| Men's singles | |
|---|---|
| 2023 San Luis Open Challenger | |
| Champion |  Tomás Barrios Vera |
| Runner-up |  Dominik Koepfer |
| Score | 7–6(8–6), 7–5 |
Antoine Bellier was the defending champion [1] but lost in the first round to Alexis Galarneau.
Tomás Barrios Vera won the title after defeating Dominik Koepfer 7–6(8–6), 7–5 in the final.
James Duckworth (first round)
Antoine Bellier (first round) Tomás Barrios Vera (champion)
Renzo Olivo (second round, retired) Facundo Mena (first round)
Rio Noguchi (first round) Juan Pablo Ficovich (first round)
Nick Hardt (first round)| Semifinals | Final | ||||||||||||
 Jan Choinski | 3 | 3 | |||||||||||
| Dominik Koepfer | 6 | 6 | |||||||||||
| Dominik Koepfer | 66 | 5 | |||||||||||
| 3 | Tomás Barrios Vera | 78 | 7 | ||||||||||
| 3 | Tomás Barrios Vera | 6 | 6 | ||||||||||
| Q |  Patrick Kypson | 4 | 3 | ||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | J Duckworth | 64 | 6 | 3 | |||||||||||||||||||||||
| TA Tirante | 77 | 4 | 6 | TA Tirante | 6 | 6 | |||||||||||||||||||||
 A Dougaz | 2 | 2 | F Comesaña | 2 | 3 | ||||||||||||||||||||||
| F Comesaña | 6 | 6 | TA Tirante | 4 | 4 | ||||||||||||||||||||||
 JL Reis da Silva | 6 | 3 | 6 | J Choinski | 6 | 6 | |||||||||||||||||||||
| A Walton | 1 | 6 | 4 | JL Reis da Silva | 5 | 5 | |||||||||||||||||||||
| J Choinski | 4 | 7 | 6 | J Choinski | 7 | 7 | |||||||||||||||||||||
| 5 | F Mena | 6 | 5 | 2 | J Choinski | 3 | 3 | ||||||||||||||||||||
| 4 | R Olivo | 7 | 6 | D Koepfer | 6 | 6 | |||||||||||||||||||||
| Q |  R Statham | 5 | 3 | 4 | R Olivo | 4 | 1r | ||||||||||||||||||||
 J Jung | 0 | 63 |  M Neuchrist | 6 | 4 | ||||||||||||||||||||||
| M Neuchrist | 6 | 77 | M Neuchrist | 6 | 1 | 4 | |||||||||||||||||||||
| RA Burruchaga | 1 | 3 | D Koepfer | 4 | 6 | 6 | |||||||||||||||||||||
| D Koepfer | 6 | 6 | D Koepfer | 6 | 6 | ||||||||||||||||||||||
| Q |  D Yevseyev | 7 | 77 | Q | D Yevseyev | 3 | 2 | ||||||||||||||||||||
| 8 | N Hardt | 5 | 61 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 7 | JP Ficovich | 64 | 3 | ||||||||||||||||||||||||
| Q |  G Mpetshi Perricard | 77 | 6 | Q | G Mpetshi Perricard | 77 | 6 | ||||||||||||||||||||
 N Mejía | 4 | 65 |  M Dellien | 64 | 3 | ||||||||||||||||||||||
| M Dellien | 6 | 77 | Q | G Mpetshi Perricard | 4 | 6 | 4 | ||||||||||||||||||||
| Elmar Ejupovic | 6 | 6 | 3 | T Barrios Vera | 6 | 4 | 6 | ||||||||||||||||||||
| WC | L Pouille | 3 | 3 | E Ejupovic | 6 | 0 | 64 | ||||||||||||||||||||
| Q | N Chappell | 65 | 1 | 3 | T Barrios Vera | 3 | 6 | 77 | |||||||||||||||||||
| 3 | T Barrios Vera | 77 | 6 | 3 | T Barrios Vera | 6 | 6 | ||||||||||||||||||||
| 6 | R Noguchi | 2 | 65 | Q | P Kypson | 4 | 3 | ||||||||||||||||||||
| WC |  R Pacheco Méndez | 6 | 77 | WC | R Pacheco Méndez | 3 | 3 | ||||||||||||||||||||
 AD Vallejo | 1 | 3 | Q | P Kypson | 6 | 6 | |||||||||||||||||||||
| Q | P Kypson | 6 | 6 | Q | P Kypson | 6 | 65 | 6 | |||||||||||||||||||
| Q |  B Lock | 6 | 3 | 5 | T Atmane | 2 | 77 | 2 | |||||||||||||||||||
| Térence Atmane | 2 | 6 | 7 | T Atmane | 7 | 4 | 6 | ||||||||||||||||||||
| LL |  A Galarneau | 6 | 6 | LL | A Galarneau | 5 | 6 | 4 | |||||||||||||||||||
| 2 | A Bellier | 2 | 4 | ||||||||||||||||||||||||
Noah Rubin was the defending champion, but chose not to participate this year.
Omar Jasika and Naoki Nakagawa are the defending champions, but they chose not to participate.
Félix Auger-Aliassime and Denis Shapovalov won the title, defeating Brandon Holt and Riley Smith in the final, 7–5, 7–6(7–3).
Marcelo Arévalo was the defending champion but lost in the second round to Marcelo Tomás Barrios Vera.
Damir Džumhur was the defending champion, but retired from his quarterfinal match against Jordan Thompson.
Reilly Opelka was the defending champion, but withdrew from the event.
Cristian Garín was the defending champion, but chose not to defend his title.
Pedro Sousa was the defending champion but chose not to defend his title.
Emil Ruusuvuori was the defending champion but chose not to defend his title.
Juan Pablo Varillas was the defending champion but lost in the quarterfinals to Marcelo Tomás Barrios Vera.
Julian Lenz and Gerald Melzer were the defending champions but chose not to defend their title.
Albert Ramos Viñolas defeated Alejandro Tabilo in the final, 4–6, 6–3, 6–4 to win the singles title at the 2022 Córdoba Open.
Francisco Cerúndolo was the defending champion but chose not to defend his title.
Federico Coria was the defending champion but chose not to defend his title.
This was the first edition of the tournament and was part of the 2022 Legión Sudamericana.
This was the first edition of the tournament and was part of the 2022 Legión Sudamericana.
Bernabé Zapata Miralles was the defending champion but chose not to defend his title.
This was the first edition of the tournament. The tournament originated as a quick replacement for the 2022 edition of the Quito Challenger, which was moved to Cali due to political unrest in Quito.
Tomás Barrios Vera was the defending champion but chose not to defend his title.
Oscar Otte was the defending champion but chose not to defend his title.
This was the first edition of the tournament.