| Singles | |
|---|---|
| 2021 Cary Challenger | |
| Champion |  Mitchell Krueger |
| Runner-up |  Ramkumar Ramanathan |
| Score | 7–6(7–4), 6–2 |
Denis Kudla was the defending champion [1] but chose not to defend his title.
Mitchell Krueger won the title after defeating Ramkumar Ramanathan 7–6(7–4), 6–2 in the final.
Jenson Brooksby (withdrew) Prajnesh Gunneswaran (quarterfinals) Maxime Cressy (second round) Bjorn Fratangelo (first round)
Lukáš Lacko (first round) Mitchell Krueger (champion) Christopher Eubanks (quarterfinals) Ramkumar Ramanathan (final)| Semifinals | Final | ||||||||||||
| 6 | Mitchell Krueger | 6 | 6 | ||||||||||
| WC | Govind Nanda | 3 | 2 | ||||||||||
| 6 | Mitchell Krueger | 77 | 6 | ||||||||||
| 8 | Ramkumar Ramanathan | 64 | 2 | ||||||||||
| Stefan Kozlov | 6 | 3 | 1 | ||||||||||
| 8 | Ramkumar Ramanathan | 1 | 6 | 6 | |||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| Q |  GA Olivieri | 4 | 6 | 7 | |||||||||||||||||||||||
| S Mukund | 6 | 2 | 5 | Q | GA Olivieri | 78 | 6 | ||||||||||||||||||||
 R Cid Subervi | 3 | 7 | 6 | R Cid Subervi | 66 | 0 | |||||||||||||||||||||
| G Villanueva | 6 | 5 | 1 | Q | GA Olivieri | 2 | 6 | 3 | |||||||||||||||||||
| Q |  S Mochizuki | 4 | 78 | 4 | 6 | M Krueger | 6 | 2 | 6 | ||||||||||||||||||
| LL |  A McHugh | 6 | 66 | 6 | LL | A McHugh | 1 | 62 | |||||||||||||||||||
| WC | W Blumberg | 6 | 3 | 64 | 6 | M Krueger | 6 | 77 | |||||||||||||||||||
| 6 | M Krueger | 4 | 6 | 77 | 6 | M Krueger | 6 | 6 | |||||||||||||||||||
| 4 | B Fratangelo | 65 | 6 | 3 | WC | G Nanda | 3 | 2 | |||||||||||||||||||
 B Schnur | 77 | 3 | 6 | B Schnur | 6 | 5 | 5 | ||||||||||||||||||||
 R Quiroz | 2 | 3 | WC | G Nanda | 3 | 7 | 7 | ||||||||||||||||||||
| WC | G Nanda | 6 | 6 | WC | G Nanda | 2 | 77 | 6 | |||||||||||||||||||
| C Harrison | 6 | 6 | C Harrison | 6 | 62 | 3 | |||||||||||||||||||||
| Shuichi Sekiguchi | 4 | 4 | C Harrison | 7 | 6 | ||||||||||||||||||||||
 M Torpegaard | 6 | 6 | M Torpegaard | 5 | 2 | ||||||||||||||||||||||
| 5 | L Lacko | 4 | 2 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 7 | C Eubanks | 7 | 6 | ||||||||||||||||||||||||
 P Chrysochos | 5 | 3 | 7 | C Eubanks | 77 | 7 | |||||||||||||||||||||
| J Sock | 2 | 6 | 6 | J Sock | 64 | 5 | |||||||||||||||||||||
| U Blanch | 6 | 4 | 2 | 7 | C Eubanks | 7 | 1 | 3 | |||||||||||||||||||
| S Kozlov | 4 | 6 | 6 | S Kozlov | 5 | 6 | 6 | ||||||||||||||||||||
| D Young | 6 | 4 | 4 | S Kozlov | 3 | 6 | 6 | ||||||||||||||||||||
| N Rubin | 3 | 65 | 3 | M Cressy | 6 | 3 | 4 | ||||||||||||||||||||
| 3 | M Cressy | 6 | 77 | S Kozlov | 6 | 3 | 1 | ||||||||||||||||||||
| 8 | R Ramanathan | 6 | 5 | 6 | 8 | R Ramanathan | 1 | 6 | 6 | ||||||||||||||||||
| Q | A Kovacevic | 4 | 7 | 4 | 8 | R Ramanathan | 77 | 4 | 6 | ||||||||||||||||||
| PR | J Ward | 61 | 0 | Q | A Galarneau | 64 | 6 | 4 | |||||||||||||||||||
| Q | A Galarneau | 77 | 6 | 8 | R Ramanathan | 3 | 77 | 6 | |||||||||||||||||||
| WC | S Riffice | 63 | 6 | 7 | 2 | P Gunneswaran | 6 | 65 | 4 | ||||||||||||||||||
| T Ito | 77 | 4 | 5 | WC | S Riffice | 2 | 4 | ||||||||||||||||||||
| T-S Kwiatkowski | 3 | 2r | 2 | P Gunneswaran | 6 | 6 | |||||||||||||||||||||
| 2 | P Gunneswaran | 6 | 3 | ||||||||||||||||||||||||
John Millman was the defending champion but chose not to defend his title.
Yoshihito Nishioka was the defending champion but chose not to defend his title.
Darian King was the defending champion but chose not to defend his title.
Grigor Dimitrov defeated Nick Kyrgios in the final, 6–3, 7–5 to win the men's singles tennis title at the 2017 Cincinnati Masters. It was his first Masters 1000 title, and he did not lose a set en route.
Stefan Kozlov was the defending champion but chose not to defend his title.
Sam Querrey was the defending champion, but lost in the first round to Matthew Ebden.
Juan Martín del Potro defeated the defending champion Roger Federer in the final, 6–4, 6–7(8–10), 7–6(7–2) to win the men's singles tennis title at the 2018 Indian Wells Masters. He saved three championship points en route to his maiden ATP Tour Masters 1000 title, following three previous runner-up finishes.
John Isner was the defending champion, but withdrew before the tournament began.
Alexander Zverev was the defending champion and successfully defended his title, defeating Alex de Minaur in the final, 6–2, 6–4.
Evgeny Karlovskiy was the defending champion but lost in the first round to Stefan Kozlov.
Steve Johnson was the defending champion, but lost in the first round to Christopher Eubanks.
Jay Clarke was the defending champion but chose not to defend his title.
Thanasi Kokkinakis was the defending champion but lost in the second round to Egor Gerasimov.
Mitchell Krueger was the defending champion but lost in the third round to Denis Kudla.
Marcos Giron was the defending champion but chose not to defend his title.
Kevin Anderson defeated Jenson Brooksby in the final, 7–6(10–8), 6–4, to win the singles tennis title at the 2021 Hall of Fame Open. It was played on outdoor grass courts and was part of the 250 series of the 2021 ATP Tour. It took place at the International Tennis Hall of Fame in Newport, Rhode Island, United States from 12 to 18 July 2021.
Nick Kyrgios was the reigning champion from when the tournament was last held in 2019, but lost in the first round to Mackenzie McDonald.
Mitchell Krueger was the defending champion and successfully defended his title.
Maxime Cressy defeated Alexander Bublik in the final, 2–6, 6–3, 7–6(7–3) to win the men's singles tennis title at the 2022 Hall of Fame Open. It was his maiden ATP Tour title.
Tommy Paul was the defending champion but chose not to defend his title.