| Women's singles | |
|---|---|
| 2022 Lexington Challenger | |
| Champion |  Katie Swan |
| Runner-up | Jodie Burrage |
| Final score | 6–0, 3–6, 6–3 |
Jennifer Brady was the defending champion [1] but chose not to participate.
Katie Swan won the title, defeating Jodie Burrage in the final, 6–0, 3–6, 6–3.
Moyuka Uchijima (second round) Jodie Burrage (final)
Tessah Andrianjafitrimo (first round)
Priscilla Hon (first round) Seone Mendez (first round)
Lina Glushko (first round, retired) Lizette Cabrera (first round) Katie Swan (champion)| Semifinals | Final | ||||||||||||
| 8 | Katie Swan | 6 | 77 | ||||||||||
 Marcela Zacarías | 2 | 62 | |||||||||||
| 8 | Katie Swan | 6 | 3 | 6 | |||||||||
| 2 | Jodie Burrage | 0 | 6 | 3 | |||||||||
| Q |  Peyton Stearns | 6 | 4 | 3 | |||||||||
| 2 | Jodie Burrage | 1 | 6 | 6 | |||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | M Uchijima | 6 | 6 | ||||||||||||||||||||||||
 I Shymanovich | 3 | 1 | 1 | M Uchijima | 7 | 65 | 3 | ||||||||||||||||||||
| WC | M Sieg | 3 | 6 | 3r | Q | T Ng | 5 | 77 | 6 | ||||||||||||||||||
| Q | T Ng | 6 | 1 | 4 | Q | T Ng | 2 | 1 | |||||||||||||||||||
| K Scott | 6 | 6 | 8 | K Swan | 6 | 6 | |||||||||||||||||||||
| WC | S Crawford | 3 | 4 | K Scott | 3 | 7 | 66 | ||||||||||||||||||||
| C Van Nguyen | 4 | 1 | 8 | K Swan | 6 | 5 | 78 | ||||||||||||||||||||
| 8 | K Swan | 6 | 6 | 8 | K Swan | 6 | 77 | ||||||||||||||||||||
| 3 | T Andrianjafitrimo | 1 | 7 | 2 | M Zacarías | 2 | 62 | ||||||||||||||||||||
| M Timofeeva | 6 | 5 | 6 | M Timofeeva | 4 | 0r | |||||||||||||||||||||
| WC | Q Lopez | 3 | 3 | Q | V Miroshnichenko | 6 | 2 | ||||||||||||||||||||
| Q | V Miroshnichenko | 6 | 6 | Q | V Miroshnichenko | 2 | 4 | ||||||||||||||||||||
| Q | J Aney | 6 | 3 | 2 | M Zacarías | 6 | 6 | ||||||||||||||||||||
| Q |  J Tilbürger | 1 | 6 | 6 | Q | J Tilbürger | 1 | 64 | |||||||||||||||||||
| M Zacarías | 7 | 4 | M Zacarías | 6 | 77 | ||||||||||||||||||||||
| 6 | L Glushko | 5 | 0r | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 5 | S Mendez | 2 | 62 | ||||||||||||||||||||||||
 K Thandi | 6 | 77 | K Thandi | 7 | 6 | ||||||||||||||||||||||
| Q | E Oosterhout | 6 | 4 | 4 | WC |  A Sutjiadi | 5 | 0 | |||||||||||||||||||
| WC | A Sutjiadi | 4 | 6 | 6 | K Thandi | 3 | 1 | ||||||||||||||||||||
| Q | D Hewitt | 5 | 2 | Q | P Stearns | 6 | 6 | ||||||||||||||||||||
| Q | A Reami | 7 | 6 | Q | A Reami | 77 | 3 | 4 | |||||||||||||||||||
| Q | P Stearns | 77 | 6 | Q | P Stearns | 61 | 6 | 6 | |||||||||||||||||||
| 4 | P Hon | 62 | 4 | Q | P Stearns | 6 | 4 | 3 | |||||||||||||||||||
| 7 | L Cabrera | 3 | 0 | 2 | J Burrage | 1 | 6 | 6 | |||||||||||||||||||
| A Glatch | 6 | 6 | A Glatch | 77 | 5 | 0 | |||||||||||||||||||||
| H Chang | 6 | 4 | H Chang | 60 | 7 | 6 | |||||||||||||||||||||
| D Lao | 3 | 1r | H Chang | 3 | 1 | ||||||||||||||||||||||
| E Kalieva | 2 | 6 | 6 | 2 | J Burrage | 6 | 6 | ||||||||||||||||||||
| E Silva | 6 | 2 | 2 | E Kalieva | 2 | 68 | |||||||||||||||||||||
 K Volodko | 77 | 0 | 1 | 2 | J Burrage | 6 | 710 | ||||||||||||||||||||
| 2 | J Burrage | 65 | 6 | 6 | |||||||||||||||||||||||
Daria Kasatkina was the defending champion, but chose not to participate this year.
Paula Badosa was the defending champion, but was no longer eligible to participate.
Miriam Kolodziejová and Markéta Vondroušová were the defending champions, but Kolodziejová was ineligible to participate this year. Vondroušová played alongside Anastasia Dețiuc, but lost in the first round to Claire Liu and Charlotte Robillard-Millette.
Dalma Gálfi and Fanny Stollár were the defending champions, but chose not to participate this year.
Vera Lapko was the defending champion, but was no longer eligible to participate. Lapko competed in the women's singles qualifying but lost in the second round to Ons Jabeur.
Anna Kalinskaya and Tereza Mihalíková were the defending champions, but both players were ineligible to participate.
Jennifer Brady was the defending champion, but she chose to compete in Sacramento instead.
Donna Vekić was the defending champion, but lost in the semifinals to Johanna Konta in a rematch of the previous year's final.
Petra Kvitová was the defending champion, and successfully defended her title, defeating Magdaléna Rybáriková in the final, 4–6, 6–1, 6–2.
Elina Svitolina was the defending champion, but lost to Sloane Stephens in the semifinals.
Belinda Bencic was the champion the last time the event was held in 2017, but chose to compete in St. Petersburg instead.
Garbiñe Muguruza was the defending champion and successfully defended her title, after Victoria Azarenka retired in the final with a leg injury with the score at 6–1, 3–1.
Giuliana Olmos and Laura Pigossi were the defending champions, but both players chose not to participate.
Caroline Wozniacki was the defending champion, but lost to Naomi Osaka in the semifinals.
This was a new tournament in 2021.
Ashleigh Barty defeated Karolína Plíšková in the final, 6–3, 6–7(4–7), 6–3 to win the ladies' singles tennis title at the 2021 Wimbledon Championships. She became the first Australian to win the title since Evonne Goolagong Cawley in 1980, the first top seed to win the title since Serena Williams in 2016 and the first to do so at any major since Simona Halep at the 2018 French Open. Barty's victory made her the fourth player, following Ann Jones, Martina Hingis and Amélie Mauresmo, to win the women's singles title after previously winning the girls' singles title. She retained the WTA No. 1 singles ranking by reaching the semifinals, with Aryna Sabalenka having also been in contention for the top ranking.
Simona Halep was the defending champion, but chose not to participate.
Zoë Kruger was the defending champion but lost in the first round to Tímea Babos.
Daniela Seguel was the defending champion but lost in the quarterfinals to Deborah Chiesa.
Monica Niculescu was the defending champion but chose not to participate.