| Singles | |
|---|---|
| 2021 Open Città della Disfida | |
| Champion |  Giulio Zeppieri |
| Runner-up | Flavio Cobolli |
| Score | 6–1, 3–6, 6–3 |
Gianluca Mager was the defending champion [1] but chose not to defend his title.
Giulio Zeppieri won the title after defeating Flavio Cobolli 6–1, 3–6, 6–3 in the final.
Andrej Martin (second round)
Juan Manuel Cerúndolo (first round, retired)
Jay Clarke (first round)
Tim van Rijthoven (second round) Matteo Viola (first round) Jack Draper (first round) Riccardo Bonadio (first round)
Tseng Chun-hsin (semifinals)| Semifinals | Final | ||||||||||||
| Thiago Agustín Tirante | 1 | 6 | 5 | ||||||||||
| Flavio Cobolli | 6 | 1 | 7 | ||||||||||
| Flavio Cobolli | 1 | 6 | 3 | ||||||||||
| Giulio Zeppieri | 6 | 3 | 6 | ||||||||||
| 8 | Tseng Chun-hsin | 6 | 2 | 3 | |||||||||
| Giulio Zeppieri | 3 | 6 | 6 | ||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | A Martin | 4 | 6 | 6 | |||||||||||||||||||||||
| WC | J Berrettini | 6 | 2 | 1 | 1 | A Martin | 63 | 2 | |||||||||||||||||||
| TA Tirante | 6 | 4 | 6 | TA Tirante | 77 | 6 | |||||||||||||||||||||
 P Chrysochos | 1 | 6 | 2 | TA Tirante | 6 | 6 | |||||||||||||||||||||
| Alt | F Forti | 2 | 2 | Q |  N Álvarez | 2 | 2 | ||||||||||||||||||||
 R Quiroz | 6 | 6 | R Quiroz | 5 | 4 | ||||||||||||||||||||||
| Q | N Álvarez | 4 | 77 | 7 | Q | N Álvarez | 7 | 6 | |||||||||||||||||||
| 7 | R Bonadio | 6 | 65 | 5 | TA Tirante | 1 | 6 | 5 | |||||||||||||||||||
| 4 | T van Rijthoven | 7 | 6 | F Cobolli | 6 | 1 | 7 | ||||||||||||||||||||
| WC | Emiliano Maggioli | 5 | 4 | 4 | T van Rijthoven | 1 | 2 | ||||||||||||||||||||
 P Kotov | 2 | 6 | 2 | F Cobolli | 6 | 6 | |||||||||||||||||||||
| F Cobolli | 6 | 4 | 6 | F Cobolli | 6 | 6 | |||||||||||||||||||||
| PR |  Jeremy Jahn | 1r |  A Dougaz | 3 | 3 | ||||||||||||||||||||||
 P Krstin | 5 | P Krstin | 2 | 2 | |||||||||||||||||||||||
| A Dougaz | 6 | 6 | A Dougaz | 6 | 6 | ||||||||||||||||||||||
| 6 | J Draper | 3 | 2 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 8 | C-h Tseng | 6 | 0 | ||||||||||||||||||||||||
| Q |  R Harrison | 1 | 0r | 8 | C-h Tseng | 5 | 6 | 6 | |||||||||||||||||||
| WC | L Nardi | 6 | 6 | WC | L Nardi | 7 | 2 | 4 | |||||||||||||||||||
| M Jaziri | 3 | 1 | 8 | C-h Tseng | 6 | 6 | |||||||||||||||||||||
 P Sakamoto | 64 | 63 | Q | A Vavassori | 4 | 4 | |||||||||||||||||||||
 N Mejía | 77 | 77 | N Mejía | 3 | 64 | ||||||||||||||||||||||
| Q | A Vavassori | 6 | 6 | Q | A Vavassori | 6 | 77 | ||||||||||||||||||||
| 3 | J Clarke | 3 | 4 | 8 | C-h Tseng | 6 | 2 | 3 | |||||||||||||||||||
| 5 | M Viola | 2 | 5 | G Zeppieri | 3 | 6 | 6 | ||||||||||||||||||||
| Q | C Rodríguez | 6 | 7 | Q | C Rodríguez | 4 | 4 | ||||||||||||||||||||
| J Ocleppo | 6 | 6 | J Ocleppo | 6 | 6 | ||||||||||||||||||||||
| J Sels | 4 | 3 | J Ocleppo | 7 | 3 | 2 | |||||||||||||||||||||
| G Zeppieri | 7 | 6 | G Zeppieri | 5 | 6 | 6 | |||||||||||||||||||||
 T Skatov | 5 | 0 | G Zeppieri | 6 | 6 | ||||||||||||||||||||||
| A Arnaboldi | 6 | 2 | 5 | A Arnaboldi | 3 | 2 | |||||||||||||||||||||
| 2 | JM Cerúndolo | 1 | 6 | 2r | |||||||||||||||||||||||
Gretchen Magers was the defending champion but lost in the quarterfinals to Sara Gomer.
Camille Benjamin was the defending champion but lost in the semifinals to Terry Phelps.
Jeremy Bates and Jo Durie were the defending champions but lost in the second round to Eddie Edwards and Elna Reinach.
Larisa Savchenko-Neiland and Natasha Zvereva were the two-time defending champions and successfully defended their title by defeating Lise Gregory and Gretchen Magers, 3–6, 6–3, 6–3.
Marco Trungelliti was the defending champion but chose not to defend his title.
Nikoloz Basilashvili was the defending champion and successfully defended his title, defeating Andrey Rublev in the final, 7–5, 4–6, 6–3. En route to doing so, Basilashvili saved two match points against Alexander Zverev in the semifinals.
Stefanos Tsitsipas was the defending champion, but chose not to defend his title.
Laslo Đere was the defending champion, but withdrew with an abdominal injury before the tournament began.
Gigi Fernández and Jana Novotná were the defending champions, but none competed this year.
Tommy Robredo was the defending champion but chose not to defend his title.
Pedro Martínez was the defending champion but chose not to defend his title.
Kamil Majchrzak was the defending champion but chose not to defend his title.
Andrey Rublev was the defending champion, but chose to compete in St. Petersburg instead.
Novak Djokovic defeated the defending champion Daniil Medvedev in the final, 4–6, 6–3, 6–3 to win the singles tennis title at the 2021 Paris Masters. It was his record-extending sixth Paris Masters title and record-breaking 37th ATP Tour Masters 1000 title overall, surpassing Rafael Nadal's tally in the latter category.
Andrey Rublev defeated Félix Auger-Aliassime in the final, 7–5, 7–6(7–4) to win the singles title at the 2022 Open 13 Provence.
Gianluca Mager was the defending champion but chose not to defend his title.
Gastão Elias was the defending champion and successfully defended his title, defeating Nino Serdarušić 6–3, 6–4 in the final.
Sebastián Báez defeated Frances Tiafoe in the final, 6–3, 6–2 to win the singles tennis title at the 2022 Estoril Open. It was his maiden ATP Tour title.
Alessandro Giannessi was the defending champion but chose not to defend his title.
Tomás Martín Etcheverry was the defending champion but chose not to defend his title.