| Doubles | |
|---|---|
| 2021 Amex-Istanbul Challenger | |
| Champions |  André Göransson  David Pel |
| Runners-up |  Lloyd Glasspool  Harri Heliövaara |
| Final score | 4–6, 6–3, [10–8] |
Ariel Behar and Gonzalo Escobar were the defending champions [1] but chose not to defend their title.
André Göransson and David Pel won the title after defeating Lloyd Glasspool and Harri Heliövaara 4–6, 6–3, [10–8] in the final.
Jonathan Erlich / 
Andrei Vasilevski (semifinals) André Göransson / David Pel (champions)
Nathaniel Lammons / Jackson Withrow (first round) Sander Arends / 
Roman Jebavý (first round)| First round | Quarterfinals | Semifinals | Final | ||||||||||||||||||||||||
| 1 | J Erlich A Vasilevski | 6 | 77 | ||||||||||||||||||||||||
 P Raja R Ramanathan | 1 | 63 | 1 | J Erlich A Vasilevski | 6 | 6 | |||||||||||||||||||||
| WC |  A Çelikbilek C İlkel | 77 | 6 | WC | A Çelikbilek C İlkel | 2 | 3 | ||||||||||||||||||||
| E King N Pasha | 65 | 3 | 1 | J Erlich A Vasilevski | 65 | 3 | |||||||||||||||||||||
| 3 | N Lammons J Withrow | 61 | 4 | L Glasspool H Heliövaara | 77 | 6 | |||||||||||||||||||||
| L Glasspool H Heliövaara | 77 | 6 | L Glasspool H Heliövaara | 6 | 6 | ||||||||||||||||||||||
 LD Martínez  D Vega Hernández | 3 | 77 | [8] | Z Kolář  S Walków | 4 | 3 | |||||||||||||||||||||
| Z Kolář S Walków | 6 | 63 | [10] | L Glasspool H Heliövaara | 6 | 3 | [8] | ||||||||||||||||||||
| WC | S Ağabigün E Kırkın | 3 | 77 | [10] | 2 | A Göransson D Pel | 4 | 6 | [10] | ||||||||||||||||||
| R Galloway A Lawson | 6 | 65 | [12] | R Galloway A Lawson | 6 | 65 | [10] | ||||||||||||||||||||
 DE Galán  E Gómez | 7 | 7 | DE Galán E Gómez | 3 | 77 | [6] | |||||||||||||||||||||
| 4 | S Arends R Jebavý | 5 | 5 | R Galloway A Lawson | 64 | 1 | |||||||||||||||||||||
 L Margaroli  D Molchanov | 5 | 6 | [6] | 2 | A Göransson D Pel | 77 | 6 | ||||||||||||||||||||
 A Hoang A Olivetti | 7 | 4 | [10] | A Hoang A Olivetti | 77 | 4 | [5] | ||||||||||||||||||||
| WC | M İlhan  M Jaziri | 62 | 5 | 2 | A Göransson D Pel | 65 | 6 | [10] | |||||||||||||||||||
| 2 | A Göransson D Pel | 77 | 7 | ||||||||||||||||||||||||
Roberto Maytín and Fernando Romboli were the defending champions but chose not to defend their title.
Jurij Rodionov and Emil Ruusuvuori were the defending champions but chose not to defend their title.
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Markus Eriksson and André Göransson were the defending champions but only Eriksson chose to defend his title, partnering Tuna Altuna. Eriksson lost in the quarterfinals to Sander Arends and David Pel.
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Leander Paes and Miguel Ángel Reyes-Varela were the defending champions but only Reyes-Varela chose to defend his title, partnering Marcelo Arévalo. Reyes-Varela lost in the semifinals to Orlando Luz and Luis David Martínez.
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Andrey Golubev and Aleksandr Nedovyesov were the defending champions but chose not to defend their title.
Andrey Golubev and Aleksandr Nedovyesov were the defending champions but chose not to defend their title.
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Sander Gillé and Joran Vliegen were the reigning champions from when the tournament was last held in 2019, but chose not to defend their title.
Sander Gillé and Joran Vliegen were the reigning champions from when the tournament was last held in 2019, but chose not to participate this year.
André Göransson and David Pel were the defending champions but chose not to defend their title.