele | 5 | |||||||||||||||||||||
| A Lim | 2 | 1 | 5 | Ç Büyükakçay | 3 | 3 | |||||||||||||||||||||
| C Burger | 3 | 4 | V Golubic | 6 | 6 | ||||||||||||||||||||||
| V Golubic | 6 | 6 | V Golubic | 2 | 6 | 4 | |||||||||||||||||||||
| L Kerkhove | 6 | 3 | 1 | 2 | S Vögele | 6 | 2 | 6 | |||||||||||||||||||
| A Sadiković | 1 | 6 | 6 | A Sadiković | 1 | 716 | 63 | ||||||||||||||||||||
| E Mertens | 1 | 4 | 2 | S Vögele | 6 | 614 | 77 | ||||||||||||||||||||
| 2 | S Vögele | 6 | 6 | ||||||||||||||||||||||||
Sorana Cîrstea was the defending champion, but she chose to participate at the Hansol Korea Open instead.
Shahar Pe'er won in the final 6-3, 6-4 against Akgul Amanmuradova.
Stefanie Vögele won the first edition of the tournament, defeating Marta Domachowska 6–7(3), 7–5, 6–2 in the final.
Tamarine Tanasugarn was the defending champion, but lost in the semifinals to Stefanie Vögele.
Noppawan Lertcheewakarn was the defending champion, but lost to Stefanie Vögele in the first round.
Victoria Azarenka was the defending champion, but withdrew before her quarterfinal match against Caroline Wozniacki.
Agnieszka Radwańska was the defending champion, but lost 6–0, 6–3 in the semifinals to the eventual champion Serena Williams.
Petra Kvitová was the defending champion, but she was defeated in the final by Simona Halep 6–2, 6–2.
Sara Errani was the two-time defending champion, but chose not to participate.
Dominika Cibulková won the title, defeating Christina McHale in the final, 7–6(7–3), 4–6, 6–4
Karin Knapp was the defending champion but chose not to enter the tournament this year.
Nao Hibino won the title, defeating Donna Vekić in the final, 6–2, 6–2.
Simona Halep was the defending champion, but chose to compete in Brisbane instead.
Anastasia Pavlyuchenkova was the defending champion, but lost in the quarterfinals to Dominika Cibulková.
Misaki Doi was the defending champion, but lost in the first round to Lauren Davis.
Agnieszka Radwańska was the defending champion, but lost in the quarterfinals to Alison Riske.
Roberta Vinci was the defending champion, but lost in the quarterfinals to unseeded Kristina Mladenovic.
Mona Barthel was the defending champion, but lost in the first round to Antonia Lottner.
Anastasija Sevastova was the defending champion, but lost in the final to Tatjana Maria, 4–6, 5–7. This was Maria's first WTA title.
Stefanie Vögele won the title, defeating Sara Sorribes Tormo in the final in straight sets: 6–4, 6–2. Johanna Larsson was the defending champion, but chose not to participate.
Garbiñe Muguruza was the two-time defending champion, but chose not to participate.
Coco Gauff was the defending champion, but chose not to participate this year.
World No. 1 Ashleigh Barty defeated Aryna Sabalenka in the final, 3–6, 6–0, 6–3 to win the women's singles tennis title at the 2021 edition of the Stuttgart Open.