| Singles | |
|---|---|
| 2022 Charlottesville Men's Pro Challenger | |
| Champion |  Ben Shelton |
| Runner-up | Christopher Eubanks |
| Final score | 7–6(7–4), 7–5 |
Stefan Kozlov was the defending champion [1] but lost in the second round to Lucas Gerch.
Ben Shelton won the title after defeating Christopher Eubanks 7–6(7–4), 7–5 in the final.
Denis Kudla (quarterfinals) Michael Mmoh (second round) Stefan Kozlov (second round) Christopher Eubanks (final)
Juan Pablo Ficovich (first round) Ben Shelton (champion) Aleksandar Kovacevic (second round) Emilio Nava (semifinals)| Semifinals | Final | ||||||||||||
| 8 | Emilio Nava | 5 | 6 | 3 | |||||||||
| 4 | Christopher Eubanks | 7 | 4 | 6 | |||||||||
| 4 | Christopher Eubanks | 64 | 5 | ||||||||||
| 6 | Ben Shelton | 77 | 7 | ||||||||||
| 6 | Ben Shelton | 78 | 3 | 7 | |||||||||
 Paul Jubb | 66 | 6 | 5 | ||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | D Kudla | 6 | 6 | ||||||||||||||||||||||||
 Sebastian Fanselow | 4 | 3 | 1 | D Kudla | 77 | 1 | 6 | ||||||||||||||||||||
| Q | U Blanch | 6 | 6 | Q | U Blanch | 63 | 6 | 2 | |||||||||||||||||||
 N Mejía | 4 | 4 | 1 | D Kudla | 2 | 1 | |||||||||||||||||||||
| F Mena | 3 | 6 | 710 | 8 | Em Nava | 6 | 6 | ||||||||||||||||||||
| Q | Murphy Cassone | 6 | 3 | 68 | F Mena | 2 | 1 | ||||||||||||||||||||
| Q | Nathan Ponwith | 7 | 2 | 3 | 8 | Em Nava | 6 | 6 | |||||||||||||||||||
| 8 | Em Nava | 5 | 6 | 6 | 8 | Em Nava | 5 | 6 | 3 | ||||||||||||||||||
| 4 | C Eubanks | 6 | 77 | 4 | C Eubanks | 7 | 4 | 6 | |||||||||||||||||||
 N Álvarez Varona | 1 | 63 | 4 | C Eubanks | 7 | 710 | |||||||||||||||||||||
| Alt |  A Dougaz | 3 | 6 | 6 | Alt | A Dougaz | 5 | 68 | |||||||||||||||||||
| Z Svajda | 6 | 2 | 1 | 4 | C Eubanks | 4 | 6 | 710 | |||||||||||||||||||
| Q |  E Leshem | 7 | 6 |  J Shang | 6 | 1 | 68 | ||||||||||||||||||||
 A Galarneau | 5 | 3 | Q | E Leshem | 6 | 3 | 2 | ||||||||||||||||||||
| J Shang | 6 | 3 | 6 | J Shang | 1 | 6 | 6 | ||||||||||||||||||||
| 5 | JP Ficovich | 4 | 6 | 3 | |||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 6 | B Shelton | 6 | 6 | ||||||||||||||||||||||||
| Q |  C Rodesch | 4 | 3 | 6 | B Shelton | 6 | 6 | ||||||||||||||||||||
| B Holt | 6 | 3 | 6 | B Holt | 3 | 4 | |||||||||||||||||||||
| SE | T Sandgren | 1 | 6 | 2 | 6 | B Shelton | 6 | 7 | |||||||||||||||||||
| Alt | Lucas Gerch | 6 | 6 | Alt | L Gerch | 3 | 5 | ||||||||||||||||||||
| WC | E Quinn | 3 | 3 | Alt | L Gerch | 6 | 77 | ||||||||||||||||||||
| M Krueger | 5 | 6 | 61 | 3 | S Kozlov | 4 | 63 | ||||||||||||||||||||
| 3 | S Kozlov | 7 | 0 | 77 | 6 | B Shelton | 78 | 3 | 7 | ||||||||||||||||||
| 7 | A Kovacevic | 6 | 711 | P Jubb | 66 | 6 | 5 | ||||||||||||||||||||
 E Couacaud | 3 | 69 | 7 | A Kovacevic | 64 | 4 | |||||||||||||||||||||
| WC | Alafia Ayeni | 2 | 2 | WC | I Montes de la Torre | 77 | 6 | ||||||||||||||||||||
| WC | I Montes de la Torre | 6 | 6 | WC | I Montes de la Torre | 3 | 2 | ||||||||||||||||||||
| Q | A McHugh | 77 | 3 | 3 | P Jubb | 6 | 6 | ||||||||||||||||||||
| P Jubb | 64 | 6 | 6 | P Jubb | 77 | 6 | |||||||||||||||||||||
| E Escobedo | 65 | 5 | 2 | M Mmoh | 64 | 3 | |||||||||||||||||||||
| 2 | M Mmoh | 77 | 7 | ||||||||||||||||||||||||
Alexander Zverev was the defending champion and successfully defended his title, defeating Alex de Minaur in the final, 6–2, 6–4.
Kevin Anderson was the defending champion, but withdrew before the tournament began because of a right elbow injury.
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Michael Mmoh was the defending champion but lost in the second round to Brandon Nakashima.
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This was the first edition of the tournament.
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Tommy Paul was the defending champion but chose not to defend his title.
Christopher O'Connell was the defending champion but chose not to defend his title.
J. J. Wolf was the defending champion but chose not to defend his title.
Christopher Eubanks is the defending champion.