Austin Krajicek and César Ramírez are the defending champions, but only Ramírez defended his title partnering Miguel Ángel Reyes-Varela, but lost in the semifinals to Nicolás Barrientos and Eduardo Struvay.
Andrés Molteni and Diego Schwartzman were the defending champions but only Molteni chose to defend his title, partnering Sergio Galdós. Molteni lost in the first round to Pedro Cachin and Nicolás Jarry.
Ken and Neal Skupski were the defending champions but chose not to defend their title.
Julian Ocleppo and Andrea Vavassori were the defending champions but chose to defend their title with different partners. Ocleppo partnered Andrea Pellegrino but lost in the first round to David Marrero and Roberto Maytín. Vavassori partnered Andrei Vasilevski but lost in the final to Tomislav Brkić and Ante Pavić.
Hugo Dellien and Guillermo Durán were the defending champions but only Dellien chose to defend his title, partnering Federico Zeballos. Dellien and Zeballos withdrew before their quarterfinal match.
Guido Andreozzi and Guillermo Durán were the defending champions but chose not to defend their title.
Andrey Golubev and Aleksandr Nedovyesov were the defending champions but chose not to defend their title.
Roberto Maytín and Fernando Romboli were the defending champions but only Romboli chose to defend his title, partnering Miguel Ángel Reyes-Varela.
Miguel Ángel Reyes-Varela and Fernando Romboli were the defending champions but chose not to defend their title.
Sander Arends and David Pel were the defending champions but chose not to defend their title.
André Göransson and Sem Verbeek were the defending champions but chose not to defend their title.
Íñigo Cervantes and Oriol Roca Batalla were the defending champions but chose not to defend his title.
Diego Hidalgo and Cristian Rodríguez were the defending champions but lost in the semifinals to Jesper de Jong and Bart Stevens.
Ruben Bemelmans and Tim Pütz were the defending champions but chose not to defend their title.
Szymon Walków and Jan Zieliński were the defending champions but chose not to defend their title.
Diego Hidalgo and Cristian Rodríguez were the defending champions but lost in the final to Pedro Boscardin Dias and João Lucas Reis da Silva.
Luciano Darderi and Fernando Romboli were the defending champions but chose to defend their title with different partners. Darderi partnered Andrea Collarini but lost in the first round to Marco Bortolotti and Sergio Martos Gornés. Romboli partnered Marcelo Zormann but lost in the first round to Boris Arias and Federico Zeballos.
Ruben Gonzales and Reese Stalder were the defending champions but chose not to defend their title.
Román Andrés Burruchaga and Facundo Díaz Acosta were the defending champions but chose not to defend their title.
Boris Arias and Federico Zeballos were the defending champions but lost in the first round to Marcelo Demoliner and Guillermo Durán.
Diego Hidalgo 
Miguel Ángel Reyes-Varela 
Sriram Balaji 
Fernando Romboli 
