Filip Peliwo was the defending champion, but was no longer eligible to compete in junior tennis, and thus could not defend his title.
Noah Rubin was the defending champion, but chose not to participate this year.
Fernando Verdasco was the defending champion, but lost to Sam Querrey in the semifinals.
Jack Sock won his first ATP singles title, defeating Querrey in the final, 7–6(11–9), 7–6(7–2).
Go Soeda was the defending champion, but lost in the quarterfinals.
Rohan Bopanna and Daniel Nestor were the defending champions, but chose not to compete together. Bopanna played alongside Florin Mergea, but lost in the first round to Nestor and Radek Štěpánek. Nestor and Štěpánek lost in the quarterfinals to Łukasz Kubot and Marcin Matkowski.
Simone Bolelli and Andreas Seppi won the title, defeating Feliciano López and Marc López in the final, 6–2, 3–6, [14–12].
Tomáš Berdych was the defending champion and successfully defended his title, defeating Richard Gasquet in the final, 7−6(7−5), 6−7(2−7), 6−3.
Sam Querrey defeated Rafael Nadal in the final, 6–3, 7–6(7–3) to win the men's singles tennis title at the 2017 Mexican Open.
Nick Kyrgios was the defending champion, but withdrew before the tournament began.
Defending champion Roger Federer defeated Marin Čilić in the final, 6–2, 6–7(5–7), 6–3, 3–6, 6–1 to win the men's singles tennis title at the 2018 Australian Open. It was his record-equalling sixth Australian Open title, and his record-extending 20th and last major title overall. With the win, Federer became the oldest man to win a major singles title since Ken Rosewall in 1972. This was the tenth time that Federer defended a major title, the last time being at the 2008 US Open. Čilić became the first Croatian to reach an Australian Open singles final.
Steve Johnson was the defending champion and successfully defended his title, defeating Tennys Sandgren in the final, 7–6(7–2), 2–6, 6–4.
John Isner was the defending champion and successfully defended his title, defeating Ryan Harrison in a rematch of the 2017 final, 5–7, 6–3, 6–4.
Teymuraz Gabashvili and Dennis Novikov were the defending champions but only Novikov chose to defend his title, partnering Christian Harrison. Novikov successfully defended his title.
Nicolás Barrientos and Sergio Galdós were the defending champions but chose not to defend their title.
Luke Saville and John-Patrick Smith were the defending champions but chose not to defend their title.
Darian King and Peter Polansky were the defending champions but chose not to defend their title.
Adrian Mannarino defeated Laslo Đere in the final, 7–6(7–1), 6–4 to win the singles tennis title at the 2022 Winston-Salem Open. Mannarino saved four match points en route to the title, in his first-round match against Christopher O'Connell.
Robert Galloway and Roberto Maytín were the defending champions but chose not to defend their title.
Darian King and Peter Polansky were the defending champions but chose not to defend their title.
Lucas Miedler and Sebastian Ofner were the defending champions but chose not to defend their title.
Nathaniel Lammons and Jackson Withrow were the defending champions but chose not to defend their title.
Chung Yun-seong 
Michail Pervolarakis 
Malek Jaziri 
Kaichi Uchida 
