| Singles | |
|---|---|
| 2018 Tiburon Challenger | |
| Champion |  Michael Mmoh |
| Runner-up |  Marcel Granollers |
| Final score | 6–3, 7–5 |
Cameron Norrie was the defending champion but chose not to defend his title.
Michael Mmoh won the title after defeating Marcel Granollers 6–3, 7–5 in the final.
Marcel Granollers (final)
Jordan Thompson (first round)
Peter Polansky (second round)
Henri Laaksonen (first round) Michael Mmoh (champion) Noah Rubin (semifinals) Marc Polmans (first round) Bjorn Fratangelo (second round)| Semifinals | Final | ||||||||||||
| 1 | Marcel Granollers | 6 | 6 | ||||||||||
| 6 | Noah Rubin | 2 | 2 | ||||||||||
| 1 | Marcel Granollers | 3 | 5 | ||||||||||
| 5 | Michael Mmoh | 6 | 7 | ||||||||||
| 5 | Michael Mmoh | 6 | 3 | 6 | |||||||||
| Alt | James Duckworth | 3 | 6 | 3 | |||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | M Granollers | 6 | 7 | ||||||||||||||||||||||||
| E King | 2 | 5 | 1 | M Granollers | 6 | 7 | |||||||||||||||||||||
| Q |  C İlkel | 4 | 6 | 6 | Q | C İlkel | 2 | 5 | |||||||||||||||||||
 L Miedler | 6 | 4 | 3 | 1 | M Granollers | 6 | 6 | ||||||||||||||||||||
| J-P Smith | 6 | 6 | J-P Smith | 2 | 3 | ||||||||||||||||||||||
| P Martínez | 4 | 2 | J-P Smith | 1 | 6 | 6 | |||||||||||||||||||||
 P Krstin | 0 | 3 | 8 | B Fratangelo | 6 | 4 | 2 | ||||||||||||||||||||
| 8 | B Fratangelo | 6 | 6 | 1 | M Granollers | 6 | 6 | ||||||||||||||||||||
| 3 | P Polansky | 6 | 6 | 6 | N Rubin | 2 | 2 | ||||||||||||||||||||
| WC | T Fawcett | 4 | 4 | 3 | P Polansky | 3 | 3 | ||||||||||||||||||||
| C Eubanks | 77 | 77 | C Eubanks | 6 | 6 | ||||||||||||||||||||||
 R Quiroz | 64 | 64 | C Eubanks | 4 | 3 | ||||||||||||||||||||||
 J Clarke | 2 | 65 | 6 | N Rubin | 6 | 6 | |||||||||||||||||||||
| WC | JC Aragone | 6 | 77 | WC | JC Aragone | 63 | 4 | ||||||||||||||||||||
 T de Bakker | 0 | 0 | 6 | N Rubin | 77 | 6 | |||||||||||||||||||||
| 6 | N Rubin | 6 | 6 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 5 | M Mmoh | 6 | 6 | ||||||||||||||||||||||||
 D King | 2 | 4 | 5 | M Mmoh | 6 | 3 | |||||||||||||||||||||
| E Escobedo | 6 | 77 | E Escobedo | 2 | 0r | ||||||||||||||||||||||
| Q | R Ortega Olmedo | 1 | 62 | 5 | M Mmoh | 79 | 2 | 6 | |||||||||||||||||||
| WC | B Holt | 6 | 77 | WC | T Paul | 67 | 6 | 3 | |||||||||||||||||||
| Q | S Diez | 3 | 64 | WC | B Holt | 0r | |||||||||||||||||||||
| WC | T Paul | 6 | 6 | WC | T Paul | 5 | |||||||||||||||||||||
| 4 | H Laaksonen | 4 | 3 | 5 | M Mmoh | 6 | 3 | 6 | |||||||||||||||||||
| 7 | M Polmans | 4 | 4 | Alt | J Duckworth | 3 | 6 | 3 | |||||||||||||||||||
| A Popyrin | 6 | 6 | A Popyrin | 6 | 62 | 66 | |||||||||||||||||||||
| Q | A Sarkissian | 61 | 4 | Alt | J Duckworth | 4 | 77 | 78 | |||||||||||||||||||
| Alt | J Duckworth | 77 | 6 | Alt | J Duckworth | 7 | 6 | ||||||||||||||||||||
| SE |  M Torpegaard | 6 | 6 |  M Arévalo | 5 | 3 | |||||||||||||||||||||
| M Banes | 4 | 2 | SE | M Torpegaard | 3 | 6 | 3 | ||||||||||||||||||||
| M Arévalo | 2 | 77 | 77 | M Arévalo | 6 | 0 | 6 | ||||||||||||||||||||
| 2 | J Thompson | 6 | 62 | 65 | |||||||||||||||||||||||
Bob and Mike Bryan, the two-time defending champions in this event, successfully defended their title. They defeated Mahesh Bhupathi and Leander Paes 6–3, 6–4 in the final.
