| Doubles | |
|---|---|
| 2022 Columbus Challenger II | |
| Champions |  Julian Cash Henry Patten |
| Runners-up | Charles Broom  Constantin Frantzen |
| Score | 6–2, 7–5 |
Tennys Sandgren and Mikael Torpegaard were the defending champions [1] but chose not to defend their title.
Julian Cash and Henry Patten won the title after defeating Charles Broom and Constantin Frantzen 6–2, 7–5 in the final.
Julian Cash / Henry Patten (champions)
Nicolás Mejía / 
Roberto Quiroz (first round)
Enzo Couacaud / 
Andrew Harris (quarterfinals)
Benjamin Lock / Courtney John Lock (first round)| First round | Quarterfinals | Semifinals | Final | ||||||||||||||||||||||||
| 1 | J Cash H Patten | 6 | 6 | ||||||||||||||||||||||||
 Jack Anthrop Alexander Bernard | 4 | 2 | A McHugh R Stalder | 2 | 3 | ||||||||||||||||||||||
| A McHugh R Stalder | 6 | 6 | 1 | J Cash H Patten | 6 | 6 | |||||||||||||||||||||
| 3 | E Couacaud A Harris | 6 | 77 | C Kingsley J Tracy | 2 | 2 | |||||||||||||||||||||
| Roy Smith D Young | 4 | 61 | 3 | E Couacaud A Harris | 1 | 4 | |||||||||||||||||||||
| C Kingsley J Tracy | 6 | 6 | |||||||||||||||||||||||||
| 1 | J Cash H Patten | 6 | 7 | ||||||||||||||||||||||||
 J Boulais  J Trotter | 5 | 6 | [10] | C Broom C Frantzen | 2 | 5 | |||||||||||||||||||||
| WC | Preston Stearns Reece Yakubov | 7 | 2 | [4] | J Boulais J Trotter | 77 | 63 | [12] | |||||||||||||||||||
| C Broom C Frantzen | 4 | 6 | [10] | C Broom C Frantzen | 65 | 77 | [14] | ||||||||||||||||||||
| 4 | B Lock CJ Lock | 6 | 3 | [2] | C Broom C Frantzen | 6 | 6 | ||||||||||||||||||||
 D Glinka Karl Kiur Saar | 6 | 7 | WC | R Cash  M Vocel | 4 | 4 | |||||||||||||||||||||
| N Chappell E Zhu | 4 | 5 | D Glinka KK Saar | 1 | 611 | ||||||||||||||||||||||
| WC | R Cash M Vocel | 6 | 6 | WC | R Cash M Vocel | 6 | 713 | ||||||||||||||||||||
| 2 | N Mejía R Quiroz | 3 | 1 | ||||||||||||||||||||||||