Eugenie Bouchard and Jessica Pegula were the defending champions, having won the event in 2012, but Bouchard chose not to participate in 2013. Pegula partnered up with Emily Harman, but lost in the quarterfinals to Irina Falconi and Maria Sanchez.
Magdaléna Rybáriková was the defending champion, and she successfully defended her title, defeating Andrea Petkovic in the final, 6–4, 7–6(7–2). This was Rybáriková's final WTA singles title before her retirement in 2020.
Teliana Pereira was the defending champion, but lost in the first round to Catalina Pella.
Nao Hibino and Emily Webley-Smith are the defending champions, Hibino chose not to defend her title. Webley-Smith partnered Riko Sawayanagi, but lost in the quarterfinals.
Laura Siegemund was the defending champion, but could not defend her title due to a right knee injury.
Johanna Konta and Maria Sanchez were the defending champions, having won the previous edition in 2015, but Konta chose to participate in Cincinnati instead. Sanchez partnered Sílvia Soler Espinosa, but they lost in the quarterfinals to Emina Bektas and Alexa Guarachi.
Irina Khromacheva and Maryna Zanevska were the defending champions, but Khromacheva chose not to participate. Zanevska partnered Alizé Lim, but they lost in the first round to Audrey Albié and Marine Partaud.
Maryna Zanevska was the defending champion, but chose not to participate.
Lina Gjorcheska and Diāna Marcinkēviča were the defending champions, but Gjorcheska chose not to participate.
Michaëlla Krajicek and Taylor Townsend were the defending champions, but Krajicek chose not to participate. Townsend plays alongside Jessica Pegula, but they withdrew before their quarterfinal match.
This was the first edition of the tournament.
Ashley Weinhold and Caitlin Whoriskey were the defending champions, however both players chose to participate with different partners. Weinhold played alongside Naomi Broady, but lost in the first round to Desirae Krawczyk and Giuliana Olmos. Whoriskey partnered Jacqueline Cako, but they were defeated in the first round by Julia Boserup and Lesley Kerkhove.
Daria Kasatkina was the defending champion, but lost in the quarterfinals to Julia Görges.
The 2018 Space Coast Pro Tennis Classic was a professional tennis tournament played on outdoor clay courts. It was the thirteenth edition of the tournament and was part of the 2018 ITF Women's Circuit. It took place in Indian Harbour Beach, United States, on 9–15 April 2018.
Jovana Jakšić and Catalina Pella were the defending champions, but decided not to participate.
Emina Bektas and Alexa Guarachi were the defending champions, but Bektas chose not to participate.
Kaitlyn Christian and Giuliana Olmos were the defending champions, but Christian chose not to participate. Olmos partnered alongside Kristie Ahn, but lost in the semifinals to Asia Muhammad and Maria Sanchez.
Kaitlyn Christian and Sabrina Santamaria were the defending champions, but chose not to participate.
Jessica Pegula and Taylor Townsend were the defending champions, but both players decided not to participate.
An-Sophie Mestach and Laura Robson were the defending champions, but both players chose not to participate.
Irina Bara 
Sílvia Soler Espinosa 
Jessica Pegula 
