| Doubles | |
|---|---|
| 2022 Challenger de Santiago | |
| Champions |  Diego Hidalgo  Cristian Rodríguez |
| Runners-up |  Pedro Cachin Facundo Mena |
| Score | 6–4, 6–4 |
Evan King and Max Schnur were the defending champions [1] but chose not to defend their title.
Diego Hidalgo and Cristian Rodríguez won the title after defeating Pedro Cachin and Facundo Mena 6–4, 6–4 in the final.
Sergio Galdós / 
Gonçalo Oliveira (first round) Diego Hidalgo / Cristian Rodríguez (champions) Nicolás Barrientos / 
Ruben Gonzales (quarterfinals)
Jesper de Jong / Bart Stevens (semifinals)| First round | Quarterfinals | Semifinals | Final | ||||||||||||||||||||||||
| 1 | S Galdós G Oliveira | 4 | 6 | [7] | |||||||||||||||||||||||
| GA Olivieri C Ugo Carabelli | 6 | 3 | [10] | GA Olivieri C Ugo Carabelli | 6 | 0 | |||||||||||||||||||||
 T Lipovšek Puches JI Londero | 2 | 6 | [10] | T Lipovšek Puches JI Londero | 2 | 0r | |||||||||||||||||||||
 E Furness M Martineau | 6 | 4 | [7] | GA Olivieri C Ugo Carabelli | 4 | 3 | |||||||||||||||||||||
| 3 | N Barrientos R Gonzales | 3 | 6 | [10] | P Cachin F Mena | 6 | 6 | ||||||||||||||||||||
| TM Etcheverry TA Tirante | 6 | 2 | [7] | 3 | N Barrientos R Gonzales | 2 | 77 | [8] | |||||||||||||||||||
| WC |  Daniel Antonio Núñez Sebastián Santibáñez | 3 | 2 | P Cachin F Mena | 6 | 64 | [10] | ||||||||||||||||||||
| P Cachin F Mena | 6 | 6 | P Cachin F Mena | 4 | 4 | ||||||||||||||||||||||
 V Kopřiva A Merino | 2 | 4 | 2 | D Hidalgo C Rodríguez | 6 | 6 | |||||||||||||||||||||
| H Casanova S Rodríguez Taverna | 6 | 6 | H Casanova S Rodríguez Taverna | 6 | 3 | [6] | |||||||||||||||||||||
| A Collarini R Olivo | 5 | 3 | 4 | J de Jong B Stevens | 4 | 6 | [10] | ||||||||||||||||||||
| 4 | J de Jong B Stevens | 7 | 6 | 4 | J de Jong B Stevens | 77 | 4 | [8] | |||||||||||||||||||
 B Arias F Zeballos | 6 | 6 | 2 | D Hidalgo C Rodríguez | 65 | 6 | [10] | ||||||||||||||||||||
| WC | Gonzalo Achondo Benjamín Torres | 2 | 1 | B Arias F Zeballos | 6 | 5 | [5] | ||||||||||||||||||||
| Alt | C Denolly  R Noguchi | 3 | 4 | 2 | D Hidalgo C Rodríguez | 2 | 7 | [10] | |||||||||||||||||||
| 2 | D Hidalgo C Rodríguez | 6 | 6 | ||||||||||||||||||||||||
Luis David Martínez and Felipe Meligeni Alves were the defending champions but only Martínez chose to defend his title, partnering Roberto Quiroz. Martínez lost in the first round to Jesper de Jong and Bart Stevens.
Marin Draganja and Dino Marcan were the reigning champions, but did not defend their title as they had both retired from professional tennis.
Orlando Luz and Rafael Matos were the defending champions but chose not to compete.
This was the first edition of the tournament as part of the Legión Sudamericana.
Martín Cuevas and Paolo Lorenzi were the defending champions but chose not to defend their title.
Orlando Luz and Rafael Matos were the defending champions but chose not to defend their title.
Conner Huertas del Pino and Mats Rosenkranz were the defending champions but only Huertas del Pino chose to defend his title, partnering Alexander Merino. Huertas del Pino lost in the first round to Murkel Dellien and Jorge Panta.
This was the first edition of the tournament.
Vít Kopřiva and Jiří Lehečka were the defending champions but chose not to defend their title.
Orlando Luz and Felipe Meligeni Alves were the defending champions but only Meligeni Alves chose to defend his title, partnering Marcelo Demoliner. Meligeni Alves lost in the quarterfinals to Luciano Darderi and Fernando Romboli.
Orlando Luz and Felipe Meligeni Alves were the defending champions but only Meligeni Alves chose to defend his title, partnering Marcelo Demoliner. Meligeni Alves lost in the quarterfinals to Marco Bortolotti and Sergio Martos Gornés.
Nikola Mektić and Mate Pavić defeated Adrian Mannarino and Fabrice Martin in the final, 6–4, 6–2 to win the doubles tennis title at the 2022 Astana Open.
Diego Hidalgo and Cristian Rodríguez were the defending champions but only Rodríguez chose to defend his title, partnering Luis David Martínez. Rodríguez lost in the first round to Hugo and Murkel Dellien.
Diego Hidalgo and Cristian Rodríguez were the defending champions but lost in the final to Pedro Boscardin Dias and João Lucas Reis da Silva.
Vladyslav Manafov and Oleg Prihodko were the defending champions but chose not to defend their title.
Ruben Gonzales and Reese Stalder were the defending champions but chose not to defend their title.
Boris Arias and Federico Zeballos were the defending champions but lost in the semifinals to Diego Hidalgo and Cristian Rodríguez.
Guido Andreozzi and Guillermo Durán were the defending champions but lost in the semifinals to Fernando Romboli and Marcelo Zormann.
Vasil Kirkov and Matías Soto were the defending champions but chose not to defend their title.
Rubén Ramírez Hidalgo and Pere Riba were the defending champions from when the last tournament was held in 2016 but were unable to defend their title as they had both retired from professional tennis.