| Doubles | |
|---|---|
| 2022 Guanajuato Open | |
| Champions |  Kaitlyn Christian  Lidziya Marozava |
| Runners-up | Anastasia Tikhonova  Daniela Vismane |
| Final score | 6–0, 6–2 |
Paige Hourigan and Astra Sharma were the defending champions having won the previous edition in 2019, [1] however both players chose not to participate.
Kaitlyn Christian and Lidziya Marozava won the title, defeating Anastasia Tikhonova and Daniela Vismane in the final, 6–0, 6–2.
Kaitlyn Christian / Lidziya Marozava (champions)
Valentini Grammatikopoulou / Yana Sizikova (semifinals)
Peangtarn Plipuech / 
Aldila Sutjiadi (first round)
Carolina Alves / Robin Anderson (quarterfinals)| First round | Quarterfinals | Semifinals | Final | ||||||||||||||||||||||||
| 1 | K Christian L Marozava | 6 | 77 | ||||||||||||||||||||||||
| Z Hitt S Schenck | 0 | 4 |  X Han L Zhu | 4 | 64 | ||||||||||||||||||||||
| X Han L Zhu | 6 | 6 | 1 | K Christian L Marozava | 6 | 6 | |||||||||||||||||||||
| 3 | P Plipuech A Sutjiadi | 1 | 2 |  F Contreras  A Hartono | 3 | 2 | |||||||||||||||||||||
| F Contreras A Hartono | 6 | 6 | F Contreras A Hartono | 6 | 6 | ||||||||||||||||||||||
| F Di Lorenzo J Loeb | 6 | 2 | [6] |  L Glushko  R Marino | 2 | 2 | |||||||||||||||||||||
| L Glushko R Marino | 4 | 6 | [10] | 1 | K Christian L Marozava | 6 | 6 | ||||||||||||||||||||
| A Tikhonova D Vismane | 6 | 1 | [12] | A Tikhonova D Vismane | 0 | 2 | |||||||||||||||||||||
| Q Gleason M Zacarías | 1 | 6 | [10] | A Tikhonova D Vismane | 7 | 5 | [10] | ||||||||||||||||||||
| D Hewitt W Osuigwe | 4 | 3 | 4 | C Alves R Anderson | 5 | 7 | [8] | ||||||||||||||||||||
| 4 | C Alves R Anderson | 6 | 6 | A Tikhonova D Vismane | 3 | 6 | [10] | ||||||||||||||||||||
 G Arangio CS Martínez Solís | 1 | 5 | 2 | V Grammatikopoulou Y Sizikova | 6 | 3 | [8] | ||||||||||||||||||||
| J Hinojosa Gómez N Urbina | 6 | 7 | J Hinojosa Gómez N Urbina | 4 | 3 | ||||||||||||||||||||||
 AM Becerra X Negrete Hernández | 2 | 0 | 2 | V Grammatikopoulou Y Sizikova | 6 | 6 | |||||||||||||||||||||
| 2 | V Grammatikopoulou Y Sizikova | 6 | 6 | ||||||||||||||||||||||||
Lyudmyla Kichenok and Nadiia Kichenok were the defending champions, but both players chose not to participate.
Çağla Büyükakçay and Maria Sakkari were the defending champions, but Sakkari chose not to participate. Büyükakçay partnered Mona Barthel, but lost in the quarterfinals to Lesley Kerkhove and Lidziya Marozava.
Ankita Raina and Emily Webley-Smith were the defending champions, but both players chose not to participate.
Eri Hozumi and Miyu Kato were the defending champions, but Kato chose not to participate this year. Hozumi played alongside Asia Muhammad, but lost in the final to sisters Hsieh Shu-ying and Hsieh Su-wei, 1–6, 6–7(3–7).
Chan Hao-ching and Latisha Chan were the defending champions, but Latisha could not participate due to a medical condition. Hao-ching played alongside Yang Zhaoxuan, but they lost in the first round to Nadiia Kichenok and Anastasia Rodionova.
Lesley Kerkhove and Lidziya Marozava were the defending champions, but Kerkhove chose not to participate and Marozava chose to compete in Moscow instead.
Duan Yingying and Han Xinyun were the defending champions, but did not participate this year.
Jiang Xinyu and Tang Qianhui were the two-time defending champions, but lost in the semifinals to Peng Shuai and Zhang Shuai.
Nicoleta Dascălu and Raluca Șerban were the defending champions but chose not to participate.
Shuko Aoyama and Ena Shibahara were the defending champions, but they decided not to participate this year.
This was the first edition of the tournament.
This was the first edition of the tournament.
Paula Kania-Choduń and Katarzyna Piter were the defending champions but chose not to participate.
Andrea Sestini Hlaváčková and Lucie Hradecká were the defending champions having won the previous edition in 2013, but Hradecká chose to compete at the 2021 Prague Open instead, whilst Sestini Hlaváčková retired from professional tennis in 2019.
This was the first edition of the tournament.
This was the first edition of the tournament.
Coco Gauff and Caty McNally were the reigning champions, having won the last edition in 2019, but chose not to defend their title.
Ellen Perez and Astra Sharma were the reigning champions, but Sharma chose not to compete and Perez competed in Doha instead.
Caroline Dolehide and Asia Muhammad were the defending champions, but they chose not to participate.
The 2022 Guanajuato Open was a professional tennis tournament played on outdoor hard courts. It was the fourteenth edition of the tournament which was part of the 2022 ITF Women's World Tennis Tour. It took place in Irapuato, Mexico between 7 and 13 March 2022.