| Singles | |
|---|---|
| 2022 Uruguay Open | |
| Champion |  Genaro Alberto Olivieri |
| Runner-up | Tomás Martín Etcheverry |
| Score | 6–7(3–7), 7–6(7–5), 6–3 |
Hugo Dellien was the defending champion [1] but chose not to defend his title.
Genaro Alberto Olivieri won the title after defeating Tomás Martín Etcheverry 6–7(3–7), 7–6(7–5), 6–3 in the final.
Federico Coria (withdrew) Tomás Martín Etcheverry (final)
Daniel Altmaier (semifinals) Facundo Bagnis (quarterfinals)
Marco Cecchinato (first round) Camilo Ugo Carabelli (first round) Juan Manuel Cerúndolo (second round, retired) Franco Agamenone (semifinals)| Semifinals | Final | ||||||||||||
| Alt | Genaro Alberto Olivieri | 2 | 6 | 6 | |||||||||
| 8 | Franco Agamenone | 6 | 4 | 4 | |||||||||
| Alt | Genaro Alberto Olivieri | 63 | 77 | 6 | |||||||||
| 2 | Tomás Martín Etcheverry | 77 | 65 | 3 | |||||||||
| 3 | Daniel Altmaier | 77 | 3 | 66 | |||||||||
| 2 | Tomás Martín Etcheverry | 65 | 6 | 78 | |||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| Q |  E Ribeiro | 7 | 0 | 2 | |||||||||||||||||||||||
 G Elias | 5 | 6 | 6 | G Elias | 5 | 3 | |||||||||||||||||||||
| Q |  J Choinski | 5 | 5 | Alt | GA Olivieri | 7 | 6 | ||||||||||||||||||||
| Alt | GA Olivieri | 7 | 7 | Alt | GA Olivieri | 6 | 6 | ||||||||||||||||||||
| Q |  M Houkes | 7 | 6 | M Trungelliti | 1 | 4 | |||||||||||||||||||||
| WC |  F Roncadelli | 5 | 2 | Q | M Houkes | 66 | 2 | ||||||||||||||||||||
| M Trungelliti | 6 | 6 | M Trungelliti | 78 | 6 | ||||||||||||||||||||||
| 5 | M Cecchinato | 4 | 4 | Alt | GA Olivieri | 2 | 6 | 6 | |||||||||||||||||||
| 4 | F Bagnis | 77 | 6 | 8 | F Agamenone | 6 | 4 | 4 | |||||||||||||||||||
| Q |  F Zeballos | 65 | 3 | 4 | F Bagnis | 65 | 6 | 6 | |||||||||||||||||||
| LL | G Villanueva | 4 | 69 | Q | JP Paz | 77 | 1 | 0 | |||||||||||||||||||
| Q | JP Paz | 6 | 711 | 4 | F Bagnis | 6 | 1 | 2 | |||||||||||||||||||
| F Comesaña | 1 | 1 | 8 | F Agamenone | 3 | 6 | 6 | ||||||||||||||||||||
| Q |  M Echargui | 6 | 6 | Q | M Echargui | 5 | 3 | ||||||||||||||||||||
| A Collarini | 4 | 5 | 8 | F Agamenone | 7 | 6 | |||||||||||||||||||||
| 8 | F Agamenone | 6 | 7 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 6 | C Ugo Carabelli | 4 | 4 | ||||||||||||||||||||||||
| N Kicker | 6 | 6 | N Kicker | 4 | 6 | 6 | |||||||||||||||||||||
| M Pucinelli de Almeida | 77 | 6 | M Pucinelli de Almeida | 6 | 3 | 3 | |||||||||||||||||||||
| S Rodríguez Taverna | 65 | 3 | N Kicker | 4 | 6 | 3 | |||||||||||||||||||||
| F Meligeni Alves | 6 | 6 | 3 | D Altmaier | 6 | 1 | 6 | ||||||||||||||||||||
| PR |  S Nagal | 4 | 3 | F Meligeni Alves | 65 | 3 | |||||||||||||||||||||
| JB Torres | 2 | 2 | 3 | D Altmaier | 77 | 6 | |||||||||||||||||||||
| 3 | D Altmaier | 6 | 6 | 3 | D Altmaier | 77 | 3 | 66 | |||||||||||||||||||
| 7 | JM Cerúndolo | 7 | 6 | 2 | TM Etcheverry | 65 | 6 | 78 | |||||||||||||||||||
| WC | G Pella | 5 | 3 | 7 | JM Cerúndolo | 3 | 0r | ||||||||||||||||||||
| H Casanova | 3 | 1r | F Díaz Acosta | 6 | 3 | ||||||||||||||||||||||
| F Díaz Acosta | 6 | 4 | F Díaz Acosta | 5 | 4 | ||||||||||||||||||||||
| WC |  L Borg | 5 | 1 | 2 | TM Etcheverry | 7 | 6 | ||||||||||||||||||||
| M Navone | 7 | 6 | M Navone | 4 | 1 | ||||||||||||||||||||||
| Alt |  N Milojević | 3 | 2 | 2 | TM Etcheverry | 6 | 6 | ||||||||||||||||||||
| 2 | TM Etcheverry | 6 | 6 | ||||||||||||||||||||||||
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