| Singles | |
|---|---|
| 2018 Aspria Tennis Cup | |
| Champion |  Laslo Đere |
| Runner-up |  Gianluca Mager |
| Score | 6–2, 6–1 |
Guido Pella was the defending champion but chose not to defend his title.
Laslo Đere won the title after defeating Gianluca Mager 6–2, 6–1 in the final.
Laslo Đere (champion)
Pedro Sousa (quarterfinals)
Rogério Dutra Silva (quarterfinals, retired)
Félix Auger-Aliassime (first round)
Carlos Berlocq (first round) Peđa Krstin (semifinals) Gianluigi Quinzi (second round)
Nicola Kuhn (first round)| Semifinals | Final | ||||||||||||
| 1 | Laslo Đere | 78 | 4 | 7 | |||||||||
| SE |  Thiemo de Bakker | 66 | 6 | 5 | |||||||||
| 1 | Laslo Đere | 6 | 6 | ||||||||||
| Q | Gianluca Mager | 2 | 1 | ||||||||||
| 6 | Peđa Krstin | 3 | 1 | ||||||||||
| Q | Gianluca Mager | 6 | 6 | ||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | L Đere | 6 | 5 | 6 | |||||||||||||||||||||||
| Q | J Samper Montaña | 2 | 7 | 1 | 1 | L Đere | 6 | 6 | |||||||||||||||||||
| B Zapata Miralles | 6 | 1 | 6 | B Zapata Miralles | 4 | 3 | |||||||||||||||||||||
| WC | F Baldi | 3 | 6 | 1 | 1 | L Đere | 6 | 6 | |||||||||||||||||||
| L Giustino | 6 | 6 | J Domingues | 4 | 4 | ||||||||||||||||||||||
 M Neuchrist | 3 | 2 | L Giustino | 64 | 2 | ||||||||||||||||||||||
| J Domingues | 66 | 6 | 6 | J Domingues | 77 | 6 | |||||||||||||||||||||
| 5 | C Berlocq | 78 | 3 | 4 | 1 | L Đere | 78 | 4 | 7 | ||||||||||||||||||
| 4 | F Auger-Aliassime | 2 | 1 | SE | T de Bakker | 66 | 6 | 5 | |||||||||||||||||||
| SE | T de Bakker | 6 | 6 | SE | T de Bakker | 6 | 2 | 6 | |||||||||||||||||||
| Q |  A Popyrin | 3 | 4 | M Vilella Martínez | 4 | 6 | 2 | ||||||||||||||||||||
| M Vilella Martínez | 6 | 6 | SE | T de Bakker | 3 | 6 | 6 | ||||||||||||||||||||
| A Arnaboldi | 77 | 6 | A Arnaboldi | 6 | 1 | 4 | |||||||||||||||||||||
| SE | S Griekspoor | 63 | 4 | A Arnaboldi | 7 | 2 | 6 | ||||||||||||||||||||
| H Casanova | 4 | 4 | 7 | G Quinzi | 5 | 6 | 3 | ||||||||||||||||||||
| 7 | G Quinzi | 6 | 6 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 6 | P Krstin | 77 | 6 | ||||||||||||||||||||||||
| P Martínez | 63 | 0 | 6 | P Krstin | 6 | 6 | |||||||||||||||||||||
| Carlos Boluda-Purkiss | 5 | 7 | 1 |  M Bourgue | 4 | 4 | |||||||||||||||||||||
| M Bourgue | 7 | 5 | 6 | 6 | P Krstin | 6 | 3 | ||||||||||||||||||||
| WC | Riccardo Balzerani | 1 | 3 | 3 | R Dutra Silva | 1 | 2r | ||||||||||||||||||||
| Q | H Grenier | 6 | 6 | Q | H Grenier | 4 | 3 | ||||||||||||||||||||
| D Muñoz de la Nava | 4 | 1 | 3 | R Dutra Silva | 6 | 6 | |||||||||||||||||||||
| 3 | R Dutra Silva | 6 | 6 | 6 | P Krstin | 3 | 1 | ||||||||||||||||||||
| 8 | N Kuhn | 2 | 1 | Q | G Mager | 6 | 6 | ||||||||||||||||||||
| Q | G Mager | 6 | 6 | Q | G Mager | 6 | 6 | ||||||||||||||||||||
| WC | A Pellegrino | 2 | 0 | J Monteiro | 1 | 2 | |||||||||||||||||||||
| João Monteiro | 6 | 6 | Q | G Mager | 7 | 7 | |||||||||||||||||||||
| Alt | F Gaio | 6 | 6 | 2 | P Sousa | 5 | 5 | ||||||||||||||||||||
| WC | J Ocleppo | 3 | 0 | Alt | F Gaio | 3 | 4 | ||||||||||||||||||||
| F Argüello | 6 | 4 | 4 | 2 | P Sousa | 6 | 6 | ||||||||||||||||||||
| 2 | P Sousa | 4 | 6 | 6 | |||||||||||||||||||||||
Filip Peliwo was the defending champion, but was no longer eligible to compete in junior tennis, and thus could not defend his title.
Dušan Lajović was the defending champion but chose not to defend his title.
Horacio Zeballos was the defending champion but chose not to defend his title.
Federico Gaio was the defending champion but lost in the second round to Federico Coria.
Robin Haase was the defending champion but chose not to defend his title.
Jan Šátral was the defending champion but chose not to defend his title.
Marco Cecchinato was the defending champion but chose not to defend his title.
Jo-Wilfried Tsonga was the defending champion, but due to injury did not defend his title.
Cedrik-Marcel Stebe was the defending champion but chose not to defend his title.
Roger Federer was the defending champion and successfully defended his title, defeating Marius Copil in the final, 7–6(7–5), 6–4.
Roberto Bautista Agut was the defending champion, but withdrew before the tournament began.
Marco Cecchinato was the defending champion, but withdrew due to illness.
Mischa Zverev was the defending champion, but chose not to participate this year.
Nikoloz Basilashvili was the defending champion and successfully defended his title, defeating Andrey Rublev in the final, 7–5, 4–6, 6–3. En route to doing so, Basilashvili saved two match points against Alexander Zverev in the semifinals.
Juan Ignacio Londero was the defending champion, but lost to Laslo Đere in the quarterfinals.
Laslo Đere was the defending champion, but withdrew with an abdominal injury before the tournament began.
Dominic Thiem was the defending champion and chose not to defend his title, as he was still competing at the 2020 US Open.
Diego Schwartzman defeated Francisco Cerúndolo in the final, 6–1, 6–2 to win the men's singles tennis title at the 2021 Argentina Open.
Lorenzo Sonego defeated defending champion Laslo Đere in the final, 2–6, 7–6(7–5), 6–4 to win the men's singles title at the 2021 Sardegna Open. With the victory, Sonego became the first Italian in 15 years to capture an ATP Tour title on home soil.
John Millman was the defending champion, but lost in the quarterfinals to James Duckworth.