| Singles | |
|---|---|
| 2022 Sparkassen ATP Challenger | |
| Champion |  Borna Gojo |
| Runner-up |  Lukáš Klein |
| Score | 7–6(7–4), 6–3 |
Oscar Otte was the defending champion [1] but chose not to defend his title.
Borna Gojo won the title after defeating Lukáš Klein 7–6(7–4), 6–3 in the final.
Tomáš Macháč (quarterfinals)
Nicolás Jarry (first round)
Luca Nardi (quarterfinals)
Yannick Hanfmann (second round) Giulio Zeppieri (quarterfinals) Flavio Cobolli (semifinals) Lukáš Klein (final)
Fábián Marozsán (first round)| Semifinals | Final | ||||||||||||
| Andrea Vavassori | 65 | 4 | |||||||||||
| 7 | Lukáš Klein | 77 | 6 | ||||||||||
| 7 | Lukáš Klein | 64 | 3 | ||||||||||
| Borna Gojo | 77 | 6 | |||||||||||
| Borna Gojo | 6 | 6 | |||||||||||
| 6 | Flavio Cobolli | 1 | 1 | ||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | T Macháč | 6 | 6 | ||||||||||||||||||||||||
| Q | A Paulson | 4 | 1 | 1 | T Macháč | 6 | 6 | ||||||||||||||||||||
 A Escoffier | 77 | 6 | A Escoffier | 3 | 1 | ||||||||||||||||||||||
| Alt | M Bellucci | 63 | 4 | 1 | T Macháč | 6 | 3 | 4 | |||||||||||||||||||
| Q |  Sandro Kopp | 67 | 6 | 7 | A Vavassori | 1 | 6 | 6 | |||||||||||||||||||
| Q | Térence Atmane | 79 | 3 | 5 | Q | S Kopp | 3 | 4 | |||||||||||||||||||
| A Vavassori | 3 | 6 | 6 | A Vavassori | 6 | 6 | |||||||||||||||||||||
| 8 | F Marozsán | 6 | 1 | 3 | A Vavassori | 65 | 4 | ||||||||||||||||||||
| 3/WC | L Nardi | 77 | 6 | 7 | L Klein | 77 | 6 | ||||||||||||||||||||
| Q |  A Kachmazov | 64 | 4 | 3/WC | L Nardi | 6 | 6 | ||||||||||||||||||||
| P Gojowczyk | 2 | 1 | Q | E Karlovskiy | 0 | 4 | |||||||||||||||||||||
| Q | E Karlovskiy | 6 | 6 | 3/WC | L Nardi | 1 | 6 | 1 | |||||||||||||||||||
| A Arnaboldi | 2 | 3 | 7 | L Klein | 6 | 3 | 6 | ||||||||||||||||||||
 N Fatić | 6 | 6 | N Fatić | 3 | 2r | ||||||||||||||||||||||
| Alt | M Bašić | 3 | 4 | 7 | L Klein | 6 | 2 | ||||||||||||||||||||
| 7 | L Klein | 6 | 6 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 5 | G Zeppieri | 6 | 6 | ||||||||||||||||||||||||
| Q | P Nouza | 3 | 4 | 5 | G Zeppieri | 6 | 6 | ||||||||||||||||||||
| WC | S Travaglia | 2 | 6 | 6 | WC | S Travaglia | 3 | 2 | |||||||||||||||||||
| F Maestrelli | 6 | 3 | 4 | 5 | G Zeppieri | 5 | 2 | ||||||||||||||||||||
| M Gigante | 2 | 4 | B Gojo | 7 | 6 | ||||||||||||||||||||||
| B Gojo | 6 | 6 | B Gojo | 77 | 6 | ||||||||||||||||||||||
| A Seppi | 7 | 3 | 4 | 4 | Y Hanfmann | 63 | 2 | ||||||||||||||||||||
| 4 | Y Hanfmann | 5 | 6 | 6 | B Gojo | 6 | 6 | ||||||||||||||||||||
| 6 | F Cobolli | 77 | 6 | 6 | F Cobolli | 1 | 1 | ||||||||||||||||||||
| Alt | L Giustino | 64 | 4 | 6 | F Cobolli | 7 | 6 | ||||||||||||||||||||
| WC | F Arnaboldi | 4 | 6 | 1 |  A Ritschard | 5 | 1 | ||||||||||||||||||||
| A Ritschard | 6 | 2 | 6 | 6 | F Cobolli | 77 | 4 | 6 | |||||||||||||||||||
 M Trungelliti | 4 | 6 | 6 | L Rosol | 65 | 6 | 2 | ||||||||||||||||||||
| LL |  M Copil | 6 | 4 | 3 | M Trungelliti | 66 | 64 | ||||||||||||||||||||
| L Rosol | 4 | 6 | 77 | L Rosol | 78 | 77 | |||||||||||||||||||||
| 2 | N Jarry | 6 | 4 | 64 | |||||||||||||||||||||||
Roger Federer was the two-time defending champion and successfully defended his title, defeating Andreas Seppi in the final, 7–6(7–1), 6–4.
Jean-Julien Rojer and Horia Tecău were the defending champions, but lost in the semifinals to Philipp Petzschner and Alexander Peya.
Nicolas Mahut and Vasek Pospisil won the title, defeating Petzschner and Peya in the final, 7–6(7–2), 6–4.
Ivo Karlović was the defending champion, but lost in the quarterfinals to Peter Gojowczyk.
Arthur De Greef was the defending champion but chose not to defend his title.
Tomáš Berdych was the two-time defending champion, but withdrew before the competition began.
Luca Vanni was the defending champion but chose not to defend his title.
The men's singles of the 2018 Advantage Cars Prague Open tournament was played on clay in Prague, Czech Republic.
Vasek Pospisil was the defending champion but chose not to defend his title.
Maximilian Marterer was the defending champion but chose not to defend his title.
Yasutaka Uchiyama was the defending champion but chose not to defend his title.
Alex de Minaur was the defending champion but chose not to defend his title.
Yannick Hanfmann was the defending champion but lost in the second round to Casper Ruud.
Gilles Simon was the defending champion, but lost in the second round to Aljaž Bedene.
Antoine Hoang was the defending champion but chose not to defend his title.
Ričardas Berankis was the defending champion but chose not to defend his title.
Lorenzo Sonego was the defending champion, but chose not to participate. Alex de Minaur defeated Alexander Bublik in the final, 2–0, after Bublik retired with an ankle injury.
Pavel Kotov and Roman Safiullin were the defending champions but chose not to defend their title.
Diego Schwartzman defeated Francisco Cerúndolo in the final, 6–1, 6–2 to win the men's singles tennis title at the 2021 Argentina Open.
Artem Sitak and Igor Zelenay were the defending champions but only Zelenay chose to defend his title, partnering Roman Jebavý. Zelenay lost in the quarterfinals to Zdeněk Kolář and Lukáš Rosol.
Constant Lestienne was the defending champion but chose not to defend his title.