| Singles | |
|---|---|
| 2021 Internazionali di Tennis Città di Perugia | |
| Champion |  Tomás Martín Etcheverry |
| Runner-up |  Vitaliy Sachko |
| Score | 7–5, 6–2 |
Federico Delbonis was the defending champion [1] but chose not to defend his title.
Tomás Martín Etcheverry won the title after defeating Vitaliy Sachko 7–5, 6–2 in the final.
Salvatore Caruso (semifinals)
Andrej Martin (first round) Federico Gaio (first round)
Zhang Zhizhen (second round) Thomas Fabbiano (first round)
Dmitry Popko (first round) Tomás Martín Etcheverry (champion) Renzo Olivo (second round)| Semifinals | Final | ||||||||||||
| 1 | Salvatore Caruso | 5 | 7 | 2 | |||||||||
| 7 | Tomás Martín Etcheverry | 7 | 5 | 6 | |||||||||
| 7 | Tomás Martín Etcheverry | 7 | 6 | ||||||||||
| Vitaliy Sachko | 5 | 2 | |||||||||||
 Nino Serdarušić | 4 | 5 | |||||||||||
| Vitaliy Sachko | 6 | 7 | |||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | S Caruso | 77 | 6 | ||||||||||||||||||||||||
| WC | L Vanni | 65 | 4 | 1 | S Caruso | 6 | 6 | ||||||||||||||||||||
| A Collarini | 6 | 5 | 1 | WC | F Forti | 4 | 4 | ||||||||||||||||||||
| WC | F Forti | 4 | 7 | 6 | 1 | S Caruso | 6 | 3 | 6 | ||||||||||||||||||
| F Baldi | 3 | 3 | WC | F Cobolli | 4 | 6 | 3 | ||||||||||||||||||||
 N Borges | 6 | 5r | F Baldi | 2 | 63 | ||||||||||||||||||||||
| WC | F Cobolli | 2 | 7 | 77 | WC | F Cobolli | 6 | 77 | |||||||||||||||||||
| 6 | D Popko | 6 | 5 | 63 | 1 | S Caruso | 5 | 7 | 2 | ||||||||||||||||||
| 3 | F Gaio | 6 | 3 | 62 | 7 | TM Etcheverry | 7 | 5 | 6 | ||||||||||||||||||
 D Kuzmanov | 2 | 6 | 77 | D Kuzmanov | 4 | 65 | |||||||||||||||||||||
| P Cachin | 4 | 65 | Q |  N Fatić | 6 | 77 | |||||||||||||||||||||
| Q | N Fatić | 6 | 77 | Q | N Fatić | 3 | 1 | ||||||||||||||||||||
 Y Maden | 63 | 1 | 7 | TM Etcheverry | 6 | 6 | |||||||||||||||||||||
 D Stricker | 77 | 6 | D Stricker | 5 | 4 | ||||||||||||||||||||||
| A Arnaboldi | 63 | 2 | 7 | TM Etcheverry | 7 | 6 | |||||||||||||||||||||
| 7 | TM Etcheverry | 77 | 6 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 8 | R Olivo | 65 | 7 | 6 | |||||||||||||||||||||||
| Q | G Zeppieri | 77 | 5 | 2 | 8 | R Olivo | 5 | 5 | |||||||||||||||||||
| Q | T Skatov | 1 | 77 | 6 | Q | T Skatov | 7 | 7 | |||||||||||||||||||
| L Giustino | 6 | 65 | 0 | Q | T Skatov | 78 | 4 | 4 | |||||||||||||||||||
| N Serdarušić | 6 | 6 | N Serdarušić | 66 | 6 | 6 | |||||||||||||||||||||
| A Pellegrino | 3 | 3 | N Serdarušić | 78 | 6 | ||||||||||||||||||||||
| Q | F Passaro | 6 | 3 | 2 | 4 | Zh Zhang | 66 | 4 | |||||||||||||||||||
| 4 | Zh Zhang | 3 | 6 | 6 | N Serdarušić | 4 | 5 | ||||||||||||||||||||
| 5 | T Fabbiano | 1 | 6 | 2 | V Sachko | 6 | 7 | ||||||||||||||||||||
 H Rune | 6 | 4 | 6 | H Rune | 6 | 6 | |||||||||||||||||||||
| L Klein | 6 | 77 | L Klein | 4 | 4 | ||||||||||||||||||||||
| R Bonadio | 1 | 64 | H Rune | 3 | 64 | ||||||||||||||||||||||
| GM Moroni | 2 | V Sachko | 6 | 77 | |||||||||||||||||||||||
 E Furness | 0r | GM Moroni | 5 | 6 | 4 | ||||||||||||||||||||||
| V Sachko | 6 | 3 | 6 | V Sachko | 7 | 4 | 6 | ||||||||||||||||||||
| 2 | A Martin | 3 | 6 | 2 | |||||||||||||||||||||||
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