| Doubles | |
|---|---|
| 2021 Open de Oeiras III | |
| Champions |  Hunter Reese  Sem Verbeek |
| Runners-up |  Sadio Doumbia Fabien Reboul |
| Score | 4–6, 6–4, [10–7] |
Nuno Borges and Francisco Cabral were the defending champions [1] but lost in the semifinals to Hunter Reese and Sem Verbeek.
Reese and Verbeek won the title after defeating Sadio Doumbia and Fabien Reboul 4–6, 6–4, [10–7] in the final.
Aisam-ul-Haq Qureshi / 
Matt Reid (first round)
Luis David Martínez / 
David Vega Hernández (first round)
Romain Arneodo / 
Szymon Walków (quarterfinals)
Miguel Ángel Reyes-Varela / 
Fernando Romboli (first round)| First round | Quarterfinals | Semifinals | Final | ||||||||||||||||||||||||
| 1 | A-u-H Qureshi M Reid | 2 | 6 | [13] | |||||||||||||||||||||||
 F Coria  E Gómez | 6 | 2 | [15] | F Coria E Gómez | 66 | 4 | |||||||||||||||||||||
| S Johnson M Schnur | 2 | 7 | [10] | S Johnson M Schnur | 78 | 6 | |||||||||||||||||||||
R Matos  P Sousa | 6 | 5 | [7] | S Johnson M Schnur | 62 | 3 | |||||||||||||||||||||
| 4 | MÁ Reyes-Varela F Romboli | 3 | 4 | S Doumbia F Reboul | 77 | 6 | |||||||||||||||||||||
 R Jebavý J Veselý | 6 | 6 | R Jebavý J Veselý | 2 | 711 | [7] | |||||||||||||||||||||
| S Doumbia F Reboul | 6 | 6 | S Doumbia F Reboul | 6 | 69 | [10] | |||||||||||||||||||||
 H Dellien L Mayer | 4 | 3 | S Doumbia F Reboul | 6 | 4 | [7] | |||||||||||||||||||||
| P Martínez B Zapata Miralles | 3 | 6 | [9] | H Reese S Verbeek | 4 | 6 | [10] | ||||||||||||||||||||
| WC | N Borges F Cabral | 6 | 3 | [11] | WC | N Borges F Cabral | 7 | 6 | |||||||||||||||||||
| WC | G Elias Gonçalo Falcão | 1 | 3 | 3 | R Arneodo S Walków | 5 | 3 | ||||||||||||||||||||
| 3 | R Arneodo S Walków | 6 | 6 | WC | N Borges F Cabral | 4 | 4 | ||||||||||||||||||||
| WC | J Domingues F Ferreira Silva | 6 | 64 | [8] | H Reese S Verbeek | 6 | 6 | ||||||||||||||||||||
G Oliveira  Y Uchiyama | 1 | 77 | [10] | G Oliveira Y Uchiyama | 6 | 5 | [3] | ||||||||||||||||||||
| H Reese S Verbeek | 6 | 7 | H Reese S Verbeek | 2 | 7 | [10] | |||||||||||||||||||||
| 2 | LD Martínez D Vega Hernández | 1 | 5 | ||||||||||||||||||||||||
Marc-Andrea Hüsler and Sem Verbeek were the defending champions but chose not to defend their title.
Alex Lawson and Li Zhe were the defending champions but only Li chose to defend his title, partnering Hugo Nys. Li lost in the final to André Göransson and Sem Verbeek.
Robert Galloway and Roberto Maytín were the defending champions but only Maytín chose to defend his title, partnering Jackson Withrow. Maytín lost in the final to Diego Hidalgo and Martin Redlicki.
Matt Reid and Sergiy Stakhovsky were the defending champions but chose not to defend their title.
Hans Hach Verdugo and Luke Saville were the defending champions but only Hach Verdugo chose to defend his title, partnering Dennis Novikov. Hach Verdugo lost in the first round to Alex Lawson and Jackson Withrow.
Sanchai Ratiwatana and Christopher Rungkat were the defending champions but chose not to defend their title.
Lloyd Harris and Dudi Sela were the defending champions but chose not to defend their title.
Romain Arneodo and Andrei Vasilevski were the defending champions but chose not to defend their title.
Treat Huey and Nathaniel Lammons were the defending champions but only Huey chose to defend his title, partnering Sem Verbeek. Huey lost in the quarterfinals to Emilio Gómez and Roberto Quiroz.
Roberto Maytín and Fernando Romboli were the defending champions but chose not to defend their title.
Hunter Reese and Sem Verbeek were the defending champions but chose not to defend their title.
This was the first edition of the tournament.
Romain Arneodo and Hugo Nys were the reigning champions from when the tournament was last held in 2019, but chose to play in Gstaad instead.
Robin Haase and Matwé Middelkoop defeated Lloyd Harris and Tim Pütz in the final, 4–6, 7–6(7–5), [10–5], to win the doubles tennis title at the 2022 ABN AMRO Rotterdam. It was their fourth career ATP Tour doubles title as a team, and marked Haase's seventh individual doubles title and Middelkoop's 12th. Harris and Pütz were competing in their first event together.
Ruben Bemelmans and Daniel Masur were the defending champions but lost in the first round to Marc-Andrea Hüsler and Dominic Stricker.
Marc Polmans and Sergiy Stakhovsky were the defending champions but chose not to defend their title.
This was the first edition of the tournament.
Nathaniel Lammons and Jackson Withrow were the defending champions but only Withrow chose to defend his title, partnering Denys Molchanov. Withrow lost in the quarterfinals to Andrej Martin and Tristan-Samuel Weissborn.
Victor Vlad Cornea and Franko Škugor were the defending champions but chose not to defend their title.
Hunter Reese and Szymon Walków were the defending champions but only Walków chose to defend his title, partnering Łukasz Kubot. Walków lost in the first round to Lorenzo Giustino and Sumit Nagal.