| Men's singles | |
|---|---|
| 2023 San Luis Open Challenger | |
| Champion |  Tomás Barrios Vera |
| Runner-up |  Dominik Koepfer |
| Score | 7–6(8–6), 7–5 |
Antoine Bellier was the defending champion [1] but lost in the first round to Alexis Galarneau.
Tomás Barrios Vera won the title after defeating Dominik Koepfer 7–6(8–6), 7–5 in the final. [2]
James Duckworth (first round)
Antoine Bellier (first round) Tomás Barrios Vera (champion)
Renzo Olivo (second round, retired) Facundo Mena (first round)
Rio Noguchi (first round) Juan Pablo Ficovich (first round)
Nick Hardt (first round)| Semifinals | Final | ||||||||||||
 Jan Choinski | 3 | 3 | |||||||||||
| Dominik Koepfer | 6 | 6 | |||||||||||
| Dominik Koepfer | 66 | 5 | |||||||||||
| 3 | Tomás Barrios Vera | 78 | 7 | ||||||||||
| 3 | Tomás Barrios Vera | 6 | 6 | ||||||||||
| Q |  Patrick Kypson | 4 | 3 | ||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 1 | J Duckworth | 64 | 6 | 3 | |||||||||||||||||||||||
| TA Tirante | 77 | 4 | 6 | TA Tirante | 6 | 6 | |||||||||||||||||||||
 A Dougaz | 2 | 2 | F Comesaña | 2 | 3 | ||||||||||||||||||||||
| F Comesaña | 6 | 6 | TA Tirante | 4 | 4 | ||||||||||||||||||||||
 JL Reis da Silva | 6 | 3 | 6 | J Choinski | 6 | 6 | |||||||||||||||||||||
| A Walton | 1 | 6 | 4 | JL Reis da Silva | 5 | 5 | |||||||||||||||||||||
| J Choinski | 4 | 7 | 6 | J Choinski | 7 | 7 | |||||||||||||||||||||
| 5 | F Mena | 6 | 5 | 2 | J Choinski | 3 | 3 | ||||||||||||||||||||
| 4 | R Olivo | 7 | 6 | D Koepfer | 6 | 6 | |||||||||||||||||||||
| Q |  R Statham | 5 | 3 | 4 | R Olivo | 4 | 1r | ||||||||||||||||||||
 J Jung | 0 | 63 |  M Neuchrist | 6 | 4 | ||||||||||||||||||||||
| M Neuchrist | 6 | 77 | M Neuchrist | 6 | 1 | 4 | |||||||||||||||||||||
| RA Burruchaga | 1 | 3 | D Koepfer | 4 | 6 | 6 | |||||||||||||||||||||
| D Koepfer | 6 | 6 | D Koepfer | 6 | 6 | ||||||||||||||||||||||
| Q |  D Yevseyev | 7 | 77 | Q | D Yevseyev | 3 | 2 | ||||||||||||||||||||
| 8 | N Hardt | 5 | 61 | ||||||||||||||||||||||||
| First round | Second round | Quarterfinals | Semifinals | ||||||||||||||||||||||||
| 7 | JP Ficovich | 64 | 3 | ||||||||||||||||||||||||
| Q |  G Mpetshi Perricard | 77 | 6 | Q | G Mpetshi Perricard | 77 | 6 | ||||||||||||||||||||
 N Mejía | 4 | 65 |  M Dellien | 64 | 3 | ||||||||||||||||||||||
| M Dellien | 6 | 77 | Q | G Mpetshi Perricard | 4 | 6 | 4 | ||||||||||||||||||||
| Elmar Ejupovic | 6 | 6 | 3 | T Barrios Vera | 6 | 4 | 6 | ||||||||||||||||||||
| WC | L Pouille | 3 | 3 | E Ejupovic | 6 | 0 | 64 | ||||||||||||||||||||
| Q | N Chappell | 65 | 1 | 3 | T Barrios Vera | 3 | 6 | 77 | |||||||||||||||||||
| 3 | T Barrios Vera | 77 | 6 | 3 | T Barrios Vera | 6 | 6 | ||||||||||||||||||||
| 6 | R Noguchi | 2 | 65 | Q | P Kypson | 4 | 3 | ||||||||||||||||||||
| WC |  R Pacheco Méndez | 6 | 77 | WC | R Pacheco Méndez | 3 | 3 | ||||||||||||||||||||
 AD Vallejo | 1 | 3 | Q | P Kypson | 6 | 6 | |||||||||||||||||||||
| Q | P Kypson | 6 | 6 | Q | P Kypson | 6 | 65 | 6 | |||||||||||||||||||
| Q |  B Lock | 6 | 3 | 5 | T Atmane | 2 | 77 | 2 | |||||||||||||||||||
| T Atmane | 2 | 6 | 7 | T Atmane | 7 | 4 | 6 | ||||||||||||||||||||
| LL |  A Galarneau | 6 | 6 | LL | A Galarneau | 5 | 6 | 4 | |||||||||||||||||||
| 2 | A Bellier | 2 | 4 | ||||||||||||||||||||||||
Pedro Sousa was the defending champion but chose not to defend his title.
Sebastián Báez was the defending champion but lost in the final to Juan Pablo Varillas.
Juan Pablo Varillas was the defending champion but lost in the quarterfinals to Marcelo Tomás Barrios Vera.
Julian Lenz and Gerald Melzer were the defending champions but chose not to defend their title.
Francisco Cerúndolo was the defending champion but chose not to defend his title.
Jenson Brooksby was the defending champion but chose not to defend his title.
Federico Coria was the defending champion but chose not to defend his title.
This was the first edition of the tournament and was part of the 2022 Legión Sudamericana.
This was the first edition of the tournament and was part of the 2022 Legión Sudamericana.
Bernabé Zapata Miralles was the defending champion but chose not to defend his title.
This was the first edition of the tournament. The tournament originated as a quick replacement for the 2022 edition of the Quito Challenger, which was moved to Cali due to political unrest in Quito.
Tomás Barrios Vera was the defending champion but chose not to defend his title.
This was the first edition of the tournament.
Igor Marcondes was the defending champion but chose not to defend his title.
Jay Clarke was the defending champion but lost in the second round to Térence Atmane.
Arthur Rinderknech was the defending champion but chose not to defend his title.
Raúl Brancaccio was the defending champion but lost in the first round to Hernán Casanova.
Francesco Passaro was the defending champion but lost in the final to Hugo Gaston.
Luca Nardi was the defending champion but chose not to defend his title.
Tomás Barrios Vera was the defending champion but lost in the quarterfinals to Matías Soto.