Andy Murray was the defending champion, but he was eliminated by Juan Mónaco in the second round.
4th seed David Ferrer defeated Lucky loser Marcel Granollers 7–5, 6–3 in the final match.
Marin Čilić was the two-time defending champion; however, he was eliminated by Florian Mayer in the quarterfinals.
Ivan Dodig claimed the first ATP title of his career, by defeating Michael Berrer 6–3, 6–4 in the final match.
Alexandr Dolgopolov was the defending champion but lost in the semifinals to Marin Čilić, who won the title by beating Marcel Granollers 6–4, 6–2 in the final.
John Isner successfully defended his title by beating Tomáš Berdych 3–6, 6–4, 7–6(11–9) in the final.
Robin Haase was the two-time defending champion, but lost in the semifinals to Marcel Granollers. Granollers went on to win the title, defeating Juan Mónaco in the final, 0–6, 7–6(7–3), 6–4.
Bob and Mike Bryan were the defending champions, but lost in the quarterfinals to Marcel Granollers and Marc López.
Leander Paes and Radek Štěpánek were the defending champions, but lost in the third round to Marcel Granollers and Marc López.
Blaž Kavčič was the defending champion but chose not to defend his title.
Michael Mmoh was the defending champion but chose not to defend his title.
Maximilian Marterer was the defending champion but chose not to defend his title.
Ivan Dodig and Marcel Granollers were the defending champions, but chose not to participate together. Dodig was scheduled to play alongside Ben McLachlan, but withdrew with a back injury. Granollers teamed up with Rohan Bopanna, but lost in the quarterfinals to Dominic Inglot and Franko Škugor.
Filip Peliwo was the defending champion but chose not to defend his title.
Bob and Mike Bryan were the defending champions, and successfully defended the title, defeating Wesley Koolhof and Stefanos Tsitsipas in the final, 7–5, 7–6(10–8).
Juan Sebastián Cabal and Robert Farah won their second consecutive Grand Slam men's doubles title, defeating Marcel Granollers and Horacio Zeballos in the final, 6–4, 7–5 to win the men's doubles tennis title at the 2019 US Open. Cabal and Farah retained the ATP no. 1 doubles ranking. Mike Bryan, Łukasz Kubot and Nicolas Mahut were also in contention for the top ranking at the start of the tournament.
Marcel Granollers and Rajeev Ram were the defending champions, but chose to compete with different partners. Granollers played alongside Horacio Zeballos, but lost in the second round to Jamie Murray and Neal Skupski. Ram teamed up with Joe Salisbury, but lost in the quarterfinals to Ivan Dodig and Filip Polášek.
Marcel Granollers and Horacio Zeballos were the defending champions from when the tournament was last held in 2019, but withdrew before the tournament began.
Pablo Carreño Busta and Alex de Minaur were the defending champions, but Carreño Busta chose not to defend his title and de Minaur played alongside Cameron Norrie instead. They lost in the quarterfinals to Marcel Granollers and Horacio Zeballos.
Wesley Koolhof and Neal Skupski defeated Juan Sebastián Cabal and Robert Farah in the final, 6–7(4–7), 6–4, [10–5] to win the men's doubles tennis title at the 2022 Madrid Open. It was their first ATP Masters 1000 title.
Rajeev Ram and Joe Salisbury defeated Tim Pütz and Michael Venus in the final, 7–6(7–4), 7–6(7–5) to win the men's doubles tennis title at the 2022 Cincinnati Masters.