| Singles | |
|---|---|
| 2019 Lyon Open | |
| Champion |  Benoît Paire |
| Runner-up |  Félix Auger-Aliassime |
| Final score | 6–4, 6–3 |
| Draw | 28 (4 Q / 3 WC ) |
| Seeds | 8 |
Dominic Thiem was the defending champion, but he chose not to defend his title this year.
Benoît Paire won the title, defeating Félix Auger-Aliassime in the final, 6–4, 6–3.
The top four seeds receive a bye into the second round.
Nikoloz Basilashvili (Semifinals)
Roberto Bautista Agut (Quarterfinals) Denis Shapovalov (Quarterfinals) Félix Auger-Aliassime (Final)
Dušan Lajović (First round) Richard Gasquet (Second round, withdrew) Pierre-Hugues Herbert (Second round)
Hubert Hurkacz (First round)| Semifinals | Final | ||||||||||||
| 1 | Nikoloz Basilashvili | 6 | 63 | 4 | |||||||||
| 4 | Félix Auger-Aliassime | 2 | 77 | 6 | |||||||||
| 4 | Félix Auger-Aliassime | 4 | 3 | ||||||||||
| Benoît Paire | 6 | 6 | |||||||||||
| Benoît Paire | 6 | 6 | |||||||||||
 Taylor Fritz | 4 | 2 | |||||||||||
| First Round | Second Round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | N Basilashvili | 7 | 7 | ||||||||||||||||||||||||
| LL | T Lamasine | 6 | 77 | LL | T Lamasine | 5 | 5 | ||||||||||||||||||||
| Q |  J Sinner | 0 | 65 | 1 | N Basilashvili | 6 | 6 | ||||||||||||||||||||
| Q | S Diez | 6 | 4 | PR | J-W Tsonga | 4 | 4 | ||||||||||||||||||||
 B Tomic | 4 | 1r | Q | S Diez | 6 | 62 | 3 | ||||||||||||||||||||
| PR | J-W Tsonga | 77 | 6 | PR | J-W Tsonga | 3 | 77 | 6 | |||||||||||||||||||
| 5 | D Lajović | 64 | 4 | 1 | N Basilashvili | 6 | 63 | 4 | |||||||||||||||||||
| 4 | F Auger-Aliassime | 2 | 77 | 6 | |||||||||||||||||||||||
| 4 | F Auger-Aliassime | 77 | 7 | ||||||||||||||||||||||||
| J Millman | 6 | 6 | J Millman | 63 | 5 | ||||||||||||||||||||||
| P Andújar | 1 | 3 | 4 | F Auger-Aliassime | 6 | 2 | 6 | ||||||||||||||||||||
| S Johnson | 6 | 77 | S Johnson | 4 | 6 | 4 | |||||||||||||||||||||
| LL |  L Harris | 2 | 62 | S Johnson | 78 | 5 | 6 | ||||||||||||||||||||
| J Chardy | 2 | 5 | 7 | P-H Herbert | 66 | 7 | 1 | ||||||||||||||||||||
| 7 | P-H Herbert | 6 | 7 | ||||||||||||||||||||||||
| First Round | Second Round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 8 | H Hurkacz | 4 | 4 | ||||||||||||||||||||||||
 P Cuevas | 6 | 6 | P Cuevas | 4 | 3 | ||||||||||||||||||||||
| B Paire | 3 | 77 | 6 | B Paire | 6 | 6 | |||||||||||||||||||||
| M McDonald | 6 | 65 | 1 | B Paire | 6 | 4 | 77 | ||||||||||||||||||||
| U Humbert | 6 | 6 | 3/WC | D Shapovalov | 3 | 6 | 64 | ||||||||||||||||||||
 C Norrie | 1 | 3 | U Humbert | 6 | 63 | 2 | |||||||||||||||||||||
| 3/WC | D Shapovalov | 2 | 77 | 6 | |||||||||||||||||||||||
| B Paire | 6 | 6 | |||||||||||||||||||||||||
| 6/WC | R Gasquet | 65 | 6 | 77 | T Fritz | 4 | 2 | ||||||||||||||||||||
| Q | M Janvier | 77 | 2 | 62 | 6/WC | R Gasquet | |||||||||||||||||||||
| T Fritz | 7 | 77 | T Fritz | w/o | |||||||||||||||||||||||
| Q |  J Veselý | 5 | 63 | T Fritz | 66 | 6 | 6 | ||||||||||||||||||||
| WC | C Moutet | 6 | 2 | 712 | 2 | R Bautista Agut | 78 | 3 | 4 | ||||||||||||||||||
| R Opelka | 3 | 6 | 610 | WC | C Moutet | 6 | 4 | 3 | |||||||||||||||||||
| 2 | R Bautista Agut | 4 | 6 | 6 | |||||||||||||||||||||||
Lloyd Harris (Qualifying competition, Lucky loser)
Alexander Bublik (First round) Jiří Veselý (Qualified) Alexei Popyrin (First round) Grégoire Barrère (Qualifying competition) Antoine Hoang (First round) Quentin Halys (Qualifying competition) Maxime Janvier (Qualified)| First Round | Qualifying Competition | ||||||||||||
| 1 | Lloyd Harris | 3 | 6 | 6 | |||||||||
