| Doubles | |
|---|---|
| 2021 Cary Challenger | |
| Champions |  Christian Harrison Dennis Novikov |
| Runners-up |  Petros Chrysochos  Michail Pervolarakis |
| Score | 6–3, 6–3 |
Teymuraz Gabashvili and Dennis Novikov were the defending champions [1] but only Novikov chose to defend his title, partnering Christian Harrison. Novikov successfully defended his title.
Harrison and Novikov won the title after defeating Petros Chrysochos and Michail Pervolarakis 6–3, 6–3 in the final.
Christian Harrison / Dennis Novikov (champions) Christopher Eubanks / 
Ruan Roelofse (quarterfinals) Mitchell Krueger / 
Brayden Schnur (quarterfinals, withdrew)
Roberto Cid Subervi / 
Roberto Quiroz (first round)| First round | Quarterfinals | Semifinals | Final | ||||||||||||||||||||||||
| 1 | C Harrison D Novikov | 6 | 7 | ||||||||||||||||||||||||
| U Blanch S Riffice | 6 | 7 | U Blanch S Riffice | 3 | 5 | ||||||||||||||||||||||
 B Arias  G Villanueva | 1 | 5 | 1 | C Harrison D Novikov | 7 | 6 | |||||||||||||||||||||
 L Lacko  R Ramanathan | 5 | 3 | |||||||||||||||||||||||||
| 3 | M Krueger B Schnur | ||||||||||||||||||||||||||
| W Blumberg R Harrison | L Lacko R Ramanathan | w/o | |||||||||||||||||||||||||
| L Lacko R Ramanathan | w/o | 1 | C Harrison D Novikov | 6 | 6 | ||||||||||||||||||||||
 T Ito Shuichi Sekiguchi | P Chrysochos M Pervolarakis | 3 | 3 | ||||||||||||||||||||||||
| WC | Sean Scully Andrew Zhang | w/o | WC | S Scully A Zhang | 4 | 2 | |||||||||||||||||||||
| WC | A Kovacevic B Shelton | 6 | 65 | [10] | WC | A Kovacevic B Shelton | 6 | 6 | |||||||||||||||||||
| 4 | R Cid Subervi R Quiroz | 1 | 77 | [8] | WC | A Kovacevic B Shelton | 4 | 6 | [3] | ||||||||||||||||||
 A McHugh J Ward | P Chrysochos M Pervolarakis | 6 | 1 | [10] | |||||||||||||||||||||||
| P Chrysochos M Pervolarakis | w/o | P Chrysochos M Pervolarakis | 6 | 6 | |||||||||||||||||||||||
| 2 | C Eubanks R Roelofse | 4 | 4 | ||||||||||||||||||||||||
David Ferrer was the defending champion, but lost to Alexandr Dolgopolov in the second round.
Two-time defending champion Novak Djokovic defeated Milos Raonic in the final, 6–2, 6–0 to win the men's singles tennis title at the 2016 Indian Wells Masters. It was his then-record-breaking fifth Indian Wells title, before Roger Federer tied the record the following year.
Nicolas Mahut was the defending champion and successfully defended his title, defeating Gilles Müller in the final, 6–4, 6–4.
Kei Nishikori was the defending champion, but chose not to participate this year.
Second-seeded Gaël Monfils won the title, defeating Ivo Karlović in the final: 5–7, 7–6(8–6), 6–4.
Adrian Mannarino was the defending champion and successfully defended his title, defeating Nikola Milojević 6–3, 7–5 in the final.
Dennis Novikov and Julio Peralta were the defending champions but only Novikov chose to defend his title, partnering Stefan Kozlov. Novikov lost in the quarterfinals to Gonzalo Escobar and Roberto Quiroz.
Nick Kyrgios was the defending champion, but withdrew before the tournament began.
Stefan Kozlov was the defending champion but chose not to defend his title.
Evan King and Denis Kudla were the defending champions but only King chose to defend his title, partnering Christopher Eubanks. King successfully defended his title.
Steve Johnson was the defending champion and successfully defended his title, defeating Tennys Sandgren in the final, 7–6(7–2), 2–6, 6–4.
Jeevan Nedunchezhiyan and Christopher Rungkat were the defending champions but chose not to defend their title.
Dennis Novikov was the defending champion but lost in the third round to Renzo Olivo.
Robert Galloway and Bradley Klahn were the defending champions but chose not to defend their title.
Roberto Maytín and Jackson Withrow were the defending champions but chose to defend their title with different partners. Maytín partnered Robert Galloway but lost in the first round to Filip Peliwo and Roy Smith. Withrow partnered Martin Redlicki and successfully defended his title.
Hans Hach Verdugo and Luke Saville were the defending champions but only Hach Verdugo chose to defend his title, partnering Dennis Novikov. Hach Verdugo lost in the first round to Alex Lawson and Jackson Withrow.
Treat Huey and Nathaniel Lammons were the defending champions but only Huey chose to defend his title, partnering Sem Verbeek. Huey lost in the quarterfinals to Emilio Gómez and Roberto Quiroz.
Diego Hidalgo and Martin Redlicki were the defending champions but chose not to defend their title.
Christian Harrison and Dennis Novikov were the defending champions but lost in the semifinals to William Blumberg and Max Schnur.
Treat Huey and Nathaniel Lammons were the defending champions but chose not to defend their title.
Matt Reid and John-Patrick Smith were the defending champions but chose not to defend their title.