| Singles | |
|---|---|
| 2017 Knoxville Challenger | |
| Champion |  Filip Peliwo |
| Runner-up |  Denis Kudla |
| Final score | 6–4, 6–2 |
Michael Mmoh was the defending champion but lost in the first round to Bradley Klahn.
Filip Peliwo won the title after defeating Denis Kudla 6–4, 6–2 in the final.
Tennys Sandgren (first round)
Henri Laaksonen (semifinals) Taylor Fritz (quarterfinals)
Cameron Norrie (first round) Bjorn Fratangelo (quarterfinals) Stefan Kozlov (first round) Michael Mmoh (first round) Tommy Paul (first round)| Semifinals | Final | ||||||||||||
| PR | Bradley Klahn | 6 | 2 | 5 | |||||||||
| Denis Kudla | 2 | 6 | 7 | ||||||||||
| Denis Kudla | 4 | 2 | |||||||||||
| Q | Filip Peliwo | 6 | 6 | ||||||||||
| Q | Filip Peliwo | 6 | 6 | ||||||||||
| 2 | Henri Laaksonen | 3 | 0 | ||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | T Sandgren | 4 | 65 | ||||||||||||||||||||||||
 J-P Smith | 6 | 77 | J-P Smith | 4 | 7 | 5 | |||||||||||||||||||||
| K King | 2 | 5 | LL | E Corrie | 6 | 5 | 7 | ||||||||||||||||||||
| LL | E Corrie | 6 | 7 | LL | E Corrie | 3 | 63 | ||||||||||||||||||||
| Q |  F Nielsen | 4 | 62 | PR | B Klahn | 6 | 77 | ||||||||||||||||||||
 D King | 6 | 77 | D King | 68 | 5 | ||||||||||||||||||||||
| PR | B Klahn | 1 | 6 | 6 | PR | B Klahn | 710 | 7 | |||||||||||||||||||
| 7 | M Mmoh | 6 | 4 | 4 | PR | B Klahn | 6 | 2 | 5 | ||||||||||||||||||
| 4 | C Norrie | 4 | 6 | 3 | D Kudla | 2 | 6 | 7 | |||||||||||||||||||
| D Kudla | 6 | 3 | 6 | D Kudla | 6 | 6 | |||||||||||||||||||||
| R Opelka | 79 | 4 | 1 | WC | J Hiltzik | 3 | 4 | ||||||||||||||||||||
| WC | Jared Hiltzik | 67 | 6 | 6 | D Kudla | 6 | 3 | 6 | |||||||||||||||||||
| Q |  M Moraing | 6 | 6 | 5 | B Fratangelo | 1 | 6 | 4 | |||||||||||||||||||
| Alt | D Novikov | 4 | 2 | Q | M Moraing | 4 | 7 | 2 | |||||||||||||||||||
| M Krueger | 4 | 5 | 5 | B Fratangelo | 6 | 5 | 6 | ||||||||||||||||||||
| 5 | B Fratangelo | 6 | 7 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 8 | T Paul | 4 | 5 | ||||||||||||||||||||||||
| Q | F Peliwo | 6 | 7 | Q | F Peliwo | 77 | 4 | 6 | |||||||||||||||||||
| WC |  Luis Valero | 0 | 3 | L Broady | 63 | 6 | 4 | ||||||||||||||||||||
| L Broady | 6 | 6 | Q | F Peliwo | 79 | 6 | |||||||||||||||||||||
| D Köpfer | 5 | 3 | 3 | T Fritz | 67 | 1 | |||||||||||||||||||||
| N Rubin | 7 | 6 | N Rubin | 65 | 1 | ||||||||||||||||||||||
| M McDonald | 4 | 3 | 3 | T Fritz | 77 | 6 | |||||||||||||||||||||
| 3 | T Fritz | 6 | 6 | Q | F Peliwo | 6 | 6 | ||||||||||||||||||||
| 6 | S Kozlov | 63 | 2 | 2 | H Laaksonen | 3 | 0 | ||||||||||||||||||||
| T Smyczek | 77 | 6 | T Smyczek | 6 | 6 | ||||||||||||||||||||||
| WC | R Schneider | 3 | 5 | Q | A Ward | 4 | 2 | ||||||||||||||||||||
| Q | A Ward | 6 | 7 | T Smyczek | 61 | 4 | |||||||||||||||||||||
| B Schnur | 6 | 6 | 2 | H Laaksonen | 77 | 6 | |||||||||||||||||||||
| M Giron | 4 | 3 | B Schnur | 4 | 5 | ||||||||||||||||||||||
| WC | Timo Stodder | 4 | 4 | 2 | H Laaksonen | 6 | 7 | ||||||||||||||||||||
| 2 | H Laaksonen | 6 | 6 | ||||||||||||||||||||||||
Nick Kyrgios was the defending champion. However, he did not defend the title after turning 18 and joining the ATP.
Alexander Zverev won the title, defeating Stefan Kozlov in the final, 6–3, 6–0.
Kyle Edmund and Frederico Ferreira Silva were the defending champions, but were not eligible to compete this year.
Borna Ćorić was the defending champion, having won the event in 2013, but elevated to Men's Singles instead as a qualifier.
Benjamin Bonzi and Quentin Halys were the defending champions, but were not eligible to compete this year.
Noah Rubin was the defending champion, but chose not to participate this year.
Lucas Miedler and Bradley Mousley were the defending champions but were no longer eligible to compete in juniors in 2015.
Three-time defending champion Kei Nishikori successfully defended his title, defeating Taylor Fritz in the final, 6–4, 6–4 to win the singles title at the 2016 Memphis Open. Notably, this was only Fritz' third career event on the ATP Tour.
Tim Smyczek was the defending champion but lost in the semifinals to Michael Mmoh.
Roberto Bautista Agut was the defending champion, but withdrew due to a stomach virus.
Ernesto Escobedo was the defending champion but chose not to defend his title.
Frances Tiafoe was the defending champion but chose not to defend his title.
Santiago Giraldo was the defending champion but chose not to defend his title.
Zhang Ze was the defending champion but chose not to defend his title.
Steve Johnson was the defending champion and successfully defended his title, defeating Tennys Sandgren in the final, 7–6(7–2), 2–6, 6–4.
Márton Fucsovics was the defending champion but chose not to defend his title.
This was the first edition of the tournament.
Ante Pavić was the defending champion but chose not to defend his title.
Juan Martín del Potro was the two-time defending champion but chose not to defend his title.
Bradley Klahn was the defending champion but lost in the third round to Michael Mmoh.
Michael Mmoh was the defending champion but lost in the semifinals to Daniel Altmaier.