| Singles | |
|---|---|
| 2022 Cali Open | |
| Champion |  Facundo Mena |
| Runner-up |  Miljan Zekić |
| Final score | 6–2, 7–6(7–3) |
This was the first edition of the tournament. The tournament originated as a quick replacement for the 2022 edition of the Quito Challenger, which was moved to Cali due to political unrest in Quito. [1]
Facundo Mena won the title after defeating Miljan Zekić 6–2, 7–6(7–3) in the final.
Tomás Barrios Vera (second round) Facundo Mena (champion) Juan Pablo Ficovich (second round)
Felipe Meligeni Alves (quarterfinals) Francisco Comesaña (first round, retired)
Gerald Melzer (second round) Gonzalo Lama (first round) Miljan Zekić (final)| Semifinals | Final | ||||||||||||
| 8 | Miljan Zekić | 7 | 6 | ||||||||||
 Nicolás Mejía | 5 | 4 | |||||||||||
| 8 | Miljan Zekić | 2 | 63 | ||||||||||
| 2 | Facundo Mena | 6 | 77 | ||||||||||
 Nicolás Álvarez | 66 | 4 | |||||||||||
| 2 | Facundo Mena | 78 | 6 | ||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1/WC | T Barrios Vera | 6 | 77 | ||||||||||||||||||||||||
| Alt |  M Pervolarakis | 2 | 63 | 1/WC | T Barrios Vera | 6 | 2 | 1 | |||||||||||||||||||
| Q | RA Burruchaga | 6 | 6 | Q | RA Burruchaga | 4 | 6 | 6 | |||||||||||||||||||
| G Villanueva | 1 | 1 | Q | RA Burruchaga | 5 | 2 | |||||||||||||||||||||
| P Krstin | 6 | 6 | 8 | M Zekić | 7 | 6 | |||||||||||||||||||||
| Q |  N Chappell | 2 | 4 | P Krstin | 6 | 68 | 5 | ||||||||||||||||||||
| A Kovacevic | 6 | 4 | 1 | 8 | M Zekić | 4 | 710 | 7 | |||||||||||||||||||
| 8 | M Zekić | 1 | 6 | 6 | 8 | M Zekić | 7 | 6 | |||||||||||||||||||
| 3 | JP Ficovich | 6 | 6 | N Mejía | 5 | 4 | |||||||||||||||||||||
| WC | A Urrea | 3 | 1 | 3 | JP Ficovich | 64 | 4 | ||||||||||||||||||||
| Alt | E Zhu | 2 | 2 | N Mejía | 77 | 6 | |||||||||||||||||||||
| N Mejía | 6 | 6 | N Mejía | 6 | 6 | ||||||||||||||||||||||
| Q | Matías Zukas | 6 | 6 | Q | M Zukas | 1 | 4 | ||||||||||||||||||||
| K Smith | 4 | 2 | Q | M Zukas | 2 | 6 | 6 | ||||||||||||||||||||
| J Menezes | 6 | 6 | J Menezes | 6 | 4 | 2 | |||||||||||||||||||||
| 7 | G Lama | 4 | 2 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 5 | F Comesaña | 5 | 0r | ||||||||||||||||||||||||
 R Quiroz | 7 | 0 | R Quiroz | 6 | 3 | 3 | |||||||||||||||||||||
| N Álvarez | 7 | 77 | N Álvarez | 4 | 6 | 6 | |||||||||||||||||||||
 A Menéndez Maceiras | 5 | 63 | N Álvarez | 64 | 6 | 79 | |||||||||||||||||||||
| Q | Juan Bautista Otegui | 6 | 79 | 4 | F Meligeni Alves | 77 | 4 | 67 | |||||||||||||||||||
 V Durasovic | 3 | 67 | Q | JB Otegui | 6 | 4 | 62 | ||||||||||||||||||||
 M Jaziri | 4 | 0r | 4 | F Meligeni Alves | 2 | 6 | 77 | ||||||||||||||||||||
| 4 | F Meligeni Alves | 6 | 4 | N Álvarez | 66 | 4 | |||||||||||||||||||||
| 6 | G Melzer | 6 | 6 | 2 | F Mena | 78 | 6 | ||||||||||||||||||||
| WC | Mateo Gómez | 0 | 0 | 6 | G Melzer | 4 | 2 | ||||||||||||||||||||
| Q |  Y-s Chung | 6 | 6 | Q | Y-s Chung | 6 | 6 | ||||||||||||||||||||
| Q | M Alves | 4 | 0 | Q | Y-s Chung | 3 | 7 | 64 | |||||||||||||||||||
 N Hardt | 6 | 65 | 3 | 2 | F Mena | 6 | 5 | 77 | |||||||||||||||||||
| Facundo Juárez | 4 | 77 | 6 | F Juárez | 4 | 0 | |||||||||||||||||||||
 G Oliveira | 4 | 4 | 2 | F Mena | 6 | 6 | |||||||||||||||||||||
| 2 | F Mena | 6 | 6 | ||||||||||||||||||||||||
Marin Čilić was the defending champion, but withdrew with a knee injury before the tournament began.
Tommy Robredo won the title, defeating Fabio Fognini in the final, 6–0, 6–3.
This was the first edition of the tournament, Laurynas Grigelis and Mohamed Safwat won the title defeating Thiemo de Bakker and Stephan Fransen in the final 6–4, 6–3.
Dominic Thiem was the defending champion and successfully defended his title, defeating Alexander Zverev in the final, 6–4, 3–6, 6–0.
Aljaž Bedene was the two-time defending champion but chose not to participate.
Adrian Ungur was the defending champion but lost in the quarterfinals to Tim Pütz.
Miljan Zekić was the defending champion but lost in the first round to Arthur De Greef.
Fabio Fognini was the defending champion, but lost in the quarterfinals to Andrey Rublev.
Paolo Lorenzi was the defending champion, but lost in the second round to João Sousa.
Aslan Karatsev was the defending champion but chose not to defend his title.
Marcelo Arévalo was the defending champion but chose not to defend his title.
This was the first edition of the tournament as part of the Legión Sudamericana.
Pedro Martínez defeated Sebastián Báez in the final, 4–6, 6–4, 6–4 to win the singles title at the 2022 Chile Open. It was his first ATP Tour title.
This was the first edition of the tournament.
This was the first edition of the tournament.
Giulio Zeppieri was the defending champion but lost in the first round to Matteo Arnaldi.
This was the first edition of the tournament.
The 2022 Cali Open was a professional tennis tournament played on clay courts. It was the first edition of the tournament which was part of the 2022 ATP Challenger Tour. It took place in Cali, Colombia between 27 June and 2 July 2022.
This was the first edition of the tournament. The tournament originated as a quick replacement for the 2022 edition of the Quito Challenger, which was moved to Cali due to political unrest in Quito.
Gerald Melzer was the defending champion but lost in the final to Juan Pablo Ficovich.
This was the first edition of the tournament.