| Singles | |
|---|---|
| 2022 San Marino Open | |
| Champion |  Pavel Kotov |
| Runner-up |  Matteo Arnaldi |
| Score | 7–6(7–5), 6–4 |
Holger Rune was the defending champion [1] but chose not to defend his title.
Pavel Kotov won the title after defeating Matteo Arnaldi 7–6(7–5), 6–4 in the final.
Carlos Taberner (second round) Pavel Kotov (champion) Giulio Zeppieri (first round) Flavio Cobolli (first round) Marco Cecchinato (semifinals)
Alexandre Müller (first round)
Nino Serdarušić (first round) Matteo Arnaldi (final)| Semifinals | Final | ||||||||||||
| Alt |  Filip Cristian Jianu | 1 | 5 | ||||||||||
| 8 | Matteo Arnaldi | 6 | 7 | ||||||||||
| 8 | Matteo Arnaldi | 65 | 4 | ||||||||||
| 2 | Pavel Kotov | 77 | 6 | ||||||||||
| 5 | Marco Cecchinato | 6 | 5 | 1 | |||||||||
| 2 | Pavel Kotov | 3 | 7 | 6 | |||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | C Taberner | 6 | 2 | 6 | |||||||||||||||||||||||
| O Roca Batalla | 4 | 6 | 2 | 1 | C Taberner | 4 | 3 | ||||||||||||||||||||
| Alt | FC Jianu | 77 | 6 | Alt | FC Jianu | 6 | 6 | ||||||||||||||||||||
| WC |  E Gulbis | 64 | 0 | Alt | FC Jianu | 6 | 6 | ||||||||||||||||||||
 R Haase | 77 | 6 | N Sánchez Izquierdo | 2 | 4 | ||||||||||||||||||||||
 O Virtanen | 63 | 3 | R Haase | 6 | 1 | 3 | |||||||||||||||||||||
| N Sánchez Izquierdo | 3 | 6 | 6 | N Sánchez Izquierdo | 2 | 6 | 6 | ||||||||||||||||||||
| 6 | A Müller | 6 | 3 | 0 | Alt | FC Jianu | 1 | 5 | |||||||||||||||||||
| 4/WC | F Cobolli | 65 | 4 | 8 | M Arnaldi | 6 | 7 | ||||||||||||||||||||
 F Marozsán | 77 | 6 | F Marozsán | 6 | 6 | ||||||||||||||||||||||
| J Sels | 2 | 3 | M Gigante | 2 | 2 | ||||||||||||||||||||||
| M Gigante | 6 | 6 | F Marozsán | 4 | 2 | ||||||||||||||||||||||
| Alt | I Gakhov | 2 | 64 | 8 | M Arnaldi | 6 | 6 | ||||||||||||||||||||
| Q |  L Neumayer | 6 | 77 | Q | L Neumayer | 3 | 4 | ||||||||||||||||||||
| F Gaio | 2 | 0 | 8 | M Arnaldi | 6 | 6 | |||||||||||||||||||||
| 8 | M Arnaldi | 6 | 6 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 5 | M Cecchinato | 6 | 6 | ||||||||||||||||||||||||
| WC | M Bellucci | 2 | 1 | 5 | M Cecchinato | 63 | 78 | 6 | |||||||||||||||||||
 N Fatić | 3 | 2 | Q | F Forti | 77 | 66 | 2 | ||||||||||||||||||||
| Q | F Forti | 6 | 6 | 5 | M Cecchinato | 77 | 6 | ||||||||||||||||||||
| J de Jong | 6 | 6 | Q |  V Vacherot | 63 | 1 | |||||||||||||||||||||
 M Trungelliti | 3 | 4 | J de Jong | 2 | 3 | ||||||||||||||||||||||
| Q | V Vacherot | 2 | 77 | 6 | Q | V Vacherot | 6 | 6 | |||||||||||||||||||
| 3 | G Zeppieri | 6 | 62 | 1 | 5 | M Cecchinato | 6 | 5 | 1 | ||||||||||||||||||
| 7 | N Serdarušić | 60 | 6 | 3 | 2 | P Kotov | 3 | 7 | 6 | ||||||||||||||||||
| L Giustino | 77 | 4 | 6 | L Giustino | 2 | 5 | |||||||||||||||||||||
 T Skatov | 3 | 1 | Q | A Weis | 6 | 7 | |||||||||||||||||||||
| Q | Alexander Weis | 6 | 6 | Q | A Weis | 5 | 0 | ||||||||||||||||||||
| Alt | M Janvier | 6 | 3 | 7 | 2 | P Kotov | 7 | 6 | |||||||||||||||||||
| Q |  O Prihodko | 1 | 6 | 5 | Alt | M Janvier | 4 | 3 | |||||||||||||||||||
| Q |  V Durasovic | 1 | 1 | 2 | P Kotov | 6 | 6 | ||||||||||||||||||||
| 2 | P Kotov | 6 | 6 | ||||||||||||||||||||||||
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