| Singles | |
|---|---|
| 2021 Open Castilla y León | |
| Champion |  Benjamin Bonzi |
| Runner-up |  Tim van Rijthoven |
| Score | 7–6(12–10), 3–6, 6–4 |
Nicola Kuhn was the defending champion [1] but chose not to defend his title.
Benjamin Bonzi won the title after defeating Tim van Rijthoven 7–6(12–10), 3–6, 6–4 in the final.
Feliciano López (quarterfinals) Benjamin Bonzi (champion) Grégoire Barrère (withdrew)
Marc-Andrea Hüsler (first round)
Frederico Ferreira Silva (first round, retired) Quentin Halys (first round) Mathias Bourgue (quarterfinals)
Altuğ Çelikbilek (quarterfinals) Cem İlkel (second round)| Semifinals | Final | ||||||||||||
| Hugo Grenier | 67 | 2 | |||||||||||
| Tim van Rijthoven | 79 | 6 | |||||||||||
| Tim van Rijthoven | 610 | 6 | 4 | ||||||||||
| 2 | Benjamin Bonzi | 712 | 3 | 6 | |||||||||
| Q |  Nicolas Moreno de Alboran | 3 | 6 | 2 | |||||||||
| 2 | Benjamin Bonzi | 6 | 4 | 6 | |||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | F López | 6 | 77 | ||||||||||||||||||||||||
| WC | N Sánchez Izquierdo | 4 | 62 | 1 | F López | 63 | 6 | 6 | |||||||||||||||||||
| WC | Julio César Porras | 78 | 6 | WC | J César Porras | 77 | 2 | 4 | |||||||||||||||||||
 H Moriya | 66 | 2 | 1 | F López | 66 | 1 | |||||||||||||||||||||
| H Grenier | 6 | 6 | H Grenier | 78 | 6 | ||||||||||||||||||||||
 P Kotov | 4 | 2 | H Grenier | 3 | 6 | 6 | |||||||||||||||||||||
| Q | C Gimeno Valero | 6 | 77 | Q | C Gimeno Valero | 6 | 3 | 2 | |||||||||||||||||||
| 6 | Q Halys | 3 | 63 | H Grenier | 67 | 2 | |||||||||||||||||||||
| 4 | M-A Hüsler | 78 | 64 | 5 | T van Rijthoven | 79 | 6 | ||||||||||||||||||||
| T van Rijthoven | 66 | 77 | 7 | T van Rijthoven | 4 | 6 | 6 | ||||||||||||||||||||
 M Jaziri | 65 | 6 | 6 | M Jaziri | 6 | 3 | 3 | ||||||||||||||||||||
| JC Aragone | 77 | 2 | 1 | T van Rijthoven | 6 | 77 | |||||||||||||||||||||
| WC | A Moro Cañas | 3 | 78 | 6 | 7 | M Bourgue | 4 | 63 | |||||||||||||||||||
| G Oliveira | 6 | 66 | 1 | WC | A Moro Cañas | 4 | 2 | ||||||||||||||||||||
| Alt |  FC Jianu | 3 | 4 | 7 | M Bourgue | 6 | 6 | ||||||||||||||||||||
| 7 | M Bourgue | 6 | 6 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 8 | A Çelikbilek | 6 | 6 | ||||||||||||||||||||||||
| Alt |  J Härteis | 3 | 4 | 8 | A Çelikbilek | 6 | 3 | 6 | |||||||||||||||||||
| I Sijsling | 1 | 3 | T Gabashvili | 3 | 6 | 3 | |||||||||||||||||||||
| T Gabashvili | 6 | 6 | 8 | A Çelikbilek | 4 | 2 | |||||||||||||||||||||
| Q |  L Vanni | 4 | 3 | Q | N Moreno de Alboran | 6 | 6 | ||||||||||||||||||||
| Q | N Moreno de Alboran | 6 | 6 | Q | N Moreno de Alboran | 6 | 6 | ||||||||||||||||||||
| R Ortega Olmedo | 6 | 64 | 4 | 9 | C İlkel | 4 | 0 | ||||||||||||||||||||
| 9 | C İlkel | 3 | 77 | 6 | Q | N Moreno de Alboran | 3 | 6 | 2 | ||||||||||||||||||
| 5 | F Ferreira Silva | 4 | 0r | 2 | B Bonzi | 6 | 4 | 6 | |||||||||||||||||||
| Q |  D Svrčina | 6 | 0 | Q | D Svrčina | 6 | 3 | 6 | |||||||||||||||||||
 R Olivo | 7 | 6 | R Olivo | 4 | 6 | 4 | |||||||||||||||||||||
| A Menéndez Maceiras | 5 | 2 | Q | D Svrčina | 3 | 4 | |||||||||||||||||||||
 M Bašić | 4 | 1 | 2 | B Bonzi | 6 | 6 | |||||||||||||||||||||
| M Viola | 6 | 6 | M Viola | 1 | 2 | ||||||||||||||||||||||
| Alt |  A Andreev | 77 | 4 | 63 | 2 | B Bonzi | 6 | 6 | |||||||||||||||||||
| 2 | B Bonzi | 62 | 6 | 77 | |||||||||||||||||||||||
Kyle Edmund and Frederico Ferreira Silva were the defending champions, but were not eligible to compete this year.
Benjamin Bonzi and Quentin Halys were the defending champions, but were not eligible to compete this year.
Denis Shapovalov was the defending champion but chose not to defend his title.
Ken and Neal Skupski were the defending champions, but lost in the quarterfinals to Benjamin Bonzi and Antoine Hoang.
This was the second edition of the tournament. There was no defending champion as the tournament was canceled at the quarterfinals stage due to the COVID-19 pandemic.
Aslan Karatsev was the defending champion but chose not to defend his title.
Roberto Bautista Agut was the defending champion but chose not to defend his title.
Arthur Rinderknech was the defending champion but lost in the semifinals to Benjamin Bonzi.
Andrey Rublev was the defending champion, but lost in the quarterfinals to Botic van de Zandschulp.
Ruben Bemelmans was the defending champion but lost in the quarterfinals to Zizou Bergs.
Andrey Rublev defeated Félix Auger-Aliassime in the final, 7–5, 7–6(7–4) to win the singles title at the 2022 Open 13 Provence.
Defending champion Stefanos Tsitsipas defeated Alejandro Davidovich Fokina in the final, 6–3, 7–6(7–3) to win the singles tennis title at the 2022 Monte-Carlo Masters. He became the sixth player to win consecutive titles at the Monte-Carlo Masters in the Open Era. The win also earned him his second Masters 1000 title and his eighth career singles title overall.
Benjamin Bonzi was the defending champion but chose not to defend his title.
Carlos Taberner was the defending champion but chose not to defend his title.
Benjamin Bonzi was the defending champion but chose not to defend his title.
Benjamin Bonzi was the defending champion but chose not to defend his title.
Benjamin Bonzi was the defending champion but chose not to defend his title.
Benjamin Bonzi was the defending champion but chose not to defend his title.
Brandon Nakashima was the defending champion but chose not to defend his title.
Ugo Humbert was the defending champion but chose not to defend his title.