| Singles | |
|---|---|
| 2022 JC Ferrero Challenger Open | |
| Champion |  Lukáš Klein |
| Runner-up |  Nick Hardt |
| Score | 6–3, 6–4 |
Constant Lestienne was the defending champion [1] but chose not to defend his title.
Lukáš Klein won the title after defeating Nick Hardt 6–3, 6–4 in the final.
Fernando Verdasco (second round)
Geoffrey Blancaneaux (first round, retired)
Matteo Arnaldi (semifinals)
Dimitar Kuzmanov (quarterfinals) Raúl Brancaccio (second round)
Emilio Nava (quarterfinals)
Fábián Marozsán (semifinals) Lukáš Klein (champion)| Semifinals | Final | ||||||||||||
| 8 | Lukáš Klein | 6 | 77 | ||||||||||
| 7 | Fábián Marozsán | 4 | 62 | ||||||||||
| 8 | Lukáš Klein | 6 | 6 | ||||||||||
| Nick Hardt | 3 | 4 | |||||||||||
| 3 | Matteo Arnaldi | 7 | 5 | 4 | |||||||||
| Nick Hardt | 5 | 7 | 6 | ||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | F Verdasco | 7 | 4 | 6 | |||||||||||||||||||||||
 J Domingues | 5 | 6 | 0 | 1 | F Verdasco | 4 | 64 | ||||||||||||||||||||
 O Krutykh | 5 | 6 | 3 | S Caruso | 6 | 77 | |||||||||||||||||||||
| S Caruso | 7 | 1 | 6 | S Caruso | 3 | 0 | |||||||||||||||||||||
| WC | M Landaluce | 2 | 3 | 8 | L Klein | 6 | 6 | ||||||||||||||||||||
 M Geerts | 6 | 6 | M Geerts | 6 | 65 | 4 | |||||||||||||||||||||
 K Żuk | 3 | 4 | 8 | L Klein | 4 | 77 | 6 | ||||||||||||||||||||
| 8 | L Klein | 6 | 6 | 8 | L Klein | 6 | 77 | ||||||||||||||||||||
| 4 | D Kuzmanov | 6 | 6 | 7 | F Marozsán | 4 | 62 | ||||||||||||||||||||
| Q |  S Diez | 3 | 2 | 4 | D Kuzmanov | 6 | 6 | ||||||||||||||||||||
| Alt |  B Harris | 6 | 6 | Alt | B Harris | 4 | 4 | ||||||||||||||||||||
| WC | Dali Blanch | 3 | 4 | 4 | D Kuzmanov | 6 | 5 | 5 | |||||||||||||||||||
| Q | S Parker | 6 | 4 | 1 | 7 | F Marozsán | 3 | 7 | 7 | ||||||||||||||||||
| L Giustino | 4 | 6 | 6 | L Giustino | 2 | 6 | 1 | ||||||||||||||||||||
| Q |  H Habib | 2 | 1 | 7 | F Marozsán | 6 | 3 | 6 | |||||||||||||||||||
| 7 | F Marozsán | 6 | 6 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 5 | R Brancaccio | 7 | 7 | ||||||||||||||||||||||||
| Q |  Y Bu | 5 | 5 | 5 | R Brancaccio | 2 | 3 | ||||||||||||||||||||
| F Ferreira Silva | 4 | 6 | 6 | F Ferreira Silva | 6 | 6 | |||||||||||||||||||||
| B Hassan | 6 | 2 | 0 | F Ferreira Silva | 5 | 6 | 4 | ||||||||||||||||||||
 J de Jong | 6 | 6 | 3 | M Arnaldi | 7 | 4 | 6 | ||||||||||||||||||||
| Alt | R Haase | 3 | 1 | J de Jong | 3 | 2 | |||||||||||||||||||||
| WC | U Blanch | 1 | 5 | 3 | M Arnaldi | 6 | 6 | ||||||||||||||||||||
| 3 | M Arnaldi | 6 | 7 | 3 | M Arnaldi | 7 | 5 | 4 | |||||||||||||||||||
| 6 | Em Nava | 6 | 6 | N Hardt | 5 | 7 | 6 | ||||||||||||||||||||
| H Mayot | 3 | 4 | 6 | Em Nava | 6 | 6 | |||||||||||||||||||||
| Q |  R Molleker | 3 | 3 | Q | F Gaio | 3 | 2 | ||||||||||||||||||||
| Q | F Gaio | 6 | 6 | 6 | Em Nava | 77 | 63 | 1 | |||||||||||||||||||
| N Álvarez Varona | 6 | 7 | N Hardt | 65 | 77 | 6 | |||||||||||||||||||||
 G Décamps | 2 | 5 | N Álvarez Varona | 66 | 4 | ||||||||||||||||||||||
| N Hardt | 6 | 1 | N Hardt | 78 | 6 | ||||||||||||||||||||||
| 2 | G Blancaneaux | 2 | 0r | ||||||||||||||||||||||||
Roger Federer was the two-time defending champion and successfully defended his title, defeating Andreas Seppi in the final, 7–6(7–1), 6–4.
Pablo Cuevas was the defending champion. He lost his title in the semifinals to Benoît Paire. Paire went on to win the title, defeating Tommy Robredo in the final, 7–6(9–7), 6–3.
David Goffin was the defending champion but chose not to participate this year.
Jo-Wilfried Tsonga was the defending champion, but withdrew with a left knee injury before the tournament began.
Constant Lestienne was the defending champion but retired in the first round against Simone Bolelli.
Sergiy Stakhovsky was the defending champion but lost in the quarterfinals to Constant Lestienne.
Peter Gojowczyk was the defending champion, but lost to Kei Nishikori in the second round.
Jo-Wilfried Tsonga was the defending champion, but lost in the second round to Gaël Monfils.
Vasek Pospisil was the defending champion but chose not to defend his title.
Karen Khachanov was the defending champion, but withdrew before the tournament began.
Constant Lestienne was the defending champion but lost in the semifinals to Viktor Durasovic.
Gilles Simon was the defending champion, but lost in the second round to Aljaž Bedene.
Filippo Baldi was the defending champion but lost in the third round to Lukáš Lacko.
Ričardas Berankis was the defending champion but chose not to defend his title.
Grégoire Barrère was the defending champion but chose not to defend his title.
Alexander Bublik was the defending champion but chose not to defend his title.
Lorenzo Sonego was the defending champion, but chose not to participate. Alex de Minaur defeated Alexander Bublik in the final, 2–0, after Bublik retired with an ankle injury.
Diego Schwartzman defeated Francisco Cerúndolo in the final, 6–1, 6–2 to win the men's singles tennis title at the 2021 Argentina Open.
Benjamin Bonzi was the defending champion but chose not to defend his title.
Oscar Otte was the defending champion but chose not to defend his title.