| Singles | |
|---|---|
| 2022 Columbus Challenger | |
| Champion |  Yoshihito Nishioka |
| Runner-up |  Dominic Stricker |
| Score | 6–2, 6–4 |
Stefan Kozlov was the defending champion [1] but lost in the second round to Dominic Stricker.
Yoshihito Nishioka won the title after defeating Stricker 6–2, 6–4 in the final.
Jenson Brooksby (semifinals) Tennys Sandgren (first round) Yoshihito Nishioka (champion)
Jurij Rodionov (semifinals) Ernesto Escobedo (quarterfinals)
Emilio Gómez (quarterfinals) Jack Sock (quarterfinals, withdrew) Bjorn Fratangelo (second round)| Semifinals | Final | ||||||||||||
| 1/WC | Jenson Brooksby | 3 | 4 | ||||||||||
| 3 | Yoshihito Nishioka | 6 | 6 | ||||||||||
| 3 | Yoshihito Nishioka | 6 | 6 | ||||||||||
| Dominic Stricker | 2 | 4 | |||||||||||
| 4 | Jurij Rodionov | 4 | 6 | 4 | |||||||||
| Dominic Stricker | 6 | 2 | 6 | ||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1/WC | J Brooksby | 2 | 6 | 7 | |||||||||||||||||||||||
| M Krueger | 6 | 3 | 5 | 1/WC | J Brooksby | 7 | 6 | ||||||||||||||||||||
 D Istomin | 7 | 1 | 6 | D Istomin | 5 | 1 | |||||||||||||||||||||
| Q |  S Fanselow | 5 | 6 | 4 | 1/WC | J Brooksby | 6 | 1 | 6 | ||||||||||||||||||
| U Blanch | 79 | 6 | 5 | E Escobedo | 4 | 6 | 1 | ||||||||||||||||||||
| Q | R Quiroz | 67 | 4 | U Blanch | 68 | 4 | |||||||||||||||||||||
 J Jung | 1 | 4 | 5 | E Escobedo | 710 | 6 | |||||||||||||||||||||
| 5 | E Escobedo | 6 | 6 | 1/WC | J Brooksby | 3 | 4 | ||||||||||||||||||||
| 3 | Y Nishioka | 6 | 6 | 3 | Y Nishioka | 6 | 6 | ||||||||||||||||||||
| Q | Yo Watanuki | 4 | 4 | 3 | Y Nishioka | 6 | 2 | 6 | |||||||||||||||||||
| J. J. Wolf | 6 | 6 | J. J. Wolf | 2 | 6 | 4 | |||||||||||||||||||||
| WC | Jack Anthrop | 0 | 3 | 3 | Y Nishioka | 6 | 4 | 6 | |||||||||||||||||||
| Y Uchiyama | 66 | 4 | 6 | E Gómez | 1 | 6 | 3 | ||||||||||||||||||||
| N Kuhn | 78 | 6 | N Kuhn | 66 | 5 | ||||||||||||||||||||||
 G Blancaneaux | 5 | 5 | 6 | E Gómez | 78 | 7 | |||||||||||||||||||||
| 6 | E Gómez | 7 | 7 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 8 | B Fratangelo | 6 | 6 | ||||||||||||||||||||||||
| Q |  N Mejía | 1 | 2 | 8 | B Fratangelo | 1 | 4 | ||||||||||||||||||||
 M Torpegaard | 6 | 77 | M Torpegaard | 6 | 6 | ||||||||||||||||||||||
| M Mmoh | 4 | 63 | M Torpegaard | 77 | 5 | 3r | |||||||||||||||||||||
| Q |  N Hardt | 6 | 77 | 4 | J Rodionov | 61 | 7 | 4 | |||||||||||||||||||
| Q | R Harrison | 4 | 63 | Q | N Hardt | 3 | 2 | ||||||||||||||||||||
 B Schnur | 4 | 7 | 5 | 4 | J Rodionov | 6 | 6 | ||||||||||||||||||||
| 4 | J Rodionov | 6 | 5 | 7 | 4 | J Rodionov | 4 | 6 | 4 | ||||||||||||||||||
| 7 | J Sock | 79 | 64 | 6 | D Stricker | 6 | 2 | 6 | |||||||||||||||||||
| C Eubanks | 67 | 77 | 4 | 7 | J Sock | 6 | 6 | ||||||||||||||||||||
| G Soeda | 77 | 6 | G Soeda | 3 | 4 | ||||||||||||||||||||||
| PR | T-l Wu | 65 | 2 | 7 | J Sock | ||||||||||||||||||||||
| WC | Alexander Bernard | 2 | 1 | D Stricker | w/o | ||||||||||||||||||||||
| S Kozlov | 6 | 6 | S Kozlov | 6 | 4 | 3 | |||||||||||||||||||||
| D Stricker | 6 | 63 | 77 | D Stricker | 4 | 6 | 6 | ||||||||||||||||||||
| 2 | T Sandgren | 4 | 77 | 60 | |||||||||||||||||||||||
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