| Singles | |
|---|---|
| 2021 Open Montpellier Méditerranée Métropole Hérault | |
| Champion |  Anhelina Kalinina |
| Runner-up |  Mayar Sherif |
| Final score | 6–2, 6–3 |
Varvara Gracheva was the defending champion [1] but chose to compete at Wimbledon instead.
Anhelina Kalinina won the title, defeating Mayar Sherif in the final, 6–2, 6–3.
Océane Dodin (Quarterfinals) Mayar Sherif (Final) Anhelina Kalinina (Champion) Harmony Tan (Second round, retired)
Maddison Inglis (Second round)
Francesca Di Lorenzo (First round)
Cristina Bucșa (Semifinals) Grace Min (First round)| Semifinals | Final | ||||||||||||
 Zheng Qinwen | 1 | 6 | 2 | ||||||||||
| 3 | Anhelina Kalinina | 6 | 4 | 6 | |||||||||
| 3 | Anhelina Kalinina | 6 | 6 | ||||||||||
| 2 | Mayar Sherif | 2 | 3 | ||||||||||
| 7 | Cristina Bucșa | 3 | 4 | ||||||||||
| 2 | Mayar Sherif | 6 | 6 | ||||||||||
| First Round | Second Round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | O Dodin | 7 | 6 | ||||||||||||||||||||||||
| Q | M Yerolymos | 5 | 2 | 1 | O Dodin | 6 | 2 | 6 | |||||||||||||||||||
| Q |  D Spiteri | 4 | 64 |  I Fetecău | 4 | 6 | 0 | ||||||||||||||||||||
| I Fetecău | 6 | 77 | 1 | O Dodin | 5 | 1 | |||||||||||||||||||||
| Q |  Y Morderger | 7 | 6 | Q Zheng | 7 | 6 | |||||||||||||||||||||
| WC | L Jeanjean | 5 | 4 | Q | Y Morderger | 3 | 2 | ||||||||||||||||||||
| Q Zheng | 6 | 6 | Q Zheng | 6 | 6 | ||||||||||||||||||||||
| 8 | G Min | 4 | 3 | Q Zheng | 1 | 6 | 2 | ||||||||||||||||||||
| 3 | A Kalinina | 6 | 7 | 3 | A Kalinina | 6 | 4 | 6 | |||||||||||||||||||
| JE | D Parry | 1 | 5 | 3 | A Kalinina | 6 | 6 | ||||||||||||||||||||
| Q |  YL Miyazaki | 2 | 6 | 6 | Q | YL Miyazaki | 2 | 2 | |||||||||||||||||||
| SE | E Jacquemot | 6 | 3 | 0 | 3 | A Kalinina | 6 | 6 | |||||||||||||||||||
 D Seguel | 6 | 4 | 0 | M Di Giuseppe | 2 | 3 | |||||||||||||||||||||
| M Di Giuseppe | 4 | 6 | 6 | M Di Giuseppe | 77 | 6 | |||||||||||||||||||||
| PR | Y Yuan | 77 | 3 | 2 | 5 | M Inglis | 63 | 1 | |||||||||||||||||||
| 5 | M Inglis | 65 | 6 | 6 | |||||||||||||||||||||||
| First Round | Second Round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 7 | C Bucșa | 6 | 7 | ||||||||||||||||||||||||
| A Hesse | 4 | 5 | 7 | C Bucșa | 77 | 77 | |||||||||||||||||||||
| E-G Ruse | 6 | 6 | E-G Ruse | 62 | 65 | ||||||||||||||||||||||
| Jia Lu | 4 | 2 | 7 | C Bucșa | 6 | 6 | |||||||||||||||||||||
| J Loeb | 77 | 63 | 4 | Q |  S Nahimana | 1 | 2 | ||||||||||||||||||||
| Q | S Nahimana | 64 | 77 | 6 | Q | S Nahimana | 6 | 1 | |||||||||||||||||||
 U Eikeri | 2 | 1 | 4 | H Tan | 2 | 0r | |||||||||||||||||||||
| 4 | H Tan | 6 | 6 | 7 | C Bucșa | 3 | 4 | ||||||||||||||||||||
| 6 | F Di Lorenzo | 1 | 4 | 2 | M Sherif | 6 | 6 | ||||||||||||||||||||
| T Andrianjafitrimo | 6 | 6 | T Andrianjafitrimo | 2 | 1 | ||||||||||||||||||||||
| Q |  O Selekhmeteva | 6 | 6 | Q | O Selekhmeteva | 6 | 6 | ||||||||||||||||||||
| WC | S Djoubri | 3 | 4 | Q | O Selekhmeteva | 3 | 3 | ||||||||||||||||||||
| Q | V Ivakhnenko | 6 | 6 | 2 | M Sherif | 6 | 6 | ||||||||||||||||||||
| WC | C Monnet | 2 | 4 | Q | V Ivakhnenko | 6 | 2 | 3 | |||||||||||||||||||
| Q | G Maristany | 610 | 4 | 2 | M Sherif | 1 | 6 | 6 | |||||||||||||||||||
| 2 | M Sherif | 712 | 6 | ||||||||||||||||||||||||
Eugenie Bouchard was the defending champion, but was chosen to compete in ladies' singles instead.
Eugenie Bouchard and Taylor Townsend were the defending champions, however Bouchard was no longer eligible to compete in junior tennis and thus could not defend her title. Townsend chose not to defend her title, deciding instead to only compete in singles.
Samantha Crawford was the defending champion having won the 2012 event, but chose not to compete in 2013.
Ana Konjuh was the defending champion, but after having won the 2013 US Open – Girls' Singles, she announced she would no longer take part on the junior tour.
Ana Konjuh and Carol Zhao were the defending champions, but both players chose not to compete in 2014.
Barbora Krejčíková and Kateřina Siniaková were the defending champions, having won the event in 2013, but neither player decided to participate this year.
Ana Konjuh was the defending champion, having won the event in 2013, however she chose not to participate.
Anhelina Kalinina and Elizaveta Kulichkova were the defending champions, but both players chose not to compete in 2015.
Olivia Rogowska was the defending champion, but decided to participate in Granby instead.
Svetlana Kuznetsova was the defending champion, but withdrew from her second round match due to a lower left leg injury.
Anhelina Kalinina was the defending champion, but chose not to participate.
Kristýna Plíšková was the defending champion, but lost in the second round to Kurumi Nara.
Svetlana Kuznetsova was the two-time defending champion, but withdrew before the tournament began.
Madison Brengle was the defending champion but lost in the second round to Mari Osaka.
Bernarda Pera was the defending champion, but chose not to participate.
Ekaterina Makarova was the defending champion, but lost in the first round to Ana Bogdan.
Vera Lapko was the defending champion, but chose to participate in Montreal.
Monika Kilnarová was the defending champion, but lost to Dejana Radanović in the first round.
Caty McNally was the defending champion, but lost in the quarterfinals to Anhelina Kalinina.
Coco Gauff was the defending champion, but chose not to participate this year.