| Kenny de Schepper | 6 | 3 | 2 | ||||||||||
| 1 | Lloyd Harris | 1 | 4 | ||||||||||
| 8 | Maxime Janvier | 6 | 6 | ||||||||||
 Guilherme Clezar | 5 | 6 | 4 | ||||||||||
| 8 | Maxime Janvier | 7 | 4 | 6 | |||||||||
| First Round | Qualifying Competition | ||||||||||||
| 2 | Alexander Bublik | 2 | 6 | 5 | |||||||||
| Tristan Lamasine | 6 | 2 | 7 | ||||||||||
| Tristan Lamasine | 4 | 3 | |||||||||||
| WC | Jannik Sinner | 6 | 6 | ||||||||||
| WC | Jannik Sinner | 6 | 5 | 6 | |||||||||
| 6 | Antoine Hoang | 4 | 7 | 1 | |||||||||
| First Round | Qualifying Competition | ||||||||||||
| 3 | Jiří Veselý | 6 | 6 | ||||||||||
| Nicola Kuhn | 4 | 4 | |||||||||||
| 3 | Jiří Veselý | 3 | 6 | 6 | |||||||||
| 5 | Grégoire Barrère | 6 | 3 | 2 | |||||||||
| WC | Hugo Grenier | 77 | 4 | 65 | |||||||||
| 5 | Grégoire Barrère | 63 | 6 | 77 | |||||||||
| First Round | Qualifying Competition | ||||||||||||
| 4 | Alexei Popyrin | 4 | 6 | 5 | |||||||||
| Steven Diez | 6 | 3 | 7 | ||||||||||
| Steven Diez | 6 | 3 | 6 | ||||||||||
| 7 | Quentin Halys | 2 | 6 | 3 | |||||||||
| Mario Vilella Martínez | 62 | 2 | |||||||||||
| 7 | Quentin Halys | 77 | 6 | ||||||||||
Roman Safiullin was the defending champion, but was ineligible to play.
Oliver Anderson won the title, defeating Jurabek Karimov in the final, 6–2, 1–6, 6–1.
Taylor Harry Fritz was the defending champion, but is no longer eligible to compete.
Denis Istomin was the defending champion, but chose not to participate this year.
Jo-Wilfried Tsonga was the defending champion, but lost in the second round to Gaël Monfils.
Diego Schwartzman was the defending champion, but he retired in the first round against Pablo Cuevas.
John Isner was the defending champion but lost to Roger Federer in the final, 1–6, 4–6. It was Federer's 4th Miami title and 28th Masters 1000 title.
Marin Čilić was the defending champion, but lost in the second round to Diego Schwartzman.
Roger Federer was the defending champion, but chose not to participate this year.
Félix Auger-Aliassime was the defending champion but chose not to defend his title.
Alexander Zverev was the two-time defending champion but chose not to defend his title.
Bernard Tomic was the defending champion, but retired in the first round of the qualifying tournament against Denis Istomin.
Kevin Anderson was the defending champion, but could not participate this year due to a knee injury.
Gaël Monfils was the defending champion and successfully defended his title, defeating Félix Auger-Aliassime in the final, 6–2, 6–4.
Stefanos Tsitsipas was the defending champion and successfully defended his title, defeating Félix Auger-Aliassime in the final, 6–3, 6–4.
Nick Kyrgios was the defending champion, but retired from his first round match against Ugo Humbert due to a wrist injury.
Daniil Medvedev was the defending champion, but lost in the quarterfinals to Roberto Bautista Agut.
First seed Alexander Zverev won the tournament, defeating third seed Félix Auger-Aliassime 6–3, 6–3 in the final. This was the first edition of the tournament, primarily organised due to the cancellation of many tournaments in 2020, due to the COVID-19 pandemic.
Daniil Medvedev was the defending champion, but chose not to defend his title.
Alexander Zverev defeated top seed Stefanos Tsitsipas in the final, 6–4, 7–6(7–3) to win the Men's Singles tennis title at the 2021 Mexican Open.
Alexander Zverev defeated Matteo Berrettini in the final, 6–7(8–10), 6–4, 6–3 to win the Men's Singles tennis title at the 2021 Madrid Open.