Julian Knowle and Filip Polášek were the defending champions, but Polášek decided not to participate. Knowle played alongside Johan Brunström, but they lost in the quarterfinals to Marcelo Demoliner and Purav Raja.
Andrés Molteni and Fernando Romboli were the defending champions, but both players chose not to participate.
Jérémy Chardy and Łukasz Kubot were the defending champions, but they chose to compete in Hamburg instead.
Łukasz Kubot and Marcelo Melo were the defending champions and successfully defended their title, defeating Oliver Marach and Fabrice Martin in the final, 4–6, 6–3, [13–11].
Bob and Mike Bryan were the defending champions, but chose not to participate this year.
Pierre-Hugues Herbert and Nicolas Mahut were the two-time defending champions, but retired in the first round against Marcus Daniell and Marcelo Demoliner.
Marcelo Arévalo and Miguel Ángel Reyes-Varela were the defending champions but only Arévalo chose to defend his title, partnering Roberto Maytín. Arévalo lost in the first round to Luis David Martínez and David Pérez Sanz.
Sander Arends and Roman Jebavý were the defending champions but only Arends chose to defend his title, partnering Romain Arneodo. Arends lost in the semifinals to Hugo Nys and Jonny O'Mara.
Łukasz Kubot and Marcelo Melo were the two-time defending champions, but lost in the final to Raven Klaasen and Michael Venus, 6–4, 3–6, [4–10].
Marcelo Demoliner and Santiago González were the defending champions, but chose not to participate together. Demoliner played alongside Divij Sharan, but lost in the quarterfinals to Denys Molchanov and Igor Zelenay. González teamed up with Aisam-ul-Haq Qureshi, but lost in the first round to Ivan Dodig and Filip Polášek.
Austin Krajicek and Rajeev Ram were the defending champions, but chose to compete in Stockholm and Antwerp, respectively, instead.
Marcelo Demoliner and Hugo Nys were the defending champions but chose not to defend their title.
Marcelo Demoliner and Matwé Middelkoop were the defending champions, but Middelkoop decide to participate in the 2021 Open Sud de France instead. Demoliner was pairing up with Santiago González, but they lost in the first round to Guillermo Durán and Andrés Molteni.
Hugo Nys and Tim Pütz defeated Luke Bambridge and Dominic Inglot in the final, 7–5, 3–6, [10–3], to win the doubles tennis title at the 2021 Estoril Open. It was Nys and Pütz's first title as a team in their second tournament together on the ATP Tour, marking Nys's second and Pütz's third individual career tour-level doubles titles. Bambridge and Inglot were in contention for their first title as a team after reaching their first tour-level final without dropping a set.
This was the first edition of the tournament, primarily created due to the one-week delay of the 2021 French Open.
Marcelo Demoliner and Matwé Middelkoop were the reigning champions from when the tournament was last held in 2019, but chose to compete with different partners. Demoliner played alongside Marcus Daniell, but lost in the first round to Ariel Behar and Gonzalo Escobar.
Jürgen Melzer and Édouard Roger-Vasselin were the defending champions, but Roger-Vasselin chose not to participate and Melzer chose to compete in Vienna instead.
Ariel Behar and Gonzalo Escobar were the defending champions but chose to play in Rio de Janeiro instead.
Ivan Dodig and Austin Krajicek defeated Máximo González and Marcelo Melo in the final, 6–3, 6–4 to win the doubles tennis title at the 2022 ATP Lyon Open.
Hubert Hurkacz and Mate Pavić defeated Tim Pütz and Michael Venus in the final, 7–6(7–3), 7–6(7–5) to win the doubles tennis title at the 2022 Stuttgart Open.
Marcelo Demoliner 
Hugo Nys 
André Göransson 
Sem Verbeek